Protein: DNMT1
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (Met-1) (EC 2.1.1.37) (DNA methyltransferase MmuI) (DNA MTase MmuI) (M.MmuI) (MCMT)

Gene: DNMT1
Organism: Mus musculus
Interactions: 37
UniProt ID: P13864

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000792 - heterochromatin
GO:0001674 - female germ cell nucleus
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568899

UHRF1
E3 ubiquitin-protein ligase UHRF1

6

12

Small-scale

0.941

High

508949

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

8

High-throughput

0.647

High

568874

DNMT1
DNA

1

12

Small-scale

0.618

High

568891

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.618

High

568887

EZH2
Histone-lysine N-methyltransferase EZH2

2

19

Small-scale

0.601

High

568883

TF65
Transcription factor p65

1

5

High-throughput

0.541

High

568895

TOX3
TOX high mobility group box family member 3

1

15

High-throughput

0.541

High

568892

HDAC4
Histone deacetylase 4

1

18

High-throughput

0.536

High

568890

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

12

Small-scale

0.527

High

148641

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.515

High

568902

BRAP
BRCA1-associated protein

1

2

Small-scale

0.515

High

568875

TFE2
Transcription factor E2-alpha

1

1

High-throughput

0.479

High

568876

PCNA
Proliferating cell nuclear antigen

1

5

Small-scale

0.479

High

568878

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.479

High

568879

STAT6
Signal transducer and transcription activator 6

1

1

Small-scale

0.479

High

568881

ATX1
Ataxin-1

1

2

High-throughput

0.479

High

568882

MSH6
DNA mismatch repair protein Msh6

1

4

Small-scale

0.479

High

568885

DDB1
DNA damage-binding protein 1

1

4

Small-scale

0.479

High

568886

Q3UQ17
Zinc finger and BTB domain containing 16

1

2

Small-scale

0.479

High

568888

HESX1
Homeobox expressed in ES cells 1

1

1

Small-scale

0.479

High

568889

ATM
Serine-protein kinase ATM

1

9

Small-scale

0.479

High

568894

FACD2
Fanconi anemia group D2 protein homolog

1

6

High-throughput

0.479

High

568896

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.479

High

568897

MT21E
Protein-lysine methyltransferase METTL21E

1

2

High-throughput

0.479

High

568898

KAT5
Histone acetyltransferase KAT5

1

2

Small-scale

0.479

High

568900

EED
Polycomb protein EED

1

12

High-throughput

0.479

High

568901

Q921K2
Poly [ADP-ribose] polymerase

1

7

Small-scale

0.479

High

568903

PAF15
PCNA-associated factor

1

2

High-throughput

0.479

High

568904

DMAP1
DNA methyltransferase 1-associated protein 1

1

1

Small-scale

0.479

High

568905

CUL3
Cullin-3

1

11

Small-scale

0.479

High

568906

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

14

Small-scale

0.479

High

486803

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

568877

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.445

High

568884

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.445

High

568893

SUZ12
Polycomb protein Suz12

1

3

Small-scale

0.445

High

568880

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025