HitPredict

Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	10514520
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 258
+	Hs
		147383 IL2RB_HUMAN (1-551): 0: 527: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		181785 IL2RB_HUMAN (1-551): 0: 527: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		411578 IL2RB_HUMAN (1-551): 0: 527: 100.00		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		540445 IL2RB_HUMAN (1-551): 0: 527: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		500974 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		560479 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		146586 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		146590 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Rn
		70070 GHR_RAT (27-485): 3.9e-60: 212: 15.27		B1WBX9_RAT (1-258): 3.95e-68: 212: 90.31
+	Hs
		147382 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		147385 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		181779 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		146592 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147386 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		500960 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		560475 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		500948 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129180 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Mm
		562609 GHR_MOUSE (22-522): 1.41e-61: 215: 14.69		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		433567 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21