HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: PE2R4 (P35408)
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Gene: PTGER4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	23242524, 16432186
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 488
+	Hs
		557160 SRC_HUMAN (1-536): 0: 644: 100.00		PE2R2_HUMAN (20-370): 1.17e-79: 253: 30.96
+	Hs
		458258 SRC_HUMAN (1-536): 0: 644: 100.00		ADRB2_HUMAN (13-352): 3.19e-78: 251: 16.77
+	Mm
		431337 SRC_MOUSE (1-536): 0: 643: 98.51		5HT4R_MOUSE (5-372): 1.64e-72: 236: 18.37
+	Hs
		557057 SRC_HUMAN (1-536): 0: 644: 100.00		ADRB3_HUMAN (3-340): 8.27e-68: 224: 21.93
+	Rn
		753862 SRC_RAT (1-536): 0: 636: 98.14		OPRM_RAT (6-386): 1.94e-65: 218: 14.62
+	Hs
		440446 FYN_HUMAN (1-536): 0: 586: 68.39		5HT6R_HUMAN (2-377): 3.62e-69: 229: 16.71
+	Hs
		463352 LYN_HUMAN (1-531): 0: 522: 52.82		5HT2A_HUMAN (1-403): 5.89e-74: 242: 16.91