Protein: PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)

Gene: PP6R1, PPP6R1
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q9UPN7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0009966 - regulation of signal transduction
GO:0019888 - protein phosphatase regulator activity
GO:0019903 - protein phosphatase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

143715

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

10

9

Small-scale

0.758

High

1131154

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

4

4

High-throughput

0.694

High

1331021

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

7

9

Small-scale

0.682

High

177338

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

9

Small-scale

0.675

High

920368

PLK1
Serine/threonine-protein kinase PLK1

3

12

High-throughput

0.656

High

1227717

A16L1
Autophagy-related protein 16-1

3

10

High-throughput

0.633

High

1316074

TRM2A
tRNA

2

2

High-throughput

0.628

High

1407019

NPAS1
Neuronal PAS domain-containing protein 1

2

4

High-throughput

0.628

High

1008402

PRKDC
DNA-dependent protein kinase catalytic subunit

2

5

Small-scale

0.624

High

1273133

MOB1B
MOB kinase activator 1B

2

8

High-throughput

0.621

High

1371095

ARHG2
Rho guanine nucleotide exchange factor 2

2

3

Small-scale

0.621

High

1204822

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

2

6

High-throughput

0.611

High

1326242

PNKD
Probable thioesterase PNKD

2

1

High-throughput

0.611

High

1333093

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

3

9

Small-scale

0.609

High

568020

PRG2
Bone marrow proteoglycan

3

2

High-throughput

0.609

High

1402692

DCR1C
Protein artemis

3

1

High-throughput

0.599

High

538126

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.588

High

127797

IKBE
NF-kappa-B inhibitor epsilon

2

14

Small-scale

0.584

High

891891

GSK3B
Glycogen synthase kinase-3 beta

2

11

High-throughput

0.584

High

1436460

MOB1A
MOB kinase activator 1A

2

8

High-throughput

0.584

High

466988

ACM4
Muscarinic acetylcholine receptor M4

2

2

High-throughput

0.574

High

1101710

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

4

High-throughput

0.549

High

407143

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

469848

CATG
Cathepsin G

1

2

High-throughput

0.536

High

857595

NOTC1
Neurogenic locus notch homolog protein 1

1

12

High-throughput

0.536

High

872893

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.536

High

906218

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.536

High

1257845

ACD11
Acyl-CoA dehydrogenase family member 11

1

2

High-throughput

0.536

High

1340073

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

2

High-throughput

0.536

High

1350987

BRSK1
Serine/threonine-protein kinase BRSK1

1

8

High-throughput

0.536

High

1387295

HDA11
Histone deacetylase 11

1

10

High-throughput

0.536

High

1405262

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

8

High-throughput

0.536

High

1448564

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

1451426

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

5

High-throughput

0.536

High

1461800

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.536

High

1408424

SH3G3
Endophilin-A3

2

8

High-throughput

0.521

High

831654

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

1405155

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.515

High

1040238

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.513

High

1157164

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

1370609

FGF14
Fibroblast growth factor 14

1

0

High-throughput

0.513

High

1429699

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.513

High

1408401

SH3G2
Endophilin-A1

1

9

High-throughput

0.508

High

989170

AP2B1
AP-2 complex subunit beta

1

10

High-throughput

0.501

High

50731

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.489

High

133322

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.489

High

182835

GP182
G-protein coupled receptor 182

1

6

High-throughput

0.489

High

339620

ACSL3
Fatty acid CoA ligase Acsl3

1

2

High-throughput

0.489

High

351988

S1PR4
Sphingosine 1-phosphate receptor 4

1

2

High-throughput

0.489

High

572485

DRD2
D(2) dopamine receptor

1

3

High-throughput

0.489

High

630200

ACM3
Muscarinic acetylcholine receptor M3

1

2

High-throughput

0.489

High

638262

S1PR1
Sphingosine 1-phosphate receptor 1

1

2

High-throughput

0.489

High

638553

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.489

High

829596

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

1142218

P2RY6
P2Y purinoceptor 6

1

6

High-throughput

0.489

High

1257898

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

4

High-throughput

0.489

High

1291715

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1291921

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

4

High-throughput

0.489

High

1462497

GPR55
G-protein coupled receptor 55

1

7

High-throughput

0.489

High

1462499

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

173556

XPO1
Exportin-1

1

12

High-throughput

0.479

High

174641

TRI66
Tripartite motif-containing protein 66

1

3

High-throughput

0.479

High

247033

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

273731

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

9

High-throughput

0.479

High

316168

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

327665

ELP1
Elongator complex protein 1

1

1

High-throughput

0.479

High

332775

EPM2A
Laforin

1

1

High-throughput

0.479

High

364031

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

437390

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

508841

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

583027

EZRI
Ezrin

1

4

High-throughput

0.479

High

761932

HSP74
Heat shock 70 kDa protein 4

1

8

High-throughput

0.479

High

799578

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

861838

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.479

High

891361

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.479

High

896665

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

971294

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

976028

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.479

High

1017511

FOXK1
Forkhead box protein K1

1

8

High-throughput

0.479

High

1091378

FOXL1
Forkhead box protein L1

1

7

High-throughput

0.479

High

1110195

HDAC1
Histone deacetylase 1

1

8

High-throughput

0.479

High

1110893

IRF5
Interferon regulatory factor 5

1

4

High-throughput

0.479

High

1114665

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1115487

CUL4B
Cullin-4B

1

4

High-throughput

0.479

High

1116136

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.479

High

1123878

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.479

High

1135859

