Protein: HRK1
Serine/threonine-protein kinase HRK1 (EC 2.7.11.1) (Hygromycin resistance kinase 1)

Gene: HRK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 93
UniProt ID: Q08732

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006873 - intracellular monoatomic ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

448820

SNF1
Carbon catabolite-derepressing protein kinase

1

19

High-throughput

0.691

High

597570

EF3A
Elongation factor 3A

1

4

High-throughput

0.691

High

623029

CSK22
Casein kinase II subunit alpha'

1

19

High-throughput

0.691

High

851027

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.691

High

1031068

NOP3
Serine/arginine

1

7

High-throughput

0.691

High

557041

AAKG
5'-AMP-activated protein kinase subunit gamma

3

9

High-throughput

0.662

High

694175

CDC15
Cell division control protein 15

1

18

High-throughput

0.647

High

1064750

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

1

High-throughput

0.647

High

525410

HSP71
Heat shock protein SSA1

3

17

High-throughput

0.633

High

633516

PP11
Serine/threonine-protein phosphatase PP1-1

2

11

High-throughput

0.621

High

807167

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

5

High-throughput

0.618

High

1054261

FKBP4
FK506-binding protein 4

1

5

High-throughput

0.618

High

1064752

YRA1
RNA annealing protein YRA1

1

5

High-throughput

0.618

High

393469

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.618

High

741163

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

4

High-throughput

0.618

High

1046158

GIS4
Protein GIS4

2

1

High-throughput

0.611

High

849560

GCN20
Protein GCN20

1

2

High-throughput

0.575

High

1044162

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.553

High

1038785

SKI8
Antiviral protein SKI8

1

3

High-throughput

0.541

High

637296

PWP1
Periodic tryptophan protein 1

1

4

High-throughput

0.536

High

722329

XPO1
Exportin-1

1

6

High-throughput

0.536

High

746686

DRS1
ATP-dependent RNA helicase DRS1

1

7

High-throughput

0.536

High

750163

MRT4
Ribosome assembly factor MRT4

1

3

High-throughput

0.536

High

751503

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.536

High

923141

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

1027377

REG1
Resistance to glucose repression protein 1

1

1

High-throughput

0.536

High

1039648

NOG1
Nucleolar GTP-binding protein 1

1

2

High-throughput

0.536

High

1043305

HAS1
ATP-dependent RNA helicase HAS1

1

8

High-throughput

0.536

High

1064748

CUB1

1

1

High-throughput

0.536

High

671206

SIS1
Protein SIS1

1

5

High-throughput

0.514

High

1064754

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

446254

PHSG
Glycogen phosphorylase

1

1

High-throughput

0.501

High

455593

SYSC
Serine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

590742

HSP26
Heat shock protein 26

1

1

High-throughput

0.501

High

815961

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

8

High-throughput

0.501

High

1046734

ASND1
Asparagine synthetase domain-containing protein YML096W

1

1

High-throughput

0.501

High

585400

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.489

High

740763

SRP40
Suppressor protein SRP40

1

1

High-throughput

0.489

High

782475

RPF2
Ribosome biogenesis protein RPF2

1

2

High-throughput

0.489

High

803959

CIC1
Proteasome-interacting protein CIC1

1

1

High-throughput

0.489

High

827628

RLP7
Ribosome biogenesis protein RLP7

1

3

High-throughput

0.489

High

828516

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.489

High

830202

NOP2
25S rRNA

1

1

High-throughput

0.489

High

893349

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

5

High-throughput

0.489

High

1047296

ERB1
Ribosome biogenesis protein ERB1

1

4

High-throughput

0.489

High

1060743

NOC3
Nucleolar complex-associated protein 3

1

1

High-throughput

0.489

High

1064747

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.489

High

510875

HSP77
Import motor subunit, mitochondrial

1

14

High-throughput

0.479

High

558888

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

748085

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

785989

LONM
Lon protease homolog, mitochondrial

1

7

High-throughput

0.479

High

1064753

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

850031

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.458

High

924447

IGO1
mRNA stability protein IGO1

1

0

Small-scale

0.458

High

919712

REXO1
RNA exonuclease 1

1

1

High-throughput

0.457

High

922163

ARE2
Sterol O-acyltransferase 2

1

1

High-throughput

0.457

High

1064751

SAS10
Something about silencing protein 10

1

1

High-throughput

0.457

High

394973

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

427468

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.445

High

453835

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.445

High

527901

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

546584

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

592549

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.445

High

802118

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.445

High

824575

6P21
6-phosphofructo-2-kinase 1

1

8

High-throughput

0.445

High

836936

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

402141

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.437

High

708417

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.437

High

779363

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.437

High

812728

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

826902

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.437

High

919029

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

1064749

YTM1
Ribosome biogenesis protein YTM1

1

7

High-throughput

0.437

High

575533

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.407

High

858084

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

534157

MAK16
Protein MAK16

1

0

High-throughput

0.279

Low

676681

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.279

Low

677253

SPB1
27S pre-rRNA

1

0

High-throughput

0.279

Low

763133

RRP1
Ribosomal RNA-processing protein 1

1

0

High-throughput

0.279

Low

780337

EBP2
rRNA-processing protein EBP2

1

0

High-throughput

0.279

Low

805106

RPF1
Ribosome production factor 1

1

0

High-throughput

0.279

Low

814408

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.279

Low

816923

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.279

Low

917576

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.279

Low

1055478

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.279

Low

600720

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.261

Low

744721

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

0

High-throughput

0.261

Low

796685

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.261

Low

814131

HPH2
Protein HPH2

1

0

High-throughput

0.261

Low

917999

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.261

Low

794935

YBI6
Uncharacterized protein YBL086C

1

0

High-throughput

0.249

Low

795250

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

818289

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025