Protein: VAMP8
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)

Gene: VAMP8
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q9BV40

Gene Ontology (top 5):
GO:0005484 - SNAP receptor activity
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

189809

STX7
Syntaxin-7

9

20

Small-scale

0.972

High

1100713

STX3
Syntaxin-3

6

20

Small-scale

0.940

High

226187

STX6
Syntaxin-6

5

20

Small-scale

0.927

High

1294822

STX12
Syntaxin-12

5

20

High-throughput

0.925

High

286721

STX11
Syntaxin-11

5

20

Small-scale

0.919

High

1414891

STX8
Syntaxin-8

4

20

Small-scale

0.909

High

933050

SNAA
Alpha-soluble NSF attachment protein

3

20

Small-scale

0.866

High

1326405

STX19
Syntaxin-19

3

20

High-throughput

0.861

High

1087264

STX4
Syntaxin-4

3

20

Small-scale

0.839

High

1154728

VAMP3
Vesicle-associated membrane protein 3

2

14

Small-scale

0.799

High

746221

STX2
Syntaxin-2

2

20

Small-scale

0.754

High

343460

SNP29
Synaptosomal-associated protein 29

6

20

Small-scale

0.734

High

1159628

STX1A
Syntaxin-1A

1

20

Small-scale

0.724

High

943122

STX17
Syntaxin-17

5

4

Small-scale

0.709

High

328729

VAMP5
Vesicle-associated membrane protein 5

1

14

High-throughput

0.691

High

1383304

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

20

Small-scale

0.691

High

1407039

SNAG
Gamma-soluble NSF attachment protein

1

20

High-throughput

0.691

High

1414886

STX18
Syntaxin-18

3

5

High-throughput

0.667

High

124095

SNP23
Synaptosomal-associated protein 23

3

20

Small-scale

0.656

High

180033

BET1
BET1 homolog

3

20

High-throughput

0.650

High

989378

VAMP2
Vesicle-associated membrane protein 2

1

15

Small-scale

0.647

High

1389791

DTBP1
Dysbindin

3

0

High-throughput

0.638

High

1158782

SYPL1
Synaptophysin-like protein 1

2

6

High-throughput

0.628

High

923475

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

2

2

High-throughput

0.611

High

1210976

CE170
Centrosomal protein of 170 kDa

2

4

High-throughput

0.611

High

1108392

MED21
Mediator of RNA polymerase II transcription subunit 21

3

1

High-throughput

0.604

High

374890

RASH
GTPase HRas

2

20

High-throughput

0.584

High

976525

RB11A
Ras-related protein Rab-11A

2

13

High-throughput

0.584

High

1414887

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

20

Small-scale

0.575

High

619914

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

302082

SEGN
Secretagogin

1

4

High-throughput

0.536

High

857166

NSF
Vesicle-fusing ATPase

1

8

High-throughput

0.536

High

1155382

RB11B
Ras-related protein Rab-11B

1

20

High-throughput

0.536

High

1309835

WDFY1
WD repeat and FYVE domain-containing protein 1

1

5

High-throughput

0.536

High

1414893

TMM98
Transmembrane protein 98

1

1

High-throughput

0.536

High

719177

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.518

High

952464

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.518

High

365775

KAD1
Adenylate kinase isoenzyme 1

1

0

High-throughput

0.513

High

861499

GNPI1
Glucosamine-6-phosphate deaminase 1

1

0

High-throughput

0.513

High

1407071

MDFI
MyoD family inhibitor

1

0

High-throughput

0.513

High

1414889

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.513

High

827477

MLH1
DNA mismatch repair protein Mlh1

1

2

Small-scale

0.508

High

1277553

UBE3B
Ubiquitin-protein ligase E3B

1

3

High-throughput

0.489

High

126774

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

178381

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

178834

SCAM1
Secretory carrier-associated membrane protein 1

1

10

High-throughput

0.479

High

218709

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

374170

RASN
GTPase NRas

1

20

High-throughput

0.479

High

375898

RASK
GTPase KRas

1

20

High-throughput

0.479

High

389503

FINC
Fibronectin

1

1

High-throughput

0.479

High

540652

LAMP1
Lysosome-associated membrane glycoprotein 1

1

17

High-throughput

0.479

High

560503

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

562368

LAMP2
Lysosome-associated membrane glycoprotein 2

1

17

High-throughput

0.479

High

564322

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

Small-scale

0.479

High

583104

VATB1
V-type proton ATPase subunit B, kidney isoform

1

3

High-throughput

0.479

High

598593

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.479

High

601426

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

630620

RAB3B
Ras-related protein Rab-3B

1

17

High-throughput

0.479

High

630953

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.479

High

631445

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

633936

ATP4A
Potassium-transporting ATPase alpha chain 1

1

14

Small-scale

0.479

High

715747

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

828246

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

Small-scale

0.479

High

901013

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901534

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

902039

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

953645

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955537

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

975212

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

978263

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1015729

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041254

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

1091838

TP4A2
Protein tyrosine phosphatase type IVA 2

1

3

Small-scale

0.479

High

1210105

SNP47
Synaptosomal-associated protein 47

1

4

Small-scale

0.479

High

1229064

RNF43
E3 ubiquitin-protein ligase RNF43

1

7

High-throughput

0.479

High

1233456

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1270969

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1334538

RN149
E3 ubiquitin-protein ligase RNF149

1

7

High-throughput

0.479

High

1362000

RFFL
E3 ubiquitin-protein ligase rififylin

1

2

Small-scale

0.479

High

1414883

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.479

High

1414884

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1414885

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1414888

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1414890

UBQL1
Ubiquilin-1

1

1

Small-scale

0.479

High

1414892

LAMP3
Lysosome-associated membrane glycoprotein 3

1

17

High-throughput

0.479

High

340669

STABP
STAM-binding protein

1

0

Small-scale

0.458

High

565466

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

971945

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

1252962

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

Small-scale

0.458

High

1333326

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1407805

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.458

High

1414881

TRIM6
Tripartite motif-containing protein 6

1

0

Small-scale

0.458

High

730

A0A087WXB0
Secretory carrier-associated membrane protein

1

10

High-throughput

0.445

High

800559

VATA
V-type proton ATPase catalytic subunit A

1

6

High-throughput

0.445

High

1049728

1433F
14-3-3 protein eta

1

2

High-throughput

0.445

High

1251183

ZNT10
Calcium/manganese antiporter SLC30A10

1

7

High-throughput

0.445

High

1340559

MFSD8
Major facilitator superfamily domain-containing protein 8

1

4

High-throughput

0.445

High

1414880

S12A9
Solute carrier family 12 member 9

1

7

High-throughput

0.445

High

1414882

PININ
Pinin

1

0

High-throughput

0.438

High

589576

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696387

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

769056

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1293131

TMM17
Transmembrane protein 17

1

5

High-throughput

0.437

High

1396573

C170L
Cep170-like protein

1

1

High-throughput

0.407

High


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Last updated: 11Aug2025