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1138758

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1156622

CCDC6
Coiled-coil domain-containing protein 6

1

5

High-throughput

0.479

High

1178467

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1197127

AMOT
Angiomotin

1

7

High-throughput

0.479

High

1220891

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.479

High

1258420

MOB3C
MOB kinase activator 3C

1

8

High-throughput

0.479

High

1280605

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1289723

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1324366

STK40
Serine/threonine-protein kinase 40

1

6

Small-scale

0.479

High

1337389

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.479

High

1367598

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1368976

GOGA1
Golgin subfamily A member 1

1

1

High-throughput

0.479

High

1385126

MOB3A
MOB kinase activator 3A

1

8

High-throughput

0.479

High

1399863

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1404700

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.479

High

1421229

CEP44
Centrosomal protein of 44 kDa

1

2

High-throughput

0.479

High

1435459

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1451314

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1459325

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1459832

TBK1
Serine/threonine-protein kinase TBK1

1

6

High-throughput

0.479

High

1460096

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

1461135

RCOR1
REST corepressor 1

1

3

High-throughput

0.479

High

1461979

MYO6
Unconventional myosin-VI

1

6

High-throughput

0.479

High

1462309

CC14A
Dual specificity protein phosphatase CDC14A

1

5

High-throughput

0.479

High

1462415

TTF2
Transcription termination factor 2

1

3

High-throughput

0.479

High

64153

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

897620

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.458

High

1110766

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1214604

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1295455

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.458

High

1436900

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1459887

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

1461378

AGO1
Protein argonaute-1

1

0

High-throughput

0.458

High

69844

ZN785
Zinc finger protein 785

1

3

High-throughput

0.445

High

140487

SDCB1
Syntenin-1

1

3

High-throughput

0.445

High

253178

MOT2
Monocarboxylate transporter 2

1

2

High-throughput

0.445

High

397228

ESR1
Estrogen receptor

1

17

High-throughput

0.445

High

553097

PIP
Prolactin-inducible protein

1

1

High-throughput

0.445

High

564567

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

839111

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

4

High-throughput

0.445

High

944101

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

13

High-throughput

0.445

High

1339352

BBS1
BBSome complex member BBS1

1

1

High-throughput

0.445

High

182209

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.437

High

218967

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

294532

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

412815

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

769522

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1241987

FBX42
F-box only protein 42

1

6

High-throughput

0.437

High

1249332

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1256111

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1381616

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

7

High-throughput

0.437

High

1384481

PF21A
PHD finger protein 21A

1

6

High-throughput

0.437

High

1395992

DNJC1
DnaJ homolog subfamily C member 1

1

7

High-throughput

0.437

High

1398238

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.437

High

1402159

RB40C
Ras-related protein Rab-40C

1

5

Small-scale

0.437

High

1431290

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.437

High

1433473

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

13

High-throughput

0.437

High

1434243

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1450507

DJC11
DnaJ homolog subfamily C member 11

1

5

High-throughput

0.437

High

1458657

KS6B2
Ribosomal protein S6 kinase beta-2

1

6

High-throughput

0.437

High

220637

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

296640

TNF13
Tumor necrosis factor ligand superfamily member 13

1

0

High-throughput

0.426

High

1326151

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1160

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

166451

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

2

High-throughput

0.407

High

406936

MAS
Proto-oncogene Mas

1

4

Small-scale

0.407

High

702870

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.407

High

845495

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.407

High

947485

RAB15
Ras-related protein Rab-15

1

1

High-throughput

0.407

High

1234037

S35E4
Solute carrier family 35 member E4

1

1

High-throughput

0.407

High

1239570

ZNT6
Zinc transporter 6

1

2

High-throughput

0.407

High

1240985

S27A4
Long-chain fatty acid transport protein 4

1

6

High-throughput

0.407

High

1309413

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.407

High

1355972

NET5
Netrin-5

1

2

High-throughput

0.407

High

1404974

S1PR3
Sphingosine 1-phosphate receptor 3

1

2

High-throughput

0.407

High

1448674

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

1

High-throughput

0.407

High

1449281

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

1326790

CBPA6
Carboxypeptidase A6

2

0

High-throughput

0.328

High

64398

CDHR4
Cadherin-related family member 4

1

0

High-throughput

0.279

Low

337843

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

469234

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.279

Low

936019

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

1127995

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.279

Low

1324516

FA43A
Protein FAM43A

1

0

High-throughput

0.279

Low

1340889

HUS1B
Checkpoint protein HUS1B

1

0

High-throughput

0.279

Low

1350918

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1363164

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.279

Low

1392022

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

1431011

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1461184

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

1462498

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.279

Low

880985

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

1324199

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1387242

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.249

Low

1392367

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

1380569

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025