HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.697

Property	Details
Experiments	22745667, 9362449, 9010224, unassigned1973
Identification Methods	unspecified method, pull down, far western blotting, affinity chromatography technology, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding and 1 others more... GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 443
+	Mm
		1141333 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		209037 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Rn
		1144374 P85A_RAT (241-376): 8.21e-22: 99.1: 19.57		KHDR1_RAT (1-443): 0: 515: 94.36
+	Mm
		763394 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		980964 YES_MOUSE (5-201): 6.24e-20: 93.2: 16.42		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		655330 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		412149 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		442815 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		454827 FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		403437 SRC_MOUSE (5-114): 1.55e-15: 79.7: 22.32		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Mm
		1141126 GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		789110 FRK_HUMAN (3-127): 1.77e-17: 85.6: 22.39		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991778 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		522933 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		924509 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991902 ITSN2_HUMAN (7-85): 2.68e-12: 70.6: 24.05		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		209060 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33
+	Mm
		763412 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Mm
		1141173 GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Hs
		789069 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33