HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: RTK1 (Q12100)
Probable serine/threonine-protein kinase RTK1 (EC 2.7.11.1) (Ribosome biogenesis and tRNA synthetase-associated kinase 1)
Gene: RTK1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	19536198, 15766533
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 620
+	Hs
		438130 HS90B_HUMAN (5-705): 0: 1022: 61.15		M3K1_HUMAN (107-578): 9.61e-126: 406: 22.42
+	Hs
		431808 HS90A_HUMAN (4-705): 0: 1013: 60.67		M3K1_HUMAN (107-578): 9.61e-126: 406: 22.42
+	Hs
		437908 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK2_HUMAN (300-581): 5.86e-130: 385: 23.03
+	Hs
		431549 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK2_HUMAN (300-581): 5.86e-130: 385: 23.03
+	Hs
		438075 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK3_HUMAN (300-582): 5.27e-126: 375: 23.93
+	Mm
		513660 HS90B_MOUSE (5-705): 0: 1025: 61.57		AKT1_MOUSE (230-612): 1.92e-122: 372: 17.38
+	Bt
		964601 HS90B_BOVIN (5-705): 0: 1022: 61.15		AKT1_BOVIN (230-612): 5.81e-123: 374: 17.88
+	Hs
		437927 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT1_HUMAN (230-612): 2.52e-122: 372: 17.63
+	Hs
		437928 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT2_HUMAN (230-612): 1.96e-122: 372: 17.42
+	Hs
		438633 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT3_HUMAN (230-612): 1.92e-122: 372: 17.42
+	Hs
		431741 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK3_HUMAN (300-582): 5.27e-126: 375: 23.93
+	Rn
		812703 HS90A_RAT (4-705): 0: 1014: 60.59		AKT1_RAT (230-612): 1.11e-122: 373: 17.63
+	Hs
		431572 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT1_HUMAN (230-612): 2.52e-122: 372: 17.63
+	Hs
		431573 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT2_HUMAN (230-612): 1.96e-122: 372: 17.42
+	Hs
		432376 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT3_HUMAN (230-612): 1.92e-122: 372: 17.42
+	Mm
		432411 HS90A_MOUSE (4-705): 0: 1012: 60.59		AKT1_MOUSE (230-612): 1.92e-122: 372: 17.38
+	Sc
		543212 HSC82_YEAST (1-705): 0: 977: 100.00		NPR1_YEAST (315-606): 1.19e-72: 250: 43.64
+	Hs
		154118 HS90B_HUMAN (5-705): 0: 1022: 61.15		CHK1_HUMAN (306-601): 8.53e-28: 119: 28.15
+	Hs
		154117 HS90A_HUMAN (4-705): 0: 1013: 60.67		CHK1_HUMAN (306-601): 8.53e-28: 119: 28.15
+	Sc
		543730 HSC82_YEAST (1-705): 0: 977: 100.00		HAL5_YEAST (273-583): 3.16e-27: 119: 26.44