Protein: NPR1
Nitrogen permease reactivator protein (EC 2.7.11.1) (Serine/threonine-protein kinase NPR1)

Gene: NPR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 94
UniProt ID: P22211

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

646158

GAL83
SNF1 protein kinase subunit beta-3

3

17

High-throughput

0.853

High

448643

SNF1
Carbon catabolite-derepressing protein kinase

2

19

High-throughput

0.789

High

646106

NPR1
Nitrogen permease reactivator protein

2

19

Small-scale

0.778

High

578863

HSC82
ATP-dependent molecular chaperone HSC82

2

20

High-throughput

0.767

High

584343

GCN2
eIF-2-alpha kinase GCN2

1

20

High-throughput

0.691

High

646112

HRR25
Casein kinase I homolog HRR25

1

17

High-throughput

0.691

High

517896

SSBP1
Single-stranded nucleic acid-binding protein

1

11

High-throughput

0.647

High

646140

YAR1
Ankyrin repeat-containing protein YAR1

1

8

High-throughput

0.647

High

646147

RHO5
GTP-binding protein RHO5

1

4

Small-scale

0.647

High

523080

HSP71
Heat shock protein SSA1

3

20

High-throughput

0.633

High

567713

MSI1
Histone-binding protein MSI1

2

4

Small-scale

0.619

High

646170

PAR32
Protein PAR32

2

1

High-throughput

0.619

High

646124

KSP1
Serine/threonine-protein kinase KSP1

1

20

High-throughput

0.618

High

556987

AAKG
5'-AMP-activated protein kinase subunit gamma

2

14

High-throughput

0.611

High

439242

PDC1
Pyruvate decarboxylase isozyme 1

2

4

High-throughput

0.584

High

646138

GCN20
Protein GCN20

1

4

High-throughput

0.575

High

646150

ACT
Actin

1

3

High-throughput

0.575

High

646126

RPN1
26S proteasome regulatory subunit RPN1

2

9

High-throughput

0.571

High

646107

CANB
Calcineurin subunit B

1

20

High-throughput

0.553

High

543837

SSB1
Ribosome-associated molecular chaperone SSB1

2

20

High-throughput

0.552

High

646117

TOR2
Serine/threonine-protein kinase TOR2

1

13

High-throughput

0.536

High

646122

TOR1
Serine/threonine-protein kinase TOR1

1

11

High-throughput

0.536

High

646128

KOG1
Target of rapamycin complex 1 subunit KOG1

1

10

High-throughput

0.536

High

646130

RSP5
E3 ubiquitin-protein ligase RSP5

1

9

High-throughput

0.536

High

646136

LST8
Target of rapamycin complex subunit LST8

1

11

High-throughput

0.536

High

646143

BUL1
Ubiquitin ligase-binding protein BUL1

1

1

High-throughput

0.536

High

646157

GIS4
Protein GIS4

1

2

High-throughput

0.536

High

646160

DYN3
Cytoplasmic dynein intermediate light chain DYN3

1

0

High-throughput

0.518

High

646116

RPN2
26S proteasome regulatory subunit RPN2

1

9

High-throughput

0.514

High

449397

SPT2
Protein SPT2

1

0

High-throughput

0.513

High

646165

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.513

High

416196

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

609205

CLC1
Clathrin light chain

1

1

High-throughput

0.501

High

646109

CDC48
Cell division control protein 48

1

10

High-throughput

0.501

High

646119

KPR1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.501

High

646131

SYPM
Probable proline--tRNA ligase, mitochondrial

1

8

High-throughput

0.501

High

646148

TBCB
Tubulin-specific chaperone B

1

4

High-throughput

0.501

High

646154

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

1

High-throughput

0.501

High

646168

RIB2
Bifunctional protein RIB2 [Includes: tRNA pseudouridine(32) synthase, cytoplasmic

1

1

High-throughput

0.501

High

405030

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.500

High

555007

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.500

High

646127

ARO9
Aromatic amino acid aminotransferase 2

1

2

High-throughput

0.500

High

646162

YL257
Uncharacterized protein YLR257W

1

0

High-throughput

0.480

High

646169

LDB19
Protein LDB19

1

0

Small-scale

0.480

High

510204

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.479

High

646113

BMH1
Protein BMH1

1

16

High-throughput

0.479

High

646120

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

646139

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

11

High-throughput

0.479

High

646142

ALY2
Arrestin-related trafficking adapter 3

1

7

Small-scale

0.479

High

646151

REG1
Resistance to glucose repression protein 1

1

2

High-throughput

0.479

High

646156

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

646164

LAM6
Membrane-anchored lipid-binding protein LAM6

1

2

Small-scale

0.479

High

646167

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

646141

FYV8
Protein FYV8

1

0

High-throughput

0.458

High

646144

PNC1
Nicotinamidase

1

0

High-throughput

0.458

High

646145

PIB2
Glutamine sensor PIB2

1

1

High-throughput

0.457

High

646146

ORM1
Protein ORM1

1

2

Small-scale

0.457

High

646153

CTF4
DNA polymerase alpha-binding protein

1

7

High-throughput

0.457

High

646155

YP077
Uncharacterized protein YPL077C

1

1

High-throughput

0.457

High

646161

ORM2
Protein ORM2

1

2

Small-scale

0.457

High

646166

ATG9
Autophagy-related protein 9

1

1

Small-scale

0.457

High

366932

ATPB
ATP synthase subunit beta, mitochondrial

1

11

High-throughput

0.445

High

386568

TBB
Tubulin beta chain

1

8

High-throughput

0.445

High

394243

EF1A
Elongation factor 1-alpha

1

8

High-throughput

0.445

High

434835

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.445

High

453424

PYR1
Multifunctional protein URA2

1

11

High-throughput

0.445

High

455477

PMM
Phosphomannomutase

1

3

High-throughput

0.445

High

486033

TBA1
Tubulin alpha-1 chain

1

8

High-throughput

0.445

High

525940

HSP72
Heat shock protein SSA2

1

20

High-throughput

0.445

High

531247

METK1
S-adenosylmethionine synthase 1

1

5

High-throughput

0.445

High

598810

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

15

High-throughput

0.445

High

598954

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

15

High-throughput

0.445

High

603409

VATA
V-type proton ATPase catalytic subunit A

1

16

High-throughput

0.445

High

646110

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.445

High

646114

EF2
Elongation factor 2

1

10

High-throughput

0.445

High

646118

BRR2
Pre-mRNA-splicing helicase BRR2

1

7

High-throughput

0.445

High

646121

GCN1
eIF-2-alpha kinase activator GCN1

1

16

High-throughput

0.445

High

646123

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.445

High

646125

YHI0
Putative proline--tRNA ligase YHR020W

1

7

High-throughput

0.445

High

646132

IMB4
Importin subunit beta-4

1

4

High-throughput

0.445

High

646133

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

646134

6P21
6-phosphofructo-2-kinase 1

1

10

High-throughput

0.445

High

646137

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.445

High

646149

DNM1
Dynamin-related protein DNM1

1

3

High-throughput

0.445

High

646152

ACAC
Acetyl-CoA carboxylase

1

11

High-throughput

0.445

High

646111

TF2B
Transcription initiation factor IIB

1

14

High-throughput

0.437

High

646135

DSN1
Kinetochore-associated protein DSN1

1

5

High-throughput

0.437

High

646163

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

646129

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

575383

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.407

High

646108

ILV6
Acetolactate synthase small subunit, mitochondrial

1

1

High-throughput

0.407

High

646115

ERG1
Squalene epoxidase ERG1

1

1

High-throughput

0.407

High

646159

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025