Protein: TYSD1
Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form]

Gene: TYSD1, TYSND1
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q2T9J0

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004252 - serine-type endopeptidase activity
GO:0005777 - peroxisome
GO:0005782 - peroxisomal matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1179757

TYSD1
Peroxisomal leader peptide-processing protease

1

13

Small-scale

0.757

High

1179768

JOS2
Josephin-2

4

1

High-throughput

0.694

High

537254

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

1179775

CHIP
E3 ubiquitin-protein ligase CHIP

2

1

High-throughput

0.628

High

896246

PEX5
Peroxisomal targeting signal 1 receptor

2

1

Small-scale

0.584

High

399978

CATA
Catalase

2

0

High-throughput

0.563

High

1141451

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

Small-scale

0.550

High

634762

GRAH
Granzyme H

1

0

High-throughput

0.513

High

508063

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

830838

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

1179763

VP37D
Vacuolar protein sorting-associated protein 37D

1

1

High-throughput

0.489

High

450308

TY3H
Tyrosine 3-monooxygenase

1

0

Small-scale

0.480

High

172876

XPO1
Exportin-1

1

1

High-throughput

0.479

High

520099

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

1107778

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1179773

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

122503

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.458

High

1128731

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1179769

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.458

High

647441

SCP2
Sterol carrier protein 2

1

2

Small-scale

0.445

High

1060356

SLC31
Amino acid transporter heavy chain SLC3A1

1

3

High-throughput

0.445

High

1179761

Q7Z7N5
Josephin-2

1

1

High-throughput

0.445

High

1179762

LONP2
Lon protease homolog 2, peroxisomal

1

5

Small-scale

0.445

High

1179759

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1179770

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

284577

ECI2
Enoyl-CoA delta isomerase 2

1

0

Small-scale

0.426

High

906416

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

Small-scale

0.426

High

1179760

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.426

High

1179765

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.426

High

1179771

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.426

High

1179758

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.328

High

1179772

TEKT3
Tektin-3

2

0

High-throughput

0.328

High

1179766

ARG39
Rho guanine nucleotide exchange factor 39

1

0

High-throughput

0.279

Low

1179767

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1179774

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

653347

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

868297

P2RY1
P2Y purinoceptor 1

1

0

High-throughput

0.232

Low

1179764

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025