Protein: TYK2
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

Gene: TYK2
Organism: Homo sapiens
Interactions: 135
UniProt ID: P29597

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181802

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.814

High

585407

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

20

Small-scale

0.806

High

665800

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.806

High

669149

STAT2
Signal transducer and activator of transcription 2

2

20

Small-scale

0.789

High

669195

LRC46
Leucine-rich repeat-containing protein 46

3

20

High-throughput

0.770

High

566003

INAR1
Interferon alpha/beta receptor 1

13

20

Small-scale

0.759

High

548650

VAV
Proto-oncogene vav

2

20

Small-scale

0.754

High

669130

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

18

Small-scale

0.754

High

412039

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.724

High

433605

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.724

High

669154

HNRPK
Heterogeneous nuclear ribonucleoprotein K

4

20

High-throughput

0.705

High

669176

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

4

20

High-throughput

0.703

High

669170

FHL3
Four and a half LIM domains protein 3

4

20

High-throughput

0.700

High

207541

RNF13
E3 ubiquitin-protein ligase RNF13

3

9

High-throughput

0.667

High

669150

EFNB2
Ephrin-B2

3

7

High-throughput

0.667

High

573586

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.665

High

669134

IL6RB
Interleukin-6 receptor subunit beta

1

20

Small-scale

0.665

High

669148

JAK3
Tyrosine-protein kinase JAK3

1

18

Small-scale

0.665

High

669164

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.665

High

669163

Q05BL1
TP53BP2 protein

1

20

High-throughput

0.665

High

669144

DYN2
Dynamin-2

1

19

High-throughput

0.656

High

669199

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.656

High

669138

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.647

High

669214

IRS2
Insulin receptor substrate 2

1

20

Small-scale

0.647

High

669156

RACK1
Small ribosomal subunit protein RACK1

2

11

Small-scale

0.631

High

515993

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.628

High

622724

IL4RA
Interleukin-4 receptor subunit alpha

2

20

High-throughput

0.628

High

669151

CADH8
Cadherin-8

2

20

High-throughput

0.628

High

669186

GP156
Probable G-protein coupled receptor 156

2

8

High-throughput

0.628

High

669189

HAVR2
Hepatitis A virus cellular receptor 2

2

4

High-throughput

0.628

High

669204

TNR19
Tumor necrosis factor receptor superfamily member 19

2

2

High-throughput

0.628

High

669168

ASPP2
Apoptosis-stimulating of p53 protein 2

1

20

High-throughput

0.621

High

669208

OPT
Opticin

1

20

High-throughput

0.618

High

146598

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.618

High

238364

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

277013

STAM2
Signal transducing adapter molecule 2

1

20

Small-scale

0.618

High

500950

GHR
Growth hormone receptor

1

20

Small-scale

0.618

High

566298

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.618

High

576990

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

High-throughput

0.618

High

616741

JAK1
Tyrosine-protein kinase JAK1

1

19

Small-scale

0.618

High

669133

TGFR2
TGF-beta receptor type-2

1

20

High-throughput

0.618

High

669139

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.618

High

669141

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

669147

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.618

High

669183

AHI1
Jouberin

1

20

Small-scale

0.618

High

669201

Q9H4D1
Protein kinase

1

20

High-throughput

0.618

High

66994

CRTP1
Cysteine-rich tail protein 1

2

3

High-throughput

0.606

High

267480

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

20

High-throughput

0.606

High

669172

K1H1
Keratin, type I cuticular Ha1

2

12

High-throughput

0.606

High

669203

PRDM5
PR domain zinc finger protein 5

2

2

High-throughput

0.606

High

156692

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

0

High-throughput

0.602

High

267128

GEMI
Geminin

2

0

High-throughput

0.602

High

669137

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

669194

IFT43
Intraflagellar transport protein 43 homolog

2

0

High-throughput

0.602

High

626769

PTAFR
Platelet-activating factor receptor

2

20

Small-scale

0.601

High

542823

BRAF
Serine/threonine-protein kinase B-raf

1

20

Small-scale

0.575

High

669152

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.575

High

669161

KPCE
Protein kinase C epsilon type

1

20

Small-scale

0.575

High

669177

K1C40
Keratin, type I cytoskeletal 40

1

11

High-throughput

0.573

High

669198

TRAF4
TNF receptor-associated factor 4

1

19

High-throughput

0.573

High

62275

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

669159

I13R1
Interleukin-13 receptor subunit alpha-1

2

20

Small-scale

0.552

High

175421

SIVA
Apoptosis regulatory protein Siva

1

1

Small-scale

0.552

High

669191

CSN5
COP9 signalosome complex subunit 5

1

8

Small-scale

0.552

