HitPredict

Interactor 1: GBRA1 (P14867)
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1)
Gene: GABRA1

Interactor 2: GBRG2 (P18507)
Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) (GABAAR subunit gamma-2)
Gene: GABRG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 36030824, 30602789
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Neur_chan_LBD~Neur_chan_LBD, Neur_chan_LBD~Neur_chan_memb, Neur_chan_memb~Neur_chan_memb
Common GO terms GO:0004890 - GABA-A receptor activity
GO:0005237 - inhibitory extracellular ligand-gated monoatomic ion channel activity
GO:0005886 - plasma membrane
GO:0007214 - gamma-aminobutyric acid signaling pathway
GO:0008503 - benzodiazepine receptor activity
and 16 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 456
Hs

1 475
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024