HitPredict

Interactor 1: ATF2 (P15336)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
Gene: ATF2

Interactor 2: MK14 (Q16539)
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
Gene: MAPK14

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 17170118, 26391660, 18695677, 16998585, 10978313, 9753474, 26987986, 25098452, 9596579, 12118074, 10581258, 11532856, 7535770, 16945434, 11279118, 27142525, 21444723, 16456540, 9162092, 10708586 and 11 others

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Identification Methods enzymatic study, affinity chromatography technology, pull down, protein kinase assay, in-gel kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0010628 - positive regulation of gene expression
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 505
Hs

1 360
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Last updated: 15 Jul 2024