High

302372

CSTN1
Calsyntenin-1

1

20

High-throughput

0.536

High

323605

BAG2
BAG family molecular chaperone regulator 2

1

7

High-throughput

0.536

High

380090

MAS
Proto-oncogene Mas

1

20

High-throughput

0.536

High

388251

HSPB1
Heat shock protein beta-1

1

7

High-throughput

0.536

High

454683

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

505343

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.536

High

571322

DDX5
Probable ATP-dependent RNA helicase DDX5

1

7

High-throughput

0.536

High

573139

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.536

High

669131

CD6
T-cell differentiation antigen CD6

1

6

High-throughput

0.536

High

669132

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

20

High-throughput

0.536

High

669135

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

669136

TPOR
Thrombopoietin receptor

1

7

High-throughput

0.536

High

669142

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

669143

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

669145

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

669146

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

669153

CXCR4
C-X-C chemokine receptor type 4

1

18

High-throughput

0.536

High

669155

RAN
GTP-binding nuclear protein Ran

1

12

High-throughput

0.536

High

669157

TBA4A
Tubulin alpha-4A chain

1

16

High-throughput

0.536

High

669158

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

669165

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.536

High

669167

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.536

High

669174

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

5

High-throughput

0.536

High

669188

WDR20
WD repeat-containing protein 20

1

15

High-throughput

0.536

High

669190

MADD
MAP kinase-activating death domain protein

1

14

High-throughput

0.536

High

669197

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

669207

NLGN3
Neuroligin-3

1

2

High-throughput

0.536

High

669210

TRAK1
Trafficking kinesin-binding protein 1

1

20

High-throughput

0.536

High

669211

RUVB2
RuvB-like 2

1

3

High-throughput

0.536

High

669212

RUVB1
RuvB-like 1

1

3

High-throughput

0.536

High

669213

C170B
Centrosomal protein of 170 kDa protein B

1

20

High-throughput

0.536

High

437921

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.515

High

669162

UPAR
Urokinase plasminogen activator surface receptor

1

4

Small-scale

0.515

High

669209

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.515

High

669175

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

669193

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

153579

ANM5
Protein arginine N-methyltransferase 5

1

12

Small-scale

0.501

High

669173

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

669160

IDD
Integral membrane protein DGCR2/IDD

1

5

High-throughput

0.489

High

669200

CSTN2
Calsyntenin-2

1

20

High-throughput

0.489

High

378638

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

150868

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

159022

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

4

Small-scale

0.479

High

164355

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

199086

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

20

Small-scale

0.479

High

319131

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

431565

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

524802

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.479

High

600088

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

610250

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

669140

LPAR6
Lysophosphatidic acid receptor 6

1

20

High-throughput

0.479

High

669166

KLF10
Krueppel-like factor 10

1

7

Small-scale

0.479

High

669169

PTC1
Protein patched homolog 1

1

1

Small-scale

0.479

High

669171

LRP8
Low-density lipoprotein receptor-related protein 8

1

4

High-throughput

0.479

High

669178

ELP2
Elongator complex protein 2

1

10

Small-scale

0.479

High

669180

THOC4
THO complex subunit 4

1

7

High-throughput

0.479

High

669184

MIER2
Mesoderm induction early response protein 2

1

4

High-throughput

0.479

High

669187

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.479

High

669196

ZN333
Zinc finger protein 333

1

4

High-throughput

0.479

High

669202

BRD7
Bromodomain-containing protein 7

1

18

High-throughput

0.479

High

669205

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

669206

MTMR4
Myotubularin-related protein 4

1

10

High-throughput

0.479

High

329400

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.470

High

669192

UBE2F
NEDD8-conjugating enzyme UBE2F

1

4

High-throughput

0.457

High

669179

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

669182

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.328

High

63995

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

68047

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

669181

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

669185

TM130
Transmembrane protein 130

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024