HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: KSP1 (P38691)
Serine/threonine-protein kinase KSP1 (EC 2.7.11.1)
Gene: KSP1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 1029
+	Hs
		437869 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPCA_HUMAN (4-412): 4.87e-126: 400: 13.19
+	Hs
		437928 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT2_HUMAN (42-418): 1.2e-127: 398: 16.41
+	Bt
		964601 HS90B_BOVIN (5-705): 0: 1022: 61.15		AKT1_BOVIN (44-409): 1.62e-127: 398: 16.06
+	Mm
		513660 HS90B_MOUSE (5-705): 0: 1025: 61.57		AKT1_MOUSE (44-411): 1.96e-126: 394: 16.75
+	Hs
		437927 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT1_HUMAN (44-411): 1.96e-126: 394: 16.75
+	Hs
		438633 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT3_HUMAN (3-421): 3.39e-126: 394: 15.08
+	Hs
		431510 HS90A_HUMAN (4-705): 0: 1013: 60.67		KPCA_HUMAN (4-412): 4.87e-126: 400: 13.19
+	Rn
		812703 HS90A_RAT (4-705): 0: 1014: 60.59		AKT1_RAT (44-411): 2.84e-126: 394: 16.75
+	Rn
		709234 HS90B_RAT (5-705): 0: 1025: 61.57		AAPK1_RAT (64-609): 1.12e-119: 380: 15.33
+	Hs
		438123 HS90B_HUMAN (5-705): 0: 1022: 61.15		AAPK1_HUMAN (64-609): 9.19e-121: 382: 15.51
+	Hs
		116958 HS90B_HUMAN (5-705): 0: 1022: 61.15		SGK1_HUMAN (2-396): 1.03e-121: 381: 16.10
+	Hs
		116956 HS90A_HUMAN (4-705): 0: 1013: 60.67		SGK1_HUMAN (2-396): 1.03e-121: 381: 16.10
+	Rn
		871252 HS90A_RAT (4-705): 0: 1014: 60.59		AAPK1_RAT (64-609): 1.12e-119: 380: 15.33
+	Hs
		438026 HS90B_HUMAN (5-705): 0: 1022: 61.15		AAPK2_HUMAN (75-377): 8.35e-77: 264: 22.36
+	Hs
		438277 HS90B_HUMAN (5-705): 0: 1022: 61.15		ULK3_HUMAN (111-335): 1.01e-19: 95.5: 32.07
+	Hs
		437842 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPSH1_HUMAN (143-335): 1.23e-17: 88.6: 30.00
+	Hs
		262221 HS90B_HUMAN (5-705): 0: 1022: 61.15		ULK1_HUMAN (143-301): 2.1e-16: 86.7: 33.53
+	Hs
		438629 HS90B_HUMAN (5-705): 0: 1022: 61.15		AURKC_HUMAN (134-296): 3.71e-17: 85.5: 31.95
+	Hs
		431475 HS90A_HUMAN (4-705): 0: 1013: 60.67		KPSH1_HUMAN (143-335): 1.23e-17: 88.6: 30.00
+	Hs
		262219 HS90A_HUMAN (4-705): 0: 1013: 60.67		ULK1_HUMAN (143-301): 2.1e-16: 86.7: 33.53