HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: PKHA2 (Q9HB19)
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)
Gene: PLEKHA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19786618
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 425
+	Hs
		925632 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		PKHA1_HUMAN (1-425): 7.64e-108: 325: 44.21
+	Hs
		564691 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PKHA1_HUMAN (1-425): 7.64e-108: 325: 44.21
+	Hs
		309467 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		MTMR5_HUMAN (3-298): 4.14e-49: 181: 17.56
+	Hs
		309438 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		MTMR5_HUMAN (3-298): 4.14e-49: 181: 17.56
+	Hs
		309435 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		MTMR5_HUMAN (3-298): 4.14e-49: 181: 17.56
+	Hs
		309458 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		MTMR5_HUMAN (3-298): 4.14e-49: 181: 17.56
+	Hs
		925629 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		PKHA5_HUMAN (118-392): 3.97e-37: 146: 15.05
+	Hs
		564690 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		PKHA5_HUMAN (118-392): 3.97e-37: 146: 15.05
+	Hs
		925760 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		FARP1_HUMAN (27-311): 1.73e-35: 141: 15.46
+	Hs
		545625 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		PKHA5_HUMAN (118-392): 3.97e-37: 146: 15.05
+	Hs
		564756 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		FARP1_HUMAN (27-311): 1.73e-35: 141: 15.46
+	Hs
		545718 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		FARP1_HUMAN (27-311): 1.73e-35: 141: 15.46
+	Hs
		892603 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		PKHA5_HUMAN (118-392): 3.97e-37: 146: 15.05
+	Hs
		925705 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		SWP70_HUMAN (199-400): 2.58e-32: 130: 18.40
+	Hs
		925612 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DEFI6_HUMAN (199-301): 7.83e-32: 129: 27.18
+	Hs
		545684 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		SWP70_HUMAN (199-400): 2.58e-32: 130: 18.40
+	Hs
		545615 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DEFI6_HUMAN (199-301): 7.83e-32: 129: 27.18
+	Hs
		892513 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ARAP3_HUMAN (90-301): 2.11e-33: 135: 17.37
+	Hs
		925478 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		ARAP2_HUMAN (185-326): 3.94e-12: 70.4: 18.18
+	Hs
		892516 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		ARAP2_HUMAN (185-326): 3.94e-12: 70.4: 18.18