HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: PDK1 (P40530)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial (PDK 1) (Pyruvate dehydrogenase kinase 1) (EC 2.7.11.2) (Protein kinase of PDH protein 1) (Pyruvate dehydrogenase complex kinase 1) (PDC kinase 1) ([Pyruvate dehydrogenase [lipoamide]] kinase 1)
Gene: PKP1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HATPase_c~HSP90
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 394
+	Hs
		438183 HS90B_HUMAN (5-705): 0: 1022: 61.15		PDK2_HUMAN (45-390): 7.47e-160: 457: 20.56
+	Hs
		438215 HS90B_HUMAN (5-705): 0: 1022: 61.15		PDK4_HUMAN (45-390): 2.73e-158: 453: 20.50
+	Hs
		431865 HS90A_HUMAN (4-705): 0: 1013: 60.67		PDK2_HUMAN (45-390): 7.47e-160: 457: 20.56
+	Hs
		431902 HS90A_HUMAN (4-705): 0: 1013: 60.67		PDK4_HUMAN (45-390): 2.73e-158: 453: 20.50
+	Hs
		438184 HS90B_HUMAN (5-705): 0: 1022: 61.15		PDK3_HUMAN (45-390): 1.66e-154: 443: 22.72
+	Hs
		431866 HS90A_HUMAN (4-705): 0: 1013: 60.67		PDK3_HUMAN (45-390): 1.66e-154: 443: 22.72
+	Hs
		157283 HS90B_HUMAN (5-705): 0: 1022: 61.15		BCKD_HUMAN (50-383): 1.4e-127: 375: 26.01
+	Hs
		157282 HS90A_HUMAN (4-705): 0: 1013: 60.67		BCKD_HUMAN (50-383): 1.4e-127: 375: 26.01
+	Sc
		366625 HSP82_YEAST (1-705): 0: 968: 95.63		PDK2_YEAST (33-345): 8.92e-95: 293: 21.52