Protein: NR1H2
Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)

Gene: NR1H2
Organism: Homo sapiens
Interactions: 72
UniProt ID: P55055

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873150

RXRG
Retinoic acid receptor RXR-gamma

9

20

High-throughput

0.969

High

625788

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.922

High

704511

RXRB
Retinoic acid receptor RXR-beta

4

20

Small-scale

0.873

High

933942

NR0B2
Nuclear receptor subfamily 0 group B member 2

2

18

Small-scale

0.768

High

933953

MDFI
MyoD family inhibitor

4

2

High-throughput

0.698

High

789453

PPARG
Peroxisome proliferator-activated receptor gamma

1

19

Small-scale

0.692

High

933936

PPARD
Peroxisome proliferator-activated receptor delta

1

20

Small-scale

0.692

High

933937

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.692

High

278285

NCOR1
Nuclear receptor corepressor 1

3

20

Small-scale

0.661

High

337999

ABCA1
Phospholipid-transporting ATPase ABCA1

3

3

Small-scale

0.633

High

520539

RARA
Retinoic acid receptor alpha

1

17

High-throughput

0.621

High

543483

VDR
Vitamin D3 receptor

1

20

High-throughput

0.621

High

933944

NCOA1
Nuclear receptor coactivator 1

1

20

High-throughput

0.621

High

933969

NCOA3
Nuclear receptor coactivator 3

1

20

High-throughput

0.621

High

933941

NCOA6
Nuclear receptor coactivator 6

2

20

Small-scale

0.609

High

933943

MED1
Mediator of RNA polymerase II transcription subunit 1

2

20

Small-scale

0.594

High

933967

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.594

High

933958

ROBO2
Roundabout homolog 2

1

4

High-throughput

0.587

High

788452

ACVL1
Activin receptor type-1-like

1

2

Small-scale

0.586

High

297525

PIAS1
E3 SUMO-protein ligase PIAS1

2

11

Small-scale

0.584

High

377341

NPY
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y

3

1

High-throughput

0.583

High

246498

KDM1A
Lysine-specific histone demethylase 1A

1

13

High-throughput

0.573

High

675429

TYY1
Transcriptional repressor protein YY1

1

10

High-throughput

0.541

High

807997

CDN1A
Cyclin-dependent kinase inhibitor 1

1

4

High-throughput

0.541

High

923575

TTC3
E3 ubiquitin-protein ligase TTC3

1

11

High-throughput

0.541

High

933933

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.536

High

933939

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

6

Small-scale

0.516

High

933956

SENP3
Sentrin-specific protease 3

1

3

Small-scale

0.515

High

216403

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

20

High-throughput

0.508

High

221103

SPY2
Protein sprouty homolog 2

1

5

High-throughput

0.508

High

320225

SRBS2
Sorbin and SH3 domain-containing protein 2

1

13

High-throughput

0.508

High

474578

VIME
Vimentin

1

18

High-throughput

0.508

High

933938

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.508

High

933957

RMI1
RecQ-mediated genome instability protein 1

1

1

High-throughput

0.508

High

933961

HMGX4
HMG domain-containing protein 4

1

14

High-throughput

0.508

High

933965

FAF1
FAS-associated factor 1

1

2

High-throughput

0.508

High

933966

CSAD
Cysteine sulfinic acid decarboxylase

1

3

High-throughput

0.508

High

933951

COR2A
Coronin-2A

1

20

Small-scale

0.503

High

603216

KPCA
Protein kinase C alpha type

1

11

Small-scale

0.501

High

933947

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.501

High

933962

DNM3L
DNA

1

6

Small-scale

0.501

High

933968

LAMC3
Laminin subunit gamma-3

1

4

High-throughput

0.494

High

604396

ASM
Sphingomyelin phosphodiesterase

1

0

High-throughput

0.486

High

906633

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

0

High-throughput

0.486

High

933964

DUS12
Dual specificity protein phosphatase 12

1

0

High-throughput

0.486

High

219712

FOXO3
Forkhead box protein O3

1

20

High-throughput

0.481

High

856608

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.481

High

873931

NRIP1
Nuclear receptor-interacting protein 1

1

17

High-throughput

0.481

High

933934

UBC9
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.481

High

933945

ZXDC
Zinc finger protein ZXDC

1

3

High-throughput

0.481

High

933960

ING3
Inhibitor of growth protein 3

1

11

High-throughput

0.481

High

251339

CIDEA
Lipid transferase CIDEA

1

0

Small-scale

0.480

High

128891

MEN1
Menin

1

7

Small-scale

0.479

High

219147

LTOR5
Ragulator complex protein LAMTOR5

1

2

Small-scale

0.479

High

838031

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

14

Small-scale

0.479

High

903294

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

933932

SUMO3
Small ubiquitin-related modifier 3

1

9

Small-scale

0.479

High

933940

CUL3
Cullin-3

1

11

High-throughput

0.479

High

933949

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

1

20

Small-scale

0.479

High

933952

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

20

Small-scale

0.479

High

933955

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

933935

EM55
55 kDa erythrocyte membrane protein

1

4

High-throughput

0.464

High

429128

7B2
Neuroendocrine protein 7B2

1

0

High-throughput

0.460

High

933948

ABCAC
Glucosylceramide transporter ABCA12

1

3

Small-scale

0.445

High

933954

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

3

High-throughput

0.445

High

167738

PCD17
Protocadherin-17

1

2

High-throughput

0.439

High

933959

T161A
Transmembrane protein 161A

1

2

High-throughput

0.439

High

880796

NRAM1
Natural resistance-associated macrophage protein 1

1

0

High-throughput

0.426

High

933950

NLS1
Sodium-dependent lysophosphatidylcholine symporter 1

1

0

High-throughput

0.426

High

933946

CREL2
Protein disulfide isomerase CRELD2

1

2

High-throughput

0.417

High

712094

CO4A5

1

0

High-throughput

0.265

Low

933963

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025