Protein: SAE1
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]

Gene: SAE1
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q9UBE0

Gene Ontology (top 5):
GO:0004839 - ubiquitin activating enzyme activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0008047 - enzyme activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1353967

SAE2
SUMO-activating enzyme subunit 2

17

12

Small-scale

0.987

High

930427

UBC9
SUMO-conjugating enzyme UBC9

10

20

Small-scale

0.980

High

902786

SUMO2
Small ubiquitin-related modifier 2

4

10

Small-scale

0.886

High

928216

SUMO1
Small ubiquitin-related modifier 1

2

10

Small-scale

0.799

High

879159

SUMO3
Small ubiquitin-related modifier 3

2

10

High-throughput

0.776

High

228953

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.754

High

171506

UBD
Ubiquitin D

1

13

Small-scale

0.647

High

896245

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.618

High

909266

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1353970

UBQL2
Ubiquilin-2

1

2

High-throughput

0.618

High

197846

CRX
Cone-rod homeobox protein

2

1

High-throughput

0.606

High

641586

PAX6
Paired box protein Pax-6

2

2

High-throughput

0.606

High

971682

PAX5
Paired box protein Pax-5

2

2

High-throughput

0.606

High

988815

PAX8
Paired box protein Pax-8

2

2

High-throughput

0.606

High

1047549

NFYC
Nuclear transcription factor Y subunit gamma

2

0

High-throughput

0.580

High

272749

OFD1
Centriole and centriolar satellite protein OFD1

2

1

High-throughput

0.571

High

1130686

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

674889

AGTR1
Type-1 angiotensin II receptor

1

1

High-throughput

0.541

High

983685

FAK1
Focal adhesion kinase 1

1

3

High-throughput

0.541

High

128660

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

131523

IMA4
Importin subunit alpha-4

1

2

High-throughput

0.536

High

336611

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

529842

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

853502

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.536

High

863751

CATC
Dipeptidyl peptidase 1

1

2

High-throughput

0.536

High

1353973

TRI35
E3 ubiquitin-protein ligase TRIM35

1

2

High-throughput

0.536

High

972601

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

2

High-throughput

0.515

High

1151279

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

241912

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.513

High

781474

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

873881

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

1039348

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.513

High

1060951

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

1307549

GDF15
Growth/differentiation factor 15

1

0

High-throughput

0.513

High

1314636

RBM4
RNA-binding protein 4

1

0

High-throughput

0.513

High

1334768

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.513

High

1353971

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

387652

P53
Cellular tumor antigen p53

1

1

Small-scale

0.501

High

395971

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

871812

HSP72
Heat shock-related 70 kDa protein 2

1

2

Small-scale

0.501

High

976522

ERCC6
DNA excision repair protein ERCC-6

1

1

High-throughput

0.501

High

1121211

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

2

Small-scale

0.501

High

434505

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.493

High

657446

ABCD3
ATP-binding cassette sub-family D member 3

1

2

High-throughput

0.489

High

1336177

CPNE5
Copine-5

1

1

High-throughput

0.489

High

838328

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

794572

ETV4
ETS translocation variant 4

1

0

Small-scale

0.480

High

241655

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

245048

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

262199

TRIM3
Tripartite motif-containing protein 3

1

5

Small-scale

0.479

High

324658

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

348130

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

375028

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

553955

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

570141

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

652493

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

721674

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

727074

FUS
RNA-binding protein FUS

1

2

High-throughput

0.479

High

880841

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

918748

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

967486

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

983260

UBE3A
Ubiquitin-protein ligase E3A

1

10

High-throughput

0.479

High

1029971

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.479

High

1050288

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1076797

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.479

High

1080432

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1172093

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1267211

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1281445

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1331522

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1332720

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1353969

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1353972

HERC5
E3 ISG15--protein ligase HERC5

1

9

Small-scale

0.479

High

1353974

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.479

High

726452

BASI
Basigin

1

2

High-throughput

0.470

High

610088

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.458

High

790690

WASP
Actin nucleation-promoting factor WAS

1

0

Small-scale

0.458

High

824488

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

897848

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

910119

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

959742

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1081428

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1116780

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.458

High

1262535

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

0

High-throughput

0.458

High

1327136

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1353968

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

497721

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

906181

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

Small-scale

0.445

High

385653

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

1318315

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

Small-scale

0.437

High

1335368

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.437

High

1203587

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.426

High

831757

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

645929

IL3RA
Interleukin-3 receptor subunit alpha

1

0

High-throughput

0.282

High

176872

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.279

Low

1287211

FAF2
FAS-associated factor 2

1

0

High-throughput

0.279

Low

1315293

C1QT2
Complement C1q tumor necrosis factor-related protein 2

1

0

High-throughput

0.279

Low

1086143

CP1B1
Cytochrome P450 1B1

1

0

High-throughput

0.269

Low

155463

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

456955

FURIN
Furin

1

0

High-throughput

0.249

Low

1316791

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1350256

UNC79
Protein unc-79 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024