Protein: MECP2
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Gene: MECP2
Organism: Mus musculus
Interactions: 97
UniProt ID: Q9Z2D6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000792 - heterochromatin
GO:0001662 - behavioral fear response
GO:0001666 - response to hypoxia
GO:0001964 - startle response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

148744

HDAC1
Histone deacetylase 1

2

19

Small-scale

0.754

High

313132

HDAC3
Histone deacetylase 3

1

19

Small-scale

0.691

High

1223254

ATRX
Transcriptional regulator ATRX

3

20

Small-scale

0.670

High

1221146

SIN3A
Paired amphipathic helix protein Sin3a

3

6

Small-scale

0.656

High

1222113

NCOR1
Nuclear receptor corepressor 1

1

13

Small-scale

0.646

High

1189484

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

3

20

Small-scale

0.633

High

1243917

SMRC2
SWI/SNF complex subunit SMARCC2

1

13

Small-scale

0.618

High

1491920

MBD3
Methyl-CpG-binding domain protein 3

1

11

Small-scale

0.618

High

1491921

MBD2
Methyl-CpG-binding domain protein 2

1

11

Small-scale

0.618

High

1423811

SMC1A
Structural maintenance of chromosomes protein 1A

2

10

Small-scale

0.611

High

1423826

SMC3
Structural maintenance of chromosomes protein 3

2

6

Small-scale

0.611

High

1240217

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.575

High

266622

DHX9
ATP-dependent RNA helicase A

2

14

Small-scale

0.571

High

1231602

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

2

20

Small-scale

0.571

High

1222991

EWS
RNA-binding protein EWS

1

7

High-throughput

0.541

High

991161

HMGB1
High mobility group protein B1

1

20

Small-scale

0.536

High

1296653

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

17

Small-scale

0.536

High

1423963

HNRPM
Heterogeneous nuclear ribonucleoprotein M

2

5

Small-scale

0.521

High

1222118

FOXG1
Forkhead box protein G1

1

9

Small-scale

0.515

High

1424080

PHF14
PHD finger protein 14

1

9

Small-scale

0.515

High

1424362

TCF20
Transcription factor 20

1

20

Small-scale

0.515

High

74307

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

205589

O35846
Brm protein

1

14

Small-scale

0.500

High

205540

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

15

Small-scale

0.479

High

237175

SAP18
Histone deacetylase complex subunit SAP18

1

2

Small-scale

0.479

High

267169

SP3
Transcription factor Sp3

1

9

Small-scale

0.479

High

312435

DNM3A
DNA

1

7

Small-scale

0.479

High

313420

SP1
Transcription factor Sp1

1

8

Small-scale

0.479

High

704236

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

5

Small-scale

0.479

High

840638

PURA
Transcriptional activator protein Pur-alpha

1

1

Small-scale

0.479

High

943024

FUS
RNA-binding protein FUS

1

12

Small-scale

0.479

High

974893

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

Small-scale

0.479

High

991484

SUMO1
Small ubiquitin-related modifier 1

1

4

Small-scale

0.479

High

995392

CSK2B
Casein kinase II subunit beta

1

3

Small-scale

0.479

High

1000193

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

15

Small-scale

0.479

High

1000366

TP53B
TP53-binding protein 1

1

16

Small-scale

0.479

High

1014281

CBX1
Chromobox protein homolog 1

1

19

Small-scale

0.479

High

1028526

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

13

Small-scale

0.479

High

1029591

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.479

High

1041430

CDK7
Cyclin-dependent kinase 7

1

3

Small-scale

0.479

High

1053391

IF2P
Eukaryotic translation initiation factor 5B

1

2

Small-scale

0.479

High

1222086

RBBP4
Histone-binding protein RBBP4

1

16

Small-scale

0.479

High

1222199

LAP2B
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

1

1

Small-scale

0.479

High

1222774

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

4

Small-scale

0.479

High

1223245

CBX5
Chromobox protein homolog 5

1

18

Small-scale

0.479

High

1223429

NPM
Nucleophosmin

1

3

Small-scale

0.479

High

1239843

ANM6
Protein arginine N-methyltransferase 6

1

4

Small-scale

0.479

High

1243478

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

4

Small-scale

0.479

High

1244512

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

5

Small-scale

0.479

High

1283009

SAFB2
Scaffold attachment factor B2

1

11

Small-scale

0.479

High

1297370

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

10

Small-scale

0.479

High

1298152

Q8C839
Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein

1

1

Small-scale

0.479

High

1317331

MATR3
Matrin-3

1

8

Small-scale

0.479

High

1317334

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

13

Small-scale

0.479

High

1354093

P66B
Transcriptional repressor p66-beta

1

6

Small-scale

0.479

High

1362865

TADBP
TAR DNA-binding protein 43

1

12

Small-scale

0.479

High

1363040

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

3

Small-scale

0.479

High

1408729

PSIP1
PC4 and SFRS1-interacting protein

1

15

Small-scale

0.479

High

1408739

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

5

Small-scale

0.479

High

1408802

PRP19
Pre-mRNA-processing factor 19

1

18

Small-scale

0.479

High

1424246

Q9DCC5
Cbx3 protein

1

18

Small-scale

0.479

High

1491910

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

3

Small-scale

0.479

High

1491912

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

11

Small-scale

0.479

High

1491922

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

15

Small-scale

0.479

High

973659

RS11
Small ribosomal subunit protein uS17

1

0

Small-scale

0.458

High

148374

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

Small-scale

0.445

High

205358

HAP1
Huntingtin-associated protein 1

1

6

Small-scale

0.445

High

236740

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

16

Small-scale

0.445

High

312624

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

16

Small-scale

0.445

High

470788

NFL
Neurofilament light polypeptide

1

16

Small-scale

0.445

High

480994

NUCL
Nucleolin

1

7

Small-scale

0.445

High

833809

KDM5C
Lysine-specific demethylase 5C

1

9

Small-scale

0.445

High

902769

RORA
Nuclear receptor ROR-alpha

1

11

Small-scale

0.445

High

1000171

TBX5
T-box transcription factor TBX5

1

3

Small-scale

0.445

High

1022016

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

18

Small-scale

0.445

High

1048263

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.445

High

1197473

DDX17
Probable ATP-dependent RNA helicase DDX17

1

10

Small-scale

0.445

High

1223195

DDX5
Probable ATP-dependent RNA helicase DDX5

1

10

Small-scale

0.445

High

1223846

DDX3X
ATP-dependent RNA helicase DDX3X

1

9

Small-scale

0.445

High

1234205

JADE3
Protein Jade-3

1

5

Small-scale

0.445

High

1244307

MED16
Mediator of RNA polymerase II transcription subunit 16

1

1

Small-scale

0.445

High

1295904

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

14

Small-scale

0.445

High

1297337

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

Small-scale

0.445

High

1298165

MYEF2
Myelin expression factor 2

1

5

Small-scale

0.445

High

1354043

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

13

Small-scale

0.445

High

1354146

SFPQ
Splicing factor, proline- and glutamine-rich

1

9

Small-scale

0.445

High

1408998

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

Small-scale

0.445

High

1440853

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

10

Small-scale

0.445

High

1491923

TOP3B
DNA topoisomerase 3-beta-1

1

1

Small-scale

0.445

High

399249

CFAD
Complement factor D

1

3

High-throughput

0.437

High

548979

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

5

Small-scale

0.437

High

1296493

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

7

High-throughput

0.437

High

1317937

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.437

High

1363065

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

5

Small-scale

0.437

High

1297377

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

Small-scale

0.426

High

1354125

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.426

High

1440814

TMOD3
Tropomodulin-3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025