HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	33961781, 11494134, 9851874, 10829062, 10967110, 24287595, 10204582, 10372803, 16503409, 7517397
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, phage display, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030971 - receptor tyrosine kinase binding GO:0045296 - cadherin binding and 1 others more... GO:0046875 - ephrin receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 906
+	Hs
		208994 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610633 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		82738 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		B9EKI5_MOUSE (23-901): 0: 799: 47.22
+	Hs
		557678 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		209046 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		223012 NCK2_MOUSE (1-376): 3.75e-90: 277: 66.93		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Hs
		610281 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		298949 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610238 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		129202 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610595 SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		610546 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		140057 P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41		CBL_MOUSE (1-906): 0: 888: 91.59
+	Rn
		88780 P85A_RAT (241-376): 8.21e-22: 99.1: 19.57		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		298976 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		655351 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		129289 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Rn
		192744 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		SYNJ1_RAT (403-806): 2.87e-09: 63.4: 10.05