HitPredict

Interactor 1: ZEP1 (P15822)
Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)
Gene: HIVEP1

Interactor 2: LHX2 (P50458)
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)
Gene: LHX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2718 Hs			1 406
+	Hs
		550340 ZEP1_HUMAN (2-2718): 0: 801: 100.00		LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63
+	Hs
		550446 ZEP1_HUMAN (2-2718): 0: 801: 100.00		LHX6_HUMAN (111-368): 2.79e-21: 96.4: 21.32
+	Hs
		550422 ZEP1_HUMAN (2-2718): 0: 801: 100.00		LHX4_HUMAN (34-107): 2.07e-11: 67.1: 23.68
+	Hs
		550441 ZEP1_HUMAN (2-2718): 0: 801: 100.00		LHX3_HUMAN (27-113): 1e-09: 61.7: 22.47
+	Ce
		589696 SMA9_CAEEL (401-517): 2.85e-21: 105: 30.25		LIN11_CAEEL (10-395): 6.31e-49: 172: 25.06
+	Ce
		447562 SMA9_CAEEL (401-517): 2.85e-21: 105: 30.25		MEC3_CAEEL (45-325): 2.4e-43: 155: 25.18
+	Hs
		638487 ZNF84_HUMAN (684-1016): 3.15e-26: 119: 7.72		RBTN1_HUMAN (33-171): 5.63e-40: 141: 41.84
+	Hs
		638500 ZN177_HUMAN (1996-2157): 1.8e-22: 106: 15.43		RBTN1_HUMAN (33-171): 5.63e-40: 141: 41.84
+	Hs
		903710 IKZF1_HUMAN (2001-2144): 1.33e-11: 71.9: 28.77		LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58
+	Hs
		903791 IKZF3_HUMAN (358-457): 1.52e-11: 71.9: 35.00		LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58
+	Hs
		196621 ZBT24_HUMAN (2008-2475): 6.03e-14: 79.9: 15.43		LHX8_HUMAN (115-394): 4.48e-35: 134: 23.84
+	Hs
		638501 IKZF1_HUMAN (2001-2144): 1.33e-11: 71.9: 28.77		RBTN1_HUMAN (33-171): 5.63e-40: 141: 41.84
+	Hs
		638592 IKZF3_HUMAN (358-457): 1.52e-11: 71.9: 35.00		RBTN1_HUMAN (33-171): 5.63e-40: 141: 41.84
+	Dm
		114756 Q8MRU2_DROME (241-471): 5.49e-12: 73.3: 13.98		M9PD53_DROME (111-346): 8.42e-29: 120: 21.19
+	Dm
		112556 Q9VM37_DROME (381-551): 2.98e-11: 71.1: 22.65		M9NCY1_DROME (111-346): 8.93e-29: 118: 21.19
+	Hs
		846679 ZNF84_HUMAN (684-1016): 3.15e-26: 119: 7.72		LMO3_HUMAN (53-108): 5.21e-10: 59.2: 28.07
+	Hs
		1033698 IKZF1_HUMAN (2001-2144): 1.33e-11: 71.9: 28.77		LHX4_HUMAN (34-107): 2.07e-11: 67.1: 23.68
+	Hs
		1033682 IKZF1_HUMAN (2001-2144): 1.33e-11: 71.9: 28.77		LMO3_HUMAN (53-108): 5.21e-10: 59.2: 28.07