HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30110629
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HAT_KAT11~Histone
Common GO terms	GO:0003677 - DNA binding GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 2414
+	Hs
		998866 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		391671 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		998781 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		70932 H2A3_MOUSE (1-129): 5.88e-66: 197: 91.47		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Hs
		555661 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		391923 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		555299 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		555470 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		631492 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		1067038 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		391554 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		1067005 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		555434 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86
+	Hs
		554260 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Hs
		555463 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		555528 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		391802 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13
+	Hs
		391768 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		391823 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Mm
		101453 H2A3_MOUSE (1-129): 5.88e-66: 197: 91.47		F8VPR5_MOUSE (1752-2401): 7.8e-10: 67.1: 12.31