HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	35384245, 17452978, 26839216
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 724
+	Hs
		129191 PGFRA_HUMAN (1-1089): 0: 817: 100.00		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		452361 PGFRB_HUMAN (29-1089): 0: 650: 43.33		P85A_HUMAN (1-724): 0: 596: 100.00
+	Mm
		403533 KIT_MOUSE (18-994): 0: 571: 33.43		P85A_MOUSE (1-724): 0: 592: 95.99
+	Hs
		499235 KIT_HUMAN (18-978): 0: 559: 33.64		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		557215 PGFRA_HUMAN (1-1089): 0: 817: 100.00		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		129176 PGFRB_HUMAN (29-1089): 0: 650: 43.33		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		655242 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129178 KIT_HUMAN (18-978): 0: 559: 33.64		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		499280 KIT_HUMAN (18-978): 0: 559: 33.64		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		609182 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		572588 VGFR1_HUMAN (18-659): 1.85e-51: 200: 18.22		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		433221 PGFRB_HUMAN (29-1089): 0: 650: 43.33		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Hs
		433226 KIT_HUMAN (18-978): 0: 559: 33.64		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Mm
		140055 KIT_MOUSE (18-994): 0: 571: 33.43		P85B_MOUSE (287-439): 8.37e-12: 70.8: 23.38
+	Mm
		403538 KIT_MOUSE (18-994): 0: 571: 33.43		MATK_MOUSE (617-721): 2.52e-11: 68.7: 24.53
+	Hs
		433274 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Ce
		106190 EGL15_CAEEL (5-1072): 3.56e-155: 490: 16.61		G5EDP9_CAEEL (607-722): 6.5e-17: 86.4: 27.97
+	Mm
		546314 NTRK2_MOUSE (53-776): 3.36e-53: 202: 13.62		RHG32_MOUSE (14-612): 1.58e-61: 226: 14.33
+	Hs
		64712 NTRK2_HUMAN (48-776): 2.93e-51: 197: 14.04		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		433247 VGFR1_HUMAN (18-659): 1.85e-51: 200: 18.22		YES_HUMAN (568-724): 2.15e-31: 131: 20.61