Protein: SRS2
ATP-dependent DNA helicase SRS2 (EC 5.6.2.4) (DNA 3'-5' helicase SRS2)

Gene: SRS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 160
UniProt ID: P12954

Gene Ontology (top 5):
GO:0000725 - recombinational repair
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

557657

PCNA
Proliferating cell nuclear antigen

9

1

Small-scale

0.759

High

557671

RAD51
DNA repair protein RAD51

12

4

Small-scale

0.758

High

557789

SMT3
Ubiquitin-like protein SMT3

7

2

Small-scale

0.752

High

448424

RAD52
DNA repair and recombination protein RAD52

3

1

Small-scale

0.655

High

557746

UBC9
SUMO-conjugating enzyme UBC9

2

3

Small-scale

0.622

High

557765

SIZ1
E3 SUMO-protein ligase SIZ1

2

3

Small-scale

0.614

High

557786

SIZ2
E3 SUMO-protein ligase SIZ2

2

3

Small-scale

0.614

High

557686

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.606

High

557670

RAD57
DNA repair protein RAD57

2

3

Small-scale

0.595

High

557707

RAD55
DNA repair protein RAD55

2

0

Small-scale

0.591

High

533466

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

2

1

Small-scale

0.584

High

557733

GLDS1
Protein GDS1

2

0

Small-scale

0.570

High

557685

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

2

0

Small-scale

0.569

High

364285

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.561

High

557715

EXO1
Exodeoxyribonuclease 1

1

5

Small-scale

0.561

High

557778

BRE1
E3 ubiquitin-protein ligase BRE1

1

3

Small-scale

0.561

High

557743

DPOD3
DNA polymerase delta subunit 3

2

0

Small-scale

0.559

High

557691

SGS1
ATP-dependent helicase SGS1

1

3

Small-scale

0.552

High

557782

ULS1
ATP-dependent helicase ULS1

1

1

Small-scale

0.552

High

557772

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.549

High

543635

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.536

High

557787

RAD59
DNA repair protein RAD59

1

1

Small-scale

0.527

High

557677

PYC2
Pyruvate carboxylase 2

1

1

High-throughput

0.515

High

557710

DUN1
DNA damage response protein kinase DUN1

1

0

High-throughput

0.513

High

557728

MSL1
U2 small nuclear ribonucleoprotein B''

