Protein: RRP44
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)

Gene: RRP44, DIS3
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q9Y2L1

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1384052

EXOS8
Exosome complex component RRP43

2

19

Small-scale

0.806

High

1446209

EXOS4
Exosome complex component RRP41

2

19

Small-scale

0.789

High

1447243

EXOS5
Exosome complex component RRP46

2

20

Small-scale

0.776

High

1054527

EXOS9
Exosome complex component RRP45

1

20

Small-scale

0.691

High

1137688

EXOS7
Exosome complex component RRP42

1

19

Small-scale

0.691

High

1032271

EXOSX
Exosome complex component 10

4

5

Small-scale

0.687

High

1287704

RBM23
Probable RNA-binding protein 23

3

1

High-throughput

0.667

High

1447262

EXOS3
Exosome complex component RRP40

3

4

Small-scale

0.657

High

221304

DCX
Neuronal migration protein doublecortin

3

0

High-throughput

0.638

High

1416436

SSBP3
Single-stranded DNA-binding protein 3

3

0

High-throughput

0.638

High

1119083

C1D
Nuclear nucleic acid-binding protein C1D

2

1

High-throughput

0.628

High

1399311

MUS81
Structure-specific endonuclease subunit MUS81

2

1

High-throughput

0.628

High

1118358

EXOS2
Exosome complex component RRP4

2

5

Small-scale

0.628

High

1114701

CUL3
Cullin-3

2

1

High-throughput

0.611

High

1358225

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1371155

DLX4
Homeobox protein DLX-4

2

0

High-throughput

0.602

High

615607

NELFE
Negative elongation factor E

2

0

High-throughput

0.585

High

1335084

SERB1
SERPINE1 mRNA-binding protein 1

2

0

High-throughput

0.585

High

373547

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

414887

P53
Cellular tumor antigen p53

2

1

High-throughput

0.584

High

1434775

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

0

High-throughput

0.576

High

1490810

RRP44
Exosome complex exonuclease RRP44

1

5

Small-scale

0.575

High

243335

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1327818

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

274812

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

679296

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.536

High

911438

IMA5
Importin subunit alpha-5

1

2

High-throughput

0.536

High

1141434

WDR43
WD repeat-containing protein 43

1

6

High-throughput

0.536

High

1307537

RBM45
RNA-binding protein 45

1

2

High-throughput

0.536

High

1315268

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.536

High

1322870

EID3
EP300-interacting inhibitor of differentiation 3

1

1

High-throughput

0.536

High

1371902

CUL5
Cullin-5

1

1

High-throughput

0.536

High

1383897

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

1405177

MPH6
M-phase phosphoprotein 6

1

1

High-throughput

0.536

High

1490812

EXOS1
Exosome complex component CSL4

1

10

Small-scale

0.536

High

1209812

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.528

High

155138

SOCS2
Suppressor of cytokine signaling 2

1

1

High-throughput

0.515

High

156098

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.515

High

158520

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

290799

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

298249

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

709029

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

946476

MTPN
Myotrophin

1

0

High-throughput

0.513

High

1214386

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1226012

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

1310537

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1338648

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

0

High-throughput

0.513

High

1369090

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1405075

SORT
Sortilin

1

0

High-throughput

0.513

High

1412639

PIMRE
Protein PIMREG

1

0

High-throughput

0.513

High

1416002

YJU2
Splicing factor YJU2

1

0

High-throughput

0.513

High

1420175

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

1420268

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1439310

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

1446326

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1450395

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1451533

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

1451897

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.513

High

1458920

ZN212
Zinc finger protein 212

1

0

High-throughput

0.513

High

1462530

TRI35
E3 ubiquitin-protein ligase TRIM35

1

0

High-throughput

0.513

High

1490814

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

1068341

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

1143312

PLEC
Plectin

1

0

High-throughput

0.493

High

1490762

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

1094515

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

High-throughput

0.486

High

1415021

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

High-throughput

0.486

High

260632

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

326107

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

346527

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

386379

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

590072

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

714534

PML
Protein PML

1

1

High-throughput

0.479

High

838812

MTREX
Exosome RNA helicase MTR4

1

8

Small-scale

0.479

High

883371

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

1025530

CDK5
Cyclin-dependent kinase 5

1

3

High-throughput

0.479

High

1067860

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1089072

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1127260

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1138776

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1156439

SEPT7
Septin-7

1

1

High-throughput

0.479

High

1161270

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

1227741

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

1280622

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1380270

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1407963

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1429085

AICDA
Single-stranded DNA cytosine deaminase

1

3

Small-scale

0.479

High

1448252

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1462505

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

1490624

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.479

High

1490811

SHLB1
Endophilin-B1

1

1

High-throughput

0.479

High

129572

MEN1
Menin

1

0

High-throughput

0.458

High

246319

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.458

High

279542

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

364060

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

538149

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

607240

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

648253

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

696909

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

731719

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

766959

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

769557

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

787270

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

791859

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

879635

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

925995

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

964084

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.458

High

971316

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1013187

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

1107353

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1121381

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1135866

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1178473

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1201298

EAPP
E2F-associated phosphoprotein

1

0

Small-scale

0.458

High

1247050

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1289738

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1367762

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

1385410

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

1397576

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1414949

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

1417108

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1418537

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1429404

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1432731

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

1438256

RHOF
Rho-related GTP-binding protein RhoF

1

0

High-throughput

0.458

High

1448926

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

1453184

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1453560

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1459369

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1459533

TES
Testin

1

0

High-throughput

0.458

High

142447

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.445

High

231655

PRKY
Putative serine/threonine-protein kinase PRKY

1

1

High-throughput

0.445

High

273957

CNOT3
CCR4-NOT transcription complex subunit 3

1

1

High-throughput

0.445

High

430533

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1448584

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

128518

RN103
E3 ubiquitin-protein ligase RNF103

1

1

High-throughput

0.437

High

412844

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1256171

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1400430

LMTK3
Serine/threonine-protein kinase LMTK3

1

3

High-throughput

0.437

High

1434274

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1450366

SEP11
Septin-11

1

1

High-throughput

0.437

High

375029

RASH
GTPase HRas

1

0

High-throughput

0.426

High

1130536

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1417630

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.426

High

628477

KLK2
Kallikrein-2

1

1

High-throughput

0.407

High

1397196

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.407

High

1404997

GA2L1
GAS2-like protein 1

3

0

High-throughput

0.347

High

387922

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

424567

PAI2
Plasminogen activator inhibitor 2

2

0

High-throughput

0.328

High

416051

CP1A1
Cytochrome P450 1A1

2

0

High-throughput

0.318

High

1384095

ZN428
Zinc finger protein 428

2

0

High-throughput

0.313

High

62783

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.279

Low

471570

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.279

Low

1329559

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1331805

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1332320

F181A
Protein FAM181A

1

0

High-throughput

0.279

Low

1390452

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

1402746

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1462676

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.279

Low

1490813

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

48260

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.249

Low

106890

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

294552

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

720368

UFO
Tyrosine-protein kinase receptor UFO

1

0

High-throughput

0.249

Low

1242063

SCYL2
SCY1-like protein 2

1

0

High-throughput

0.249

Low

1324116

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1327284

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1332921

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1348257

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1391935

RN185
E3 ubiquitin-protein ligase RNF185

1

0

High-throughput

0.249

Low

1393840

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1459821

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

295657

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

1197908

S39AC
Zinc transporter ZIP12

1

0

High-throughput

0.232

Low

1384612

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.232

Low

1399950

FACOS
FANCD2 opposite strand protein

1

0

High-throughput

0.232

Low

1447618

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025