Protein: FBXL4
F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5)

Gene: FBXL4
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q9UKA2

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000422 - autophagy of mitochondrion
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992383

SKP1
S-phase kinase-associated protein 1

11

20

Small-scale

0.975

High

1112780

CUL1
Cullin-1

5

20

Small-scale

0.912

High

239404

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

4

1

Small-scale

0.692

High

1092101

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

4

1

Small-scale

0.692

High

582641

PPAP
Prostatic acid phosphatase

2

1

High-throughput

0.628

High

754604

S10A3
Protein S100-A3

2

1

High-throughput

0.628

High

1460979

FBXL4
F-box/LRR-repeat protein 4

1

19

Small-scale

0.618

High

63326

ODAD3
Outer dynein arm-docking complex subunit 3

3

3

High-throughput

0.609

High

1328146

TTC9C
Tetratricopeptide repeat protein 9C

3

13

Small-scale

0.609

High

609837

LEG3
Galectin-3

2

0

High-throughput

0.602

High

846034

CACP
Carnitine O-acetyltransferase

2

0

High-throughput

0.602

High

1098687

SBP1
Methanethiol oxidase

2

0

High-throughput

0.602

High

1460980

PADI3
Protein-arginine deiminase type-3

2

0

High-throughput

0.602

High

1460986

NEUR2
Sialidase-2

2

0

High-throughput

0.602

High

1392692

MYO19
Unconventional myosin-XIX

2

3

Small-scale

0.584

High

1460984

SGT1
Protein SGT1 homolog

2

16

Small-scale

0.584

High

326794

DUS14
Dual specificity protein phosphatase 14

2

3

High-throughput

0.574

High

692836

CALL3
Calmodulin-like protein 3

2

6

High-throughput

0.574

High

902406

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

2

2

High-throughput

0.574

High

1118006

PKP1
Plakophilin-1

2

3

High-throughput

0.574

High

1120986

TRI29
Tripartite motif-containing protein 29

2

3

High-throughput

0.574

High

1226838

ATG9B
Autophagy-related protein 9B

2

1

High-throughput

0.574

High

1286483

DSG4
Desmoglein-4

2

3

High-throughput

0.574

High

1353679

LRC15
Leucine-rich repeat-containing protein 15

2

20

High-throughput

0.574

High

1459701

SUN2
SUN domain-containing protein 2

2

1

High-throughput

0.574

High

1433700

TRABD
TraB domain-containing protein

2

0

Small-scale

0.559

High

1247536

POTEE
POTE ankyrin domain family member E

1

2

High-throughput

0.553

High

896925

DYN2
Dynamin-2

1

1

High-throughput

0.515

High

1118351

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

1164381

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

0

High-throughput

0.513

High

1311537

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.513

High

1212182

ODAD2
Outer dynein arm-docking complex subunit 2

1

7

High-throughput

0.489

High

1460987

PKP3
Plakophilin-3

1

4

High-throughput

0.489

High

173531

XPO1
Exportin-1

1

6

High-throughput

0.479

High

273457

KDM4A
Lysine-specific demethylase 4A

1

2

Small-scale

0.479

High

291000

PPM1B
Protein phosphatase 1B

1

1

Small-scale

0.479

High

318072

TOM70
Mitochondrial import receptor subunit TOM70

1

13

Small-scale

0.479

High

348792

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

407546

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.479

High

457764

TBB5
Tubulin beta chain

1

6

Small-scale

0.479

High

462027

HS90A
Heat shock protein HSP 90-alpha

1

13

Small-scale

0.479

High

468898

HS90B
Heat shock protein HSP 90-beta

1

15

Small-scale

0.479

High

533052

CH60
60 kDa heat shock protein, mitochondrial

1

3

Small-scale

0.479

High

535660

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.479

High

538086

HSP7C
Heat shock cognate 71 kDa protein

1

10

Small-scale

0.479

High

566229

K1C10
Keratin, type I cytoskeletal 10

1

2

Small-scale

0.479

High

641058

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

7

Small-scale

0.479

High

725678

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

1

Small-scale

0.479

High

728012

DNJA1
DnaJ homolog subfamily A member 1

