HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24981860, 38697112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 486
+	Mm
		1048263 TOP1_MOUSE (1-765): 0: 942: 96.48		MECP2_MOUSE (1-486): 5.36e-112: 341: 94.44
+	Hs
		542070 TOP1_HUMAN (1-765): 0: 952: 100.00		NIPBL_HUMAN (72-455): 1.96e-09: 62.4: 14.06
+	Hs
		904837 NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29		MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00
+	Hs
		1235637 NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29		NIPBL_HUMAN (72-455): 1.96e-09: 62.4: 14.06