1

4

High-throughput

0.508

High

557764

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.504

High

557774

ESC2
Protein ESC2

1

0

Small-scale

0.504

High

557688

RAD54
DNA repair and recombination protein RAD54

1

2

Small-scale

0.501

High

517861

SSBP1
Single-stranded nucleic acid-binding protein

1

6

High-throughput

0.500

High

557662

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

557757

ACT
Actin

1

1

High-throughput

0.500

High

557664

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.493

High

557738

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.493

High

557708

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

High-throughput

0.486

High

454645

RAD2
DNA repair protein RAD2

1

3

Small-scale

0.481

High

557667

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

Small-scale

0.481

High

557679

KNS1
Dual specificity protein kinase KNS1

1

1

Small-scale

0.481

High

557687

RAD5
DNA repair protein RAD5

1

3

Small-scale

0.481

High

557703

ECM29
Proteasome component ECM29

1

3

Small-scale

0.481

High

557712

IFH1
Protein IFH1

1

1

Small-scale

0.481

High

557724

ULP2
Ubiquitin-like-specific protease 2

1

2

Small-scale

0.481

High

557725

PDR11
ATP-dependent permease PDR11

1

1

Small-scale

0.481

High

557726

MPH1
ATP-dependent DNA helicase MPH1

1

3

Small-scale

0.481

High

557740

NMD5
Nonsense-mediated mRNA decay protein 5

1

2

Small-scale

0.481

High

557742

IKS1
Probable serine/threonine-protein kinase IKS1

1

2

Small-scale

0.481

High

557744

JHD2
Histone demethylase JHD2

1

1

Small-scale

0.481

High

557747

IMB5
Importin subunit beta-5

1

1

Small-scale

0.481

High

557751

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

3

Small-scale

0.481

High

557753

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

Small-scale

0.481

High

557758

SEN1
Helicase SEN1

1

2

Small-scale

0.481

High

557780

MLH2
DNA mismatch repair protein MLH2

1

1

Small-scale

0.481

High

557781

SMC5
Structural maintenance of chromosomes protein 5

1

5

Small-scale

0.481

High

557796

MTR10
mRNA transport regulator MTR10

1

2

Small-scale

0.481

High

557659

HXKG
Glucokinase-1

1

0

High-throughput

0.479

High

454063

DHE4
NADP-specific glutamate dehydrogenase 1

1

1

High-throughput

0.479

High

557674

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

557713

DHE5
NADP-specific glutamate dehydrogenase 2

1

1

High-throughput

0.479

High

557729

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

557759

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.479

High

557763

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

557750

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.470

High

557775

CORO
Coronin-like protein

1

4

High-throughput

0.470

High

448915

TOP2
DNA topoisomerase 2

1

0

Small-scale

0.460

High

557663

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

Small-scale

0.460

High

557665

KIN3
Serine/threonine-protein kinase KIN3

1

0

Small-scale

0.460

High

557668

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.460

High

557669

NAP1
Nucleosome assembly protein

1

0

Small-scale

0.460

High

557673

RAD14
DNA repair protein RAD14

1

0

Small-scale

0.460

High

557676

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.460

High

557678

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

Small-scale

0.460

High

557681

MEI5
Meiosis protein 5

1

0

Small-scale

0.460

High

557684

TOA1
Transcription initiation factor IIA large subunit

1

0

Small-scale

0.460

High

557702

KSP1
Serine/threonine-protein kinase KSP1

1

0

Small-scale

0.460

High

557704

ORC6
Origin recognition complex subunit 6

1

0

Small-scale

0.460

High

557709

SMC2
Structural maintenance of chromosomes protein 2

1

0

Small-scale

0.460

High

557716

SAP1
Protein SAP1

1

0

Small-scale

0.460

High

557720

GAT2
Protein GAT2

1

0

Small-scale

0.460

High

557730

MTA70
N(6)-adenosine-methyltransferase IME4

1

0

Small-scale

0.460

High

557739

COM1
DNA endonuclease SAE2

1

0

Small-scale

0.460

High

557749

YGK1
5'-deoxynucleotidase YGK1

1

0

Small-scale

0.460

High

557755

NIS1
Protein NIS1

1

0

Small-scale

0.460

High

557771

DUS3
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]

1

0

Small-scale

0.460

High

557773

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

Small-scale

0.460

High

557777

ELP1
Elongator complex protein 1

1

0

Small-scale

0.460

High

557791

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.460

High

557792

NDJ1
Non-disjunction protein 1

1

0

Small-scale

0.460

High

557793

CAF1A
Chromatin assembly factor 1 subunit A

1

0

Small-scale

0.460

High

504564

YD14B
Transposon Ty1-DR5 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

534170

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.458

High

557680

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.458

High

557697

SPO14
Phospholipase D1

1

0

High-throughput

0.458

High

557701

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.458

High

557711

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.458

High

557731

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

557732

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

557752

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.458

High

557768

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.458

High

408546

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

1

High-throughput

0.457

High

425100

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.457

High

484707

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

557660

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.457

High

522888

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

525777

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

557658

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

557675

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

557682

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

557693

LHS1
Heat shock protein 70 homolog LHS1

1

8

High-throughput

0.445

High

557736

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.445

High

358102

ADH1
Alcohol dehydrogenase 1

1

2

Small-scale

0.439

High

557661

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.439

High

557761

ESC1
Silent chromatin protein ESC1

1

3

Small-scale

0.439

High

557762

WDR59
Maintenance of telomere capping protein 5

1

4

Small-scale

0.439

High

557776

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

Small-scale

0.439

High

557705

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.437

High

557766

RRB1
Ribosome assembly protein RRB1

1

2

High-throughput

0.437

High

557769

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.437

High

557779

WHI4
Protein WHI4

1

1

High-throughput

0.437

High

557727

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.407

High

557754

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

557790

HSP42
Heat shock protein 42

2

0

High-throughput

0.307

High

557795

YB296
Uncharacterized protein YBR296C-A

1

0

High-throughput

0.282

High

455469

PMM
Phosphomannomutase

1

0

High-throughput

0.279

Low

557656

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.279

Low

557683

FIMB
Fimbrin

1

0

High-throughput

0.269

Low

368569

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

405007

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

557690

KTR2
Probable mannosyltransferase KTR2

1

0

Small-scale

0.251

Low

557692

NU120
Nucleoporin NUP120

1

0

Small-scale

0.251

Low

557695

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

Small-scale

0.251

Low

557696

BCH2
Protein BCH2

1

0

Small-scale

0.251

Low

557699

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

0

Small-scale

0.251

Low

557700

FZO1
Mitofusin FZO1

1

0

Small-scale

0.251

Low

557706

YH02
Uncharacterized protein YHR202W

1

0

Small-scale

0.251

Low

557714

HPH2
Protein HPH2

1

0

Small-scale

0.251

Low

557717

PPOX
Protoporphyrinogen oxidase

1

0

Small-scale

0.251

Low

557718

FIR1
Factor interacting with REF2

1

0

Small-scale

0.251

Low

557719

COX15
Heme A synthase COX15

1

0

Small-scale

0.251

Low

557722

YIQ1
Uncharacterized protein YIL161W

1

0

Small-scale

0.251

Low

557734

SSU1
Sulfite efflux pump SSU1

1

0

Small-scale

0.251

Low

557735

EGT2
Protein EGT2

1

0

Small-scale

0.251

Low

557741

ASG7
Protein ASG7

1

0

Small-scale

0.251

Low

557745

BNS1
Protein BNS1

1

0

Small-scale

0.251

Low

557760

HEH2
Inner nuclear membrane protein HEH2

1

0

Small-scale

0.251

Low

557767

GLU2B
Glucosidase 2 subunit beta

1

0

Small-scale

0.251

Low

557770

FAR8
Factor arrest protein 8

1

0

Small-scale

0.251

Low

557783

PLP2
Phosducin-like protein 2

1

0

Small-scale

0.251

Low

557785

SIA1
Protein SIA1

1

0

Small-scale

0.251

Low

557788

UBX3
UBX domain-containing protein 3

1

0

Small-scale

0.251

Low

557794

TAR1
Protein TAR1

1

0

Small-scale

0.251

Low

557666

MAN1
Alpha-mannosidase

1

0

High-throughput

0.249

Low

557672

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

High-throughput

0.249

Low

557689

SFC1
Succinate/fumarate mitochondrial transporter

1

0

High-throughput

0.249

Low

557698

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.249

Low

557721

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.249

Low

557723

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.249

Low

557737

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.249

Low

557748

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.249

Low

557756

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.249

Low

557784

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.249

Low

557694

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025