HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	12354094, 20940144, 22606318, 20613874, 23708667, 26496610, 30301766, 10888872, 9302295, 24958773
Identification Methods	pull down, affinity chromatography technology, unspecified method
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005657 - replication fork
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 1616
+	Hs
		551081 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		Q59FP7_HUMAN (14-1616): 0: 1691: 99.75
+	Mm
		568876 PCNA_MOUSE (1-261): 1.26e-125: 358: 96.94		DNMT1_MOUSE (1-1597): 0: 1607: 77.33
+	Xl
		1009585 Q9I893_XENLA (1-261): 1.34e-122: 351: 90.04		P79922_XENLA (126-1616): 0: 1498: 70.07
+	Hs
		551102 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14