HitPredict - High confidence protein-protein interactions

Interactor 1: KCNE1 (P15382)
Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)
Gene: KCNE1

Interactor 2: KCNQ1 (P51787)
Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
Gene: KCNQ1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	24713462, 11101505, 19114714, 19521339
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	ISK_Channel~Ion_trans
Common GO terms	GO:0005251 - delayed rectifier potassium channel activity GO:0005764 - lysosome GO:0005886 - plasma membrane GO:0007605 - sensory perception of sound GO:0008076 - voltage-gated potassium channel complex and 15 others more... GO:0016324 - apical plasma membrane GO:0044325 - transmembrane transporter binding GO:0045121 - membrane raft GO:0060307 - regulation of ventricular cardiac muscle cell membrane repolarization GO:0071320 - cellular response to cAMP GO:0071805 - potassium ion transmembrane transport GO:0086005 - ventricular cardiac muscle cell action potential GO:0086011 - membrane repolarization during action potential GO:0086013 - membrane repolarization during cardiac muscle cell action potential GO:0086091 - regulation of heart rate by cardiac conduction GO:0097623 - potassium ion export across plasma membrane GO:0098915 - membrane repolarization during ventricular cardiac muscle cell action potential GO:1901381 - positive regulation of potassium ion transmembrane transport GO:1902260 - negative regulation of delayed rectifier potassium channel activity GO:1902282 - voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	129
Hs

1	676

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Last updated: 15 Jul 2024