HitPredict

Interactor 1: ERF3A (P15170)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)
Gene: GSPT1

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	26172506, 12865429
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 497
+	Hs
		545849 ERF3A_HUMAN (1-499): 0: 567: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		545848 ERF3A_HUMAN (1-499): 0: 567: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		932681 EF1A1_HUMAN (70-498): 1.24e-175: 503: 38.29		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		984430 EF1A2_HUMAN (70-498): 6.64e-174: 499: 37.16		RNF26_HUMAN (320-496): 6.59e-25: 108: 14.13
+	Dm
		399186 EF1A2_DROME (70-494): 4.72e-173: 496: 37.73		DIAP2_DROME (14-98): 7.09e-22: 100: 34.12
+	Dm
		444575 EF1A1_DROME (70-499): 3.29e-172: 495: 38.88		DIAP2_DROME (14-98): 7.09e-22: 100: 34.12