Interactor 1: BRAF (P15056)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Gene: BRAF
Interactor 2: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32707033, 28514442, 27034005, 31980649, 33961781, 36585710, 17979178, unassigned2173, 25600339, 24746704 |
| Identification Methods | affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~Pkinase, PK_Tyr_Ser-Thr~Pkinase |
| Common GO terms | GO:0000165 - MAPK cascade GO:0004674 - protein serine/threonine kinase activity GO:0004708 - MAP kinase kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus and 10 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
