HitPredict

Interactor 1: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Interactor 2: ISK7 (P58062)
Serine protease inhibitor Kazal-type 7 (Esophagus cancer-related gene 2 protein) (ECRG-2)
Gene: SPINK7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1019 Hs			1 85
+	Hs
		539804 IDE_HUMAN (1-1019): 0: 1084: 100.00		ISK14_HUMAN (43-85): 1.75e-16: 69.3: 60.47
+	Hs
		539774 IDE_HUMAN (1-1019): 0: 1084: 100.00		ISK2_HUMAN (28-85): 1.51e-11: 56.3: 34.48
+	Hs
		1127385 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		ISK14_HUMAN (43-85): 1.75e-16: 69.3: 60.47
+	Hs
		589710 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		ISK2_HUMAN (28-85): 1.51e-11: 56.3: 34.48
+	Hs
		264835 MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81		ISK2_HUMAN (28-85): 1.51e-11: 56.3: 34.48
+	Hs
		589707 MPPA_HUMAN (6-482): 9.37e-106: 341: 14.54		ISK2_HUMAN (28-85): 1.51e-11: 56.3: 34.48