Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1
Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.972 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 8647120, 15558030, 29997244, 8900182, 32203420, 7809090, 10207103, 9013873, 18692475 |
| Identification Methods | pull down, fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~SH2, PH~SH3_1, RhoGEF~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1 |
| Common GO terms | GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
