Protein: RRP44
Exosome complex exonuclease DIS3 (EC 3.1.13.-) (EC 3.1.26.-) (Chromosome disjunction protein 3) (Ribosomal RNA-processing protein 44)

Gene: RRP44, DIS3
Organism: Saccharomyces cerevisiae S288C
Interactions: 120
UniProt ID: Q08162

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918904

RRP46
Exosome complex component RRP46

15

16

Small-scale

0.983

High

863145

RRP41
Exosome complex component SKI6

12

20

Small-scale

0.982

High

672966

RRP43
Exosome complex component RRP43

12

1

Small-scale

0.981

High

1051718

RRP45
Exosome complex component RRP45

11

19

Small-scale

0.977

High

871134

MTR3
Exosome complex component MTR3

9

0

Small-scale

0.922

High

804759

RRP4
Exosome complex component RRP4

14

13

Small-scale

0.761

High

1061958

RRP6
Exosome complex exonuclease RRP6

14

5

Small-scale

0.760

High

923993

CSL4
Exosome complex component CSL4

13

4

Small-scale

0.760

High

1061961

RRP42
Exosome complex component RRP42

11

19

Small-scale

0.757

High

1061950

RRP40
Exosome complex component RRP40

11

4

Small-scale

0.756

High

1061951

SKI7
Superkiller protein 7

9

2

Small-scale

0.752

High

804967

LRP1
Exosome complex protein LRP1

8

0

Small-scale

0.716

High

1039056

IMA1
Importin subunit alpha

3

2

Small-scale

0.678

High

1061949

RRP44
Exosome complex exonuclease DIS3

1

5

High-throughput

0.665

High

922958

MPP6
M-phase phosphoprotein 6 homolog

4

0

Small-scale

0.653

High

527847

HSP72
Heat shock protein SSA2

3

5

Small-scale

0.650

High

918841

UTP22
U3 small nucleolar RNA-associated protein 22

3

1

High-throughput

0.643

High

798331

ENP1
Essential nuclear protein 1

3

1

High-throughput

0.640

High

1046062

DHR1
Probable ATP-dependent RNA helicase DHR1

3

5

High-throughput

0.640

High

921612

NRD1
Protein NRD1

3

0

Small-scale

0.628

High

1050187

RRP5
rRNA biogenesis protein RRP5

1

2

High-throughput

0.618

High

525353

HSP71
Heat shock protein SSA1

2

5

Small-scale

0.611

High

546524

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.601

High

522358

MPPB
Mitochondrial-processing peptidase subunit beta

2

1

High-throughput

0.588

High

671186

SIS1
Protein SIS1

2

1

Small-scale

0.584

High

844640

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

1046808

UTP14
U3 small nucleolar RNA-associated protein 14

2

1

High-throughput

0.584

High

1055500

NOC4
Nucleolar complex protein 4

2

4

High-throughput

0.584

High

735199

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.576

High

745899

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

Small-scale

0.552

High

819968

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

1053872

IMB1
Importin subunit beta-1

1

0

Small-scale

0.537

High

1042388

GCN5
Histone acetyltransferase GCN5

1

5

High-throughput

0.536

High

402244

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

3

High-throughput

0.515

High

459173

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.515

High

602661

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

641449

RCC1
Guanine nucleotide exchange factor SRM1

1

1

Small-scale

0.501

High

1043541

SKY1
Serine/threonine-protein kinase SKY1

1

1

High-throughput

0.501

High

449019

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.493

High

609202

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.493

High

632298

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.493

High

674432

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.493

High

781695

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.493

High

864924

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.493

High

1046289

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.493

High

542994

CDC24
Cell division control protein 24

1

0

Small-scale

0.480

High

149984

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

436203

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

594604

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

673243

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

677590

KRR1
KRR1 small subunit processome component

1

3

High-throughput

0.479

High

678475

PWP2
Periodic tryptophan protein 2

1

5

High-throughput

0.479

High

708366

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

747057

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

4

High-throughput

0.479

High

754347

DCA13
Protein SOF1

1

4

High-throughput

0.479

High

758419

UTP11
U3 small nucleolar RNA-associated protein 11

1

1

High-throughput

0.479

High

763640

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

817646

UTP7
U3 small nucleolar RNA-associated protein 7

1

4

High-throughput

0.479

High

823400

UTP18
U3 small nucleolar RNA-associated protein 18

1

1

High-throughput

0.479

High

852617

ROK1
ATP-dependent RNA helicase ROK1

1

5

High-throughput

0.479

High

864533

MTR4
ATP-dependent RNA helicase DOB1

1

9

High-throughput

0.479

High

865185

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

1

High-throughput

0.479

High

871068

NOL10
Ribosome biogenesis protein ENP2

1

1

High-throughput

0.479

High

924648

NAT10
RNA cytidine acetyltransferase

1

3

High-throughput

0.479

High

925209

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

3

High-throughput

0.479

High

1039867

UTP17
NET1-associated nuclear protein 1

1

7

High-throughput

0.479

High

1044313

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

1045066

MUS81
Crossover junction endonuclease MUS81

1

1

High-throughput

0.479

High

1045117

UTP5
U3 small nucleolar RNA-associated protein 5

1

6

High-throughput

0.479

High

1046266

UTP15
U3 small nucleolar RNA-associated protein 15

1

5

High-throughput

0.479

High

1051169

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

1053123

UTP13
U3 small nucleolar RNA-associated protein 13

1

8

High-throughput

0.479

High

1053526

UTP21
U3 small nucleolar RNA-associated protein 21

1

6

High-throughput

0.479

High

1054547

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

1

High-throughput

0.479

High

1055438

RRP9
Ribosomal RNA-processing protein 9

1

10

High-throughput

0.479

High

1056318

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

1056488

UTP4
U3 small nucleolar RNA-associated protein 4

1

5

High-throughput

0.479

High

1061954

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.479

High

1061955

FCF2
rRNA-processing protein FCF2

1

1

High-throughput

0.479

High

1061956

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1061957

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

1061960

UTP12
U3 small nucleolar RNA-associated protein 12

1

6

High-throughput

0.479

High

1061962

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

1061963

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

1061965

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

512686

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

609084

SKI3
Superkiller protein 3

1

0

High-throughput

0.458

High

738132

AEP1
ATPase expression protein 1, mitochondrial

1

0

High-throughput

0.458

High

776660

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

806588

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

825092

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

826222

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

919186

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

924797

NM111
Pro-apoptotic serine protease NMA111

1

0

High-throughput

0.458

High

1036422

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

1044794

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1061637

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1061952

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1061959

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1061964

ISD11
Protein ISD11

1

0

High-throughput

0.458

High

382386

H4
Histone H4

1

2

High-throughput

0.445

High

481788

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

510866

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

752815

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

804510

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

1044600

HMO1
High mobility group protein 1

1

2

High-throughput

0.445

High

753620

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

763858

SKI2
Antiviral helicase SKI2

1

8

High-throughput

0.437

High

874563

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

1061953

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

590225

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

3

High-throughput

0.417

High

924508

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

660519

HXT2
High-affinity glucose transporter HXT2

1

0

High-throughput

0.249

Low

828604

OPT1
Oligopeptide transporter 1

1

0

High-throughput

0.249

Low

1043926

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

1048782

GFD1
mRNA transport factor GFD1

1

0

High-throughput

0.249

Low

1052208

NCW2
Cell wall biogenesis protein NCW2

1

0

High-throughput

0.249

Low

746178

SEC8
Exocyst complex component SEC8

1

0

High-throughput

0.232

Low

811183

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025