Protein: CP51
Lanosterol 14-alpha demethylase CYP51 (EC 1.14.14.154) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (CYPLI) (Ergosterol biosynthetic protein 11) (Lanosterol C14-C32 lyase) (Sterol 14-alpha demethylase)

Gene: CP51, ERG11
Organism: Saccharomyces cerevisiae S288C
Interactions: 117
UniProt ID: P10614

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006696 - ergosterol biosynthetic process
GO:0008398 - sterol 14-demethylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

495781

CP51
Lanosterol 14-alpha demethylase CYP51

2

11

Small-scale

0.815

High

495785

NCPR
NADPH--cytochrome P450 reductase

1

4

High-throughput

0.698

High

495861

ERG5
C-22 sterol desaturase ERG5

1

11

High-throughput

0.698

High

495846

STE24
CAAX prenyl protease 1

2

1

High-throughput

0.632

High

495851

ERG25
C-4 methylsterol oxidase ERG25

2

3

Small-scale

0.632

High

495808

ERG24
Delta(14)-sterol reductase ERG24

2

2

Small-scale

0.614

High

495832

ERG28
Ergosterol biosynthetic protein 28

2

0

Small-scale

0.609

High

495790

EPT1
Choline/ethanolaminephosphotransferase 1

2

1

High-throughput

0.608

High

495798

LAC1
Ceramide synthase LAC1

2

0

High-throughput

0.605

High

495820

PHO88
SRP-independent targeting protein 3

2

0

High-throughput

0.588

High

495806

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

2

3

Small-scale

0.576

High

495860

ASI1
ERAD-associated E3 ubiquitin-protein ligase ASI1

2

1

Small-scale

0.558

High

495786

CPT1
Cholinephosphotransferase 1

1

1

High-throughput

0.541

High

495787

HNM1
Choline transport protein

1

3

High-throughput

0.541

High

495788

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.541

High

495792

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

495794

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

Small-scale

0.541

High

495795

ELO2
Fatty acid elongase 2

1

2

High-throughput

0.541

High

495807

YBT1
ATP-dependent bile acid permease

1

1

High-throughput

0.541

High

495828

SUR2
Sphingolipid C4-hydroxylase SUR2

1

3

High-throughput

0.541

High

495838

GST1
Glutathione S-transferase 1

1

1

High-throughput

0.541

High

495845

SPC1
Signal peptidase complex subunit 1

1

2

High-throughput

0.541

High

495853

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

3

Small-scale

0.541

High

495862

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.541

High

495864

OSH6
Oxysterol-binding protein homolog 6

1

2

High-throughput

0.541

High

495867

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

3

High-throughput

0.541

High

495877

ERP1
Protein ERP1

1

2

High-throughput

0.541

High

495885

SAM3
S-adenosylmethionine permease SAM3

1

2

High-throughput

0.541

High

495888

RTN2
Reticulon-like protein 2

1

5

High-throughput

0.541

High

495889

ERG27
3-keto-steroid reductase ERG27

1

2

Small-scale

0.541

High

400165

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.518

High

411155

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.518

High

495789

SEC62
Translocation protein SEC62

1

0

High-throughput

0.518

High

495801

ERG9
Squalene synthase ERG9

1

0

Small-scale

0.518

High

495803

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.518

High

495812

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.518

High

495813

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.518

High

495822

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.518

High

495823

ERG7
Lanosterol synthase ERG7

1

0

Small-scale

0.518

High

495830

SOP4
Protein SOP4

1

0

High-throughput

0.518

High

495836

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.518

High

495839

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.518

High

495840

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.518

High

495843

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

495844

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

495847

ILM1
Protein ILM1

1

0

High-throughput

0.518

High

495849

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

495854

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.518

High

495865

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.518

High

495866

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.518

High

495869

PKR1
V-type ATPase assembly factor PKR1

1

0

High-throughput

0.518

High

495871

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.518

High

495876

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.518

High

495880

ORM2
Protein ORM2

1

0

High-throughput

0.518

High

495881

ARV1
Protein ARV1

1

0

High-throughput

0.518

High

495890

SEY1
Protein SEY1

1

0

High-throughput

0.518

High

495784

DAL5
Allantoate permease

1

2

High-throughput

0.494

High

495814

KES1
Oxysterol-binding protein homolog 4

1

2

High-throughput

0.494

High

495815

SIS2
Phosphopantothenoylcysteine decarboxylase subunit SIS2

1

2

High-throughput

0.494

High

495818

CAB3
Coenzyme A biosynthesis protein 3

1

2

High-throughput

0.494

High

495824

COS8
Protein COS8

1

2

High-throughput

0.494

High

495842

COS4
Protein COS4

1

2

High-throughput

0.494

High

495852

YOR1
Oligomycin resistance ATP-dependent permease YOR1

1

2

High-throughput

0.494

High

495855

COS6
Protein COS6

1

2

High-throughput

0.494

High

495882

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

2

High-throughput

0.494

High

495887

TPO4
Polyamine transporter 4

1

3

High-throughput

0.494

High

495858

ASI2
Protein ASI2

1

0

Small-scale

0.493

High

495834

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

4

Small-scale

0.479

High

495848

HLJ1
Protein HLJ1

1

3

High-throughput

0.479

High

495875

RTN1
Reticulon-like protein 1

1

5

Small-scale

0.479

High

495859

ASI3
Probable ERAD-associated E3 ubiquitin-protein ligase ASI1

1

1

Small-scale

0.470

High

495810

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.458

High

495891

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

477082

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

7

High-throughput

0.457

High

495874

ERV41
ER-derived vesicles protein ERV41

1

1

High-throughput

0.457

High

495805

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.438

High

495884

FLC1
Flavin carrier protein 1

1

0

High-throughput

0.438

High

495783

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

495793

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

495800

BMH1
Protein BMH1

1

2

High-throughput

0.437

High

495802

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

495833

IMB4
Importin subunit beta-4

1

1

High-throughput

0.437

High

495868

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.437

High

495879

IMB1
Importin subunit beta-1

1

1

High-throughput

0.437

High

495883

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

495826

ATC2
Calcium-transporting ATPase 2

1

3

High-throughput

0.417

High

365659

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.407

High

490123

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

495782

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

495835

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

495797

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.282

High

495799

TRK2
Low-affinity potassium transport protein

1

0

High-throughput

0.282

High

495809

HXT1
Low-affinity glucose transporter HXT1

1

0

High-throughput

0.282

High

495816

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.282

High

495817

MNN4
Protein MNN4

1

0

High-throughput

0.282

High

495825

SHU1
Suppressor of HU sensitivity involved in recombination protein 1

1

0

High-throughput

0.282

High

495827

SRP14
Signal recognition particle subunit SRP14

1

0

High-throughput

0.282

High

495837

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

0

High-throughput

0.282

High

495850

AVT4
Vacuolar amino acid transporter 4

1

0

High-throughput

0.282

High

495856

TOM7
Mitochondrial import receptor subunit TOM7

1

0

High-throughput

0.282

High

495886

ENG2
Glucan endo-1,3-beta-D-glucosidase 2

1

0

High-throughput

0.282

High

495811

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.269

Low

495791

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

495804

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

495819

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

495829

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

495831

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.249

Low

495841

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

495857

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

495863

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.249

Low

495870

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

495872

SXM1
Importin beta SMX1

1

0

High-throughput

0.249

Low

495873

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

495878

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

495821

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

0

High-throughput

0.238

Low

495796

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024