Protein: 5HT6R
5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)

Gene: 5HT6R, HTR6
Organism: Homo sapiens
Interactions: 54
UniProt ID: P50406

Gene Ontology (top 5):
GO:0004969 - histamine receptor activity
GO:0004993 - G protein-coupled serotonin receptor activity
GO:0005886 - plasma membrane
GO:0005929 - cilium
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

637864

NF1
Neurofibromin

2

2

Small-scale

0.624

High

895202

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.618

High

895220

ATX10
Ataxin-10

2

0

Small-scale

0.588

High

895196

CDK5
Cyclin-dependent kinase 5

1

0

Small-scale

0.586

High

440446

FYN
Tyrosine-protein kinase Fyn

1

4

Small-scale

0.586

High

861066

MAP1B
Microtubule-associated protein 1B

1

4

Small-scale

0.586

High

720384

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

1

High-throughput

0.541

High

807319

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.541

High

895195

ACTB
Actin, cytoplasmic 1

1

7

High-throughput

0.541

High

895206

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.541

High

895216

ABCA2
ATP-binding cassette sub-family A member 2

1

2

High-throughput

0.541

High

895218

TTYH1
Protein tweety homolog 1

1

3

High-throughput

0.541

High

895194

NOVA1
RNA-binding protein Nova-1

1

4

Small-scale

0.535

High

895204

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.535

High

136167

SYT5
Synaptotagmin-5

1

0

High-throughput

0.518

High

406966

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.518

High

572711

AK1A1
Aldo-keto reductase family 1 member A1

1

0

High-throughput

0.518

High

895223

TMM98
Transmembrane protein 98

1

0

High-throughput

0.518

High

124752

AIP
AH receptor-interacting protein

1

1

High-throughput

0.494

High

586975

CHIN
N-chimaerin

1

4

High-throughput

0.494

High

895201

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.494

High

895210

DHRS1
Dehydrogenase/reductase SDR family member 1

1

1

High-throughput

0.494

High

895226

AP4S1
AP-4 complex subunit sigma-1

1

1

High-throughput

0.494

High

895224

NRX3A
Neurexin-3

1

3

High-throughput

0.481

High

251203

RNBP6
Ran-binding protein 6

1

5

Small-scale

0.479

High

839205

MTOR
Serine/threonine-protein kinase mTOR

1

7

Small-scale

0.479

High

857067

NSF
Vesicle-fusing ATPase

1

2

Small-scale

0.479

High

895197

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

895205

TNPO1
Transportin-1

1

7

Small-scale

0.479

High

895209

EXOC2
Exocyst complex component 2

1

1

Small-scale

0.479

High

895193

DYN2
Dynamin-2

1

0

Small-scale

0.458

High

895208

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

Small-scale

0.458

High

895221

NCDN
Neurochondrin

1

0

Small-scale

0.458

High

895219

NRX3B
Neurexin-3-beta

1

1

High-throughput

0.457

High

189131

IPO8
Importin-8

1

9

Small-scale

0.437

High

220883

XPOT
Exportin-T

1

6

Small-scale

0.437

High

241108

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.437

High

273174

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

7

Small-scale

0.437

High

895198

ATM
Serine-protein kinase ATM

1

7

Small-scale

0.437

High

895199

ATR
Serine/threonine-protein kinase ATR

1

7

Small-scale

0.437

High

895211

SMG1
Serine/threonine-protein kinase SMG1

1

7

Small-scale

0.437

High

895212

CND3
Condensin complex subunit 3

1

1

Small-scale

0.437

High

895217

XPO4
Exportin-4

1

3

Small-scale

0.437

High

895222

COPG2
Coatomer subunit gamma-2

1

5

Small-scale

0.437

High

647334

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.282

High

869144

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.282

High

895200

RUN3A
RUN domain-containing protein 3A

1

0

High-throughput

0.282

High

895203

PARP8
Protein mono-ADP-ribosyltransferase PARP8

1

0

High-throughput

0.282

High

895207

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.282

High

895213

CMS1
Protein CMSS1

1

0

High-throughput

0.282

High

895215

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.282

High

208031

TTI1
TELO2-interacting protein 1 homolog

1

0

Small-scale

0.249

Low

895214

TBCD
Tubulin-specific chaperone D

1

0

Small-scale

0.249

Low

895225

TELO2
Telomere length regulation protein TEL2 homolog

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025