Protein: RPN8
26S proteasome regulatory subunit RPN8

Gene: RPN8
Organism: Saccharomyces cerevisiae S288C
Interactions: 122
UniProt ID: Q08723

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008237 - metallopeptidase activity
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850235

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

38

20

Small-scale

0.994

High

1064740

RPN5
26S proteasome regulatory subunit RPN5

15

20

Small-scale

0.986

High

1064742

RPN6
26S proteasome regulatory subunit RPN6

11

20

Small-scale

0.976

High

738345

RPN12
26S proteasome regulatory subunit RPN12

9

5

Small-scale

0.976

High

1044975

RPN9
26S proteasome regulatory subunit RPN9

9

20

Small-scale

0.974

High

803707

RPN1
26S proteasome regulatory subunit RPN1

9

16

Small-scale

0.967

High

751017

PRS7
26S proteasome regulatory subunit 7 homolog

8

20

Small-scale

0.965

High

806826

RPN10
26S proteasome regulatory subunit RPN10

6

5

Small-scale

0.947

High

740232

RPN2
26S proteasome regulatory subunit RPN2

6

16

High-throughput

0.943

High

817099

RPN3
26S proteasome regulatory subunit RPN3

6

12

Small-scale

0.938

High

1033899

PRS8
26S proteasome regulatory subunit 8 homolog

6

20

Small-scale

0.938

High

1053594

RPN7
26S proteasome regulatory subunit RPN7

5

20

High-throughput

0.925

High

750904

PRS6B
26S proteasome regulatory subunit 6B homolog

5

20

Small-scale

0.919

High

750795

PRS6A
26S proteasome regulatory subunit 6A

4

20

High-throughput

0.881

High

822441

PRS4
26S proteasome regulatory subunit 4 homolog

3

20

High-throughput

0.839

High

921112

PRS10
26S proteasome subunit RPT4

3

20

High-throughput

0.839

High

744022

RAD23
UV excision repair protein RAD23

3

20

High-throughput

0.830

High

1064738

RPN8
26S proteasome regulatory subunit RPN8

2

17

High-throughput

0.754

High

645214

PSB4
Proteasome subunit beta type-4

9

20

Small-scale

0.747

High

850355

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

7

High-throughput

0.716

High

918108

RPN14
26S proteasome regulatory subunit RPN14

5

5

Small-scale

0.716

High

821992

PSA6
Proteasome subunit alpha type-6

5

20

Small-scale

0.712

High

661442

PSA3
Proteasome subunit alpha type-3

4

20

Small-scale

0.691

High

721333

PSB7
Proteasome subunit beta type-7

4

20

Small-scale

0.691

High

803174

ECM29
Proteasome component ECM29

4

3

High-throughput

0.691

High

314913

SEM1
26S proteasome complex subunit SEM1

5

0

Small-scale

0.676

High

893078

PSD10
Probable 26S proteasome regulatory subunit p28

6

4

Small-scale

0.670

High

822025

PSA4
Proteasome subunit alpha type-4

3

20

Small-scale

0.656

High

661570

PSA2
Proteasome subunit alpha type-2

3

19

Small-scale

0.640

High

668415

PSB2
Proteasome subunit beta type-2

3

20

Small-scale

0.640

High

150314

RPN13
26S proteasome regulatory subunit RPN13

3

0

High-throughput

0.634

High

924464

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

2

Small-scale

0.595

High

636615

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.584

High

721286

PSB5
Proteasome subunit beta type-5

2

20

Small-scale

0.584

High

735964

PSA5
Proteasome subunit alpha type-5

2

20

Small-scale

0.584

High

509748

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

19

High-throughput

0.579

High

671205

SIS1
Protein SIS1

3

3

High-throughput

0.578

High

701743

URA7
CTP synthase 1

2

1

High-throughput

0.567

High

555279

RAD50
DNA repair protein RAD50

2

4

High-throughput

0.558

High

525408

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.552

High

1062880

RBX1
RING-box protein HRT1

1

9

High-throughput

0.536

High

580192

HSC82
ATP-dependent molecular chaperone HSC82

2

11

High-throughput

0.533

High

449368

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

1

High-throughput

0.489

High

470161

SPS1
Sporulation-specific protein 1

1

3

High-throughput

0.489

High

736147

ARP2
Actin-related protein 2

1

7

High-throughput

0.489

High

800774

RCK1
Serine/threonine-protein kinase RCK1

1

3

High-throughput

0.489

High

865288

LSM8
LSM2-LSM8 complex subunit LSM8

1

2

High-throughput

0.489

High

923140

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.489

High

1051645

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

3

High-throughput

0.489

High

636693

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.479

High

662059

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.479

High

675266

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.479

High

680126

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

776663

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

800866

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.479

High

1042258

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

763264

SQT1
Ribosome assembly protein SQT1

1

3

High-throughput

0.470

High

1063930

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.458

High

527899

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

742574

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

732082

SYKM
Lysine--tRNA ligase, mitochondrial

1

1

Small-scale

0.439

High

393467

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.437

High

394972

EF1A
Elongation factor 1-alpha

1

7

Small-scale

0.437

High

503283

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

557641

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

2

Small-scale

0.437

High

616457

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.437

High

647239

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

708415

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

708797

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

747617

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

753630

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

792288

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

800828

RCK2
Serine/threonine-protein kinase RCK2

1

2

High-throughput

0.437

High

802426

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

824805

MLP2
Protein MLP2

1

5

High-throughput

0.437

High

826324

PSMD9
Probable 26S proteasome regulatory subunit p27

1

2

Small-scale

0.437

High

844650

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

917332

INO80
Chromatin-remodeling ATPase INO80

1

6

Small-scale

0.437

High

1046072

DHR1
Probable ATP-dependent RNA helicase DHR1

1

4

High-throughput

0.437

High

1064739

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

1064743

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.437

High

546582

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.407

High

752835

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

811422

CAJ1
Protein CAJ1

1

3

High-throughput

0.407

High

820008

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.407

High

1056441

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

798575

HSM3
DNA mismatch repair protein HSM3

6

0

Small-scale

0.379

High

1061395

MLH2
DNA mismatch repair protein MLH2

2

0

High-throughput

0.324

High

1043570

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

657132

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.269

Low

737431

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

0

High-throughput

0.269

Low

813397

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.269

Low

761142

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.261

Low

1028040

ACAC
Acetyl-CoA carboxylase

1

0

Small-scale

0.251

Low

383929

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433885

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435411

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

436211

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

512694

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513264

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

594612

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

677601

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

679060

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

689703

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

735207

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

738935

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

764021

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

764168

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

778571

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

779362

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

780005

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.249

Low

782660

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.249

Low

795249

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

874571

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

877924

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

1025796

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.249

Low

1044807

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

1053995

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1054864

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

1064741

HSP42
Heat shock protein 42

1

0

Small-scale

0.249

Low

932637

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025