HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: AGAP2 (Q99490)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	22453919
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Ras, Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1192
+	Hs
		925551 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		AGAP2_HUMAN (1-1192): 0: 920: 100.00
+	Hs
		925736 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		AGAP1_HUMAN (387-1160): 0: 729: 54.02
+	Hs
		925724 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ASAP1_HUMAN (723-1185): 5.63e-94: 328: 21.94
+	Hs
		892677 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ASAP1_HUMAN (723-1185): 5.63e-94: 328: 21.94
+	Hs
		925478 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ARAP2_HUMAN (579-1113): 2.68e-83: 301: 19.96
+	Hs
		892516 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ARAP2_HUMAN (579-1113): 2.68e-83: 301: 19.96
+	Hs
		925274 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GIT2_HUMAN (938-1145): 5.51e-73: 260: 31.98
+	Hs
		918847 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		RAB1A_HUMAN (396-605): 7.9e-79: 259: 18.89
+	Hs
		925751 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		GIT1_HUMAN (938-1145): 1.39e-71: 257: 32.88
+	Gg
		1154344 Q6LC82_CHICK (1-192): 1.69e-84: 249: 92.19		Q9DG15_CHICK (938-1145): 1.93e-71: 256: 33.78
+	Hs
		564527 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		GIT2_HUMAN (938-1145): 5.51e-73: 260: 31.98
+	Hs
		545371 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		GIT2_HUMAN (938-1145): 5.51e-73: 260: 31.98
+	Hs
		564470 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		RAB1A_HUMAN (396-605): 7.9e-79: 259: 18.89
+	Hs
		545307 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		RAB1A_HUMAN (396-605): 7.9e-79: 259: 18.89
+	Hs
		564752 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		GIT1_HUMAN (938-1145): 1.39e-71: 257: 32.88
+	Hs
		545710 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		GIT1_HUMAN (938-1145): 1.39e-71: 257: 32.88
+	Hs
		892368 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		GIT2_HUMAN (938-1145): 5.51e-73: 260: 31.98
+	Hs
		892305 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		RAB1A_HUMAN (396-605): 7.9e-79: 259: 18.89
+	Hs
		892692 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		GIT1_HUMAN (938-1145): 1.39e-71: 257: 32.88
+	Hs
		925529 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ARAP1_HUMAN (852-1110): 1.31e-64: 242: 28.14