Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)

Gene: TOP1
Organism: Mus musculus
Interactions: 24
UniProt ID: Q04750

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000932 - P-body
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001650 - fibrillar center
GO:0001651 - dense fibrillar component

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1048251

HDAC4
Histone deacetylase 4

1

4

High-throughput

0.536

High

58990

CUL4B
Cullin-4B

1

2

Small-scale

0.479

High

644296

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

1

Small-scale

0.479

High

921240

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

Small-scale

0.479

High

965994

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

High-throughput

0.479

High

1048252

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

1048253

DCAF1
DDB1- and CUL4-associated factor 1

1

2

Small-scale

0.479

High

1048256

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1048258

ELF5
ETS-related transcription factor Elf-5

1

1

High-throughput

0.479

High

1048259

EED
Polycomb protein EED

1

5

High-throughput

0.479

High

1048248

Q5SXC4
Vascular endothelial zinc finger 1

1

0

Small-scale

0.458

High

1048250

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

0

High-throughput

0.458

High

1048254

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.458

High

1048260

FOXP3
Forkhead box protein P3

1

0

High-throughput

0.458

High

1048249

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.445

High

1048255

COX15
Heme A synthase COX15

1

1

High-throughput

0.445

High

1048261

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.445

High

1048263

MECP2
Methyl-CpG-binding protein 2

1

3

Small-scale

0.445

High

915550

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High

1000120

TBX5
T-box transcription factor TBX5

1

0

Small-scale

0.426

High

771698

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.407

High

398362

CFAD
Complement factor D

1

0

High-throughput

0.249

Low

1048257

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low

1048262

PRAF1
Prenylated Rab acceptor protein 1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025