1

5

Small-scale

0.479

High

731688

STIP1
Stress-induced-phosphoprotein 1

1

9

Small-scale

0.479

High

772077

K1C9
Keratin, type I cytoskeletal 9

1

1

Small-scale

0.479

High

777583

K22E
Keratin, type II cytoskeletal 2 epidermal

1

2

Small-scale

0.479

High

801576

HSPA9
Stress-70 protein, mitochondrial

1

13

Small-scale

0.479

High

881334

FAS
Fatty acid synthase

1

1

Small-scale

0.479

High

899273

TCPQ
T-complex protein 1 subunit theta

1

4

Small-scale

0.479

High

931154

HSP72
Heat shock-related 70 kDa protein 2

1

10

Small-scale

0.479

High

935269

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

953173

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

984017

RBX1
E3 ubiquitin-protein ligase RBX1

1

10

Small-scale

0.479

High

997180

TBA4A
Tubulin alpha-4A chain

1

3

Small-scale

0.479

High

997558

TBB4B
Tubulin beta-4B chain

1

6

Small-scale

0.479

High

1007335

TCPB
T-complex protein 1 subunit beta

1

5

Small-scale

0.479

High

1125727

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

12

High-throughput

0.479

High

1144325

STK38
Serine/threonine-protein kinase 38

1

3

Small-scale

0.479

High

1164620

MIC60
MICOS complex subunit MIC60

1

1

Small-scale

0.479

High

1278142

MAVS
Mitochondrial antiviral-signaling protein

1

3

High-throughput

0.479

High

1312301

MIRO2
Mitochondrial Rho GTPase 2

1

1

High-throughput

0.479

High

1312391

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

6

High-throughput

0.479

High

1366621

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1453388

MTCH1
Mitochondrial carrier homolog 1

1

5

High-throughput

0.479

High

1460982

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

7

Small-scale

0.479

High

1460989

MTCH2
Mitochondrial carrier homolog 2

1

6

High-throughput

0.479

High

573275

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

637779

FLNA
Filamin-A

1

0

Small-scale

0.458

High

732860

GLPK
Glycerol kinase

1

0

High-throughput

0.458

High

913611

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.458

High

1382978

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1448039

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1451750

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1460985

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

171014

CLGN
Calmegin

1

2

Small-scale

0.437

High

699242

CALX
Calnexin

1

2

Small-scale

0.437

High

717638

PDIA3
Protein disulfide-isomerase A3

1

1

Small-scale

0.437

High

996893

TBA1B
Tubulin alpha-1B chain

1

4

Small-scale

0.437

High

1108747

TBB3
Tubulin beta-3 chain

1

6

Small-scale

0.437

High

1118632

TBB2A
Tubulin beta-2A chain

1

6

Small-scale

0.437

High

1142428

PDIA6
Protein disulfide-isomerase A6

1

1

Small-scale

0.437

High

787721

SPB5
Serpin B5

2

0

High-throughput

0.328

High

1062315

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

0

High-throughput

0.328

High

1133861

GPNMB
Transmembrane glycoprotein NMB

2

0

High-throughput

0.328

High

1207491

CAHM4
Calcium homeostasis modulator protein 4

2

0

High-throughput

0.328

High

1236050

HPHL1
Ferroxidase HEPHL1

2

0

High-throughput

0.328

High

1286414

LYG2
Lysozyme g-like protein 2

2

0

High-throughput

0.328

High

1369663

DNSL2
Deoxyribonuclease-1-like 2

2

0

High-throughput

0.328

High

1460983

CNPY2
Protein canopy homolog 2

2

0

High-throughput

0.328

High

1460988

CRBG1
Beta/gamma crystallin domain-containing protein 1

2

0

High-throughput

0.328

High

516733

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

0

High-throughput

0.288

High

1240593

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.279

Low

1460981

EPCR
Endothelial protein C receptor

1

0

High-throughput

0.279

Low

163601

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.268

Low

1386410

FAF2
FAS-associated factor 2

1

0

Small-scale

0.249

Low

1388120

ERLEC
Endoplasmic reticulum lectin 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025