HitPredict

Interactor 1: RFA2 (P15927)
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
Gene: RPA2

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 25499885, 26496610, 26474068, 20679368, 8663296, 27723720, 24126761, 10064605, 24981860, 11927569, 8663111, 28854355, 37827155, 21504906, 26186194, 28514442, 28575657, 30279242, 32296183, 33961781 and 10 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, x-ray crystallography, proximity labelling technology, biochemical, cosedimentation through density gradient, coimmunoprecipitation, fluorescence microscopy, molecular sieving and 7 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0003684 - damaged DNA binding
GO:0003697 - single-stranded DNA binding
and 11 others

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Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 270
Hs

1 616
+ Hs
+ Os
+ At
+ At
+ Dm
+ Sc
+ Ca
+ Ce
+ Os

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024