HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: SMC6 (Q12749)
Structural maintenance of chromosomes protein 6 (DNA repair protein RHC18) (Rad18 homolog)
Gene: SMC6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	11805837, 33301732
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0016887 - ATP hydrolysis activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 1114
+	Sc
		367151 HSP82_YEAST (1-705): 0: 968: 95.63		SMC6_YEAST (1-1114): 1.03e-104: 357: 100.00
+	Hs
		438338 HS90B_HUMAN (5-705): 0: 1022: 61.15		SMC5_HUMAN (35-1112): 5.81e-68: 250: 13.95
+	Hs
		432040 HS90A_HUMAN (4-705): 0: 1013: 60.67		SMC5_HUMAN (35-1112): 5.81e-68: 250: 13.95
+	Hs
		432296 HS90A_HUMAN (4-705): 0: 1013: 60.67		SMC4_HUMAN (5-1100): 2.66e-60: 228: 11.78
+	Sc
		366288 HSP82_YEAST (1-705): 0: 968: 95.63		SMC2_YEAST (81-1099): 9.79e-59: 223: 12.13
+	Sc
		366996 HSP82_YEAST (1-705): 0: 968: 95.63		SMC5_YEAST (70-1096): 3.83e-57: 217: 12.68
+	Hs
		437945 HS90B_HUMAN (5-705): 0: 1022: 61.15		MYH9_HUMAN (163-770): 9.14e-23: 107: 7.54
+	Hs
		431590 HS90A_HUMAN (4-705): 0: 1013: 60.67		MYH9_HUMAN (163-770): 9.14e-23: 107: 7.54
+	Hs
		431480 HS90A_HUMAN (4-705): 0: 1013: 60.67		MYH7_HUMAN (158-708): 3.02e-13: 76.6: 8.72
+	Sc
		544000 HSC82_YEAST (1-705): 0: 977: 100.00		SMC3_YEAST (247-1081): 1.13e-13: 78: 13.05
+	Sc
		366526 HSP82_YEAST (1-705): 0: 968: 95.63		SMC3_YEAST (247-1081): 1.13e-13: 78: 13.05