HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: RUVB1 (Q03940)
RuvB-like protein 1 (RUVBL1) (EC 3.6.4.12) (TIP49-homology protein 1) (TIP49a homolog)
Gene: RVB1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	26831523, 31399574, 19536198, 15766533
Identification Methods	affinity chromatography technology, biochemical, pull down, tandem affinity purification
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000492 - box C/D snoRNP assembly GO:0005524 - ATP binding GO:0016887 - ATP hydrolysis activity GO:0050821 - protein stabilization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 463
+	Hs
		438632 HS90B_HUMAN (5-705): 0: 1022: 61.15		RUVB2_HUMAN (1-458): 0: 637: 41.09
+	Sc
		366829 HSP82_YEAST (1-705): 0: 968: 95.63		RUVB1_YEAST (1-463): 0: 682: 100.00
+	Hs
		432374 HS90A_HUMAN (4-705): 0: 1013: 60.67		RUVB2_HUMAN (1-458): 0: 637: 41.09
+	Ca
		804508 HSP90_CANAL (4-705): 0: 953: 82.36		RUVB1_CANAL (1-463): 0: 661: 78.45
+	Sc
		544639 HSC82_YEAST (1-705): 0: 977: 100.00		RUVB2_YEAST (15-463): 0: 622: 41.15
+	Sc
		367127 HSP82_YEAST (1-705): 0: 968: 95.63		RUVB2_YEAST (15-463): 0: 622: 41.15
+	Ca
		804543 HSP90_CANAL (4-705): 0: 953: 82.36		RUVB2_CANAL (21-461): 0: 618: 41.99