Protein: DUN1
DNA damage response protein kinase DUN1 (EC 2.7.11.1)

Gene: DUN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P39009

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

646402

RAD53
Serine/threonine-protein kinase RAD53

8

19

Small-scale

0.969

High

809098

SML1
Ribonucleotide reductase inhibitor protein SML1

7

1

Small-scale

0.751

High

809092

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.691

High

809108

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

6

High-throughput

0.691

High

656466

KC11
Casein kinase I homolog 1

1

17

High-throughput

0.656

High

470133

SPS1
Sporulation-specific protein 1

1

18

High-throughput

0.647

High

694136

CDC15
Cell division control protein 15

1

17

High-throughput

0.647

High

801827

KSP1
Serine/threonine-protein kinase KSP1

1

18

High-throughput

0.646

High

809091

ACT
Actin

1

6

High-throughput

0.646

High

361438

SODC
Superoxide dismutase [Cu-Zn]

2

1

Small-scale

0.639

High

441133

KAPA
cAMP-dependent protein kinase type 1

1

13

Small-scale

0.618

High

781090

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

Small-scale

0.589

High

544885

SSB1
Ribosome-associated molecular chaperone SSB1

2

12

High-throughput

0.584

High

809072

AKR1
Palmitoyltransferase AKR1

1

2

High-throughput

0.579

High

392733

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.575

High

739301

KAR9
Karyogamy protein KAR9

2

0

High-throughput

0.565

High

792809

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.541

High

448381

RAD1
DNA repair protein RAD1

1

1

High-throughput

0.536

High

453948

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.536

High

555250

RAD50
DNA repair protein RAD50

1

16

High-throughput

0.536

High

575281

RAD9
DNA repair protein RAD9

1

1

High-throughput

0.536

High

575947

CYPH
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.536

High

684072

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

1

High-throughput

0.536

High

744196

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.536

High

809073

RSP5
E3 ubiquitin-protein ligase RSP5

1

15

High-throughput

0.536

High

809102

RAD28
Radiation-sensitive protein 28

1

13

High-throughput

0.536

High

809105

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.536

High

809083

COM1
DNA endonuclease SAE2

1

1

Small-scale

0.527

High

809087

CWC23
Pre-mRNA-splicing factor CWC23

1

8

High-throughput

0.514

High

809090

JJJ1
J protein JJJ1

1

10

High-throughput

0.514

High

448965

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.513

High

557710

SRS2
ATP-dependent DNA helicase SRS2

1

0

High-throughput

0.513

High

566505

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.513

High

702247

YJU2
Splicing factor YJU2

1

0

High-throughput

0.513

High

809099

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.513

High

793402

ATM
Serine/threonine-protein kinase TEL1

1

20

Small-scale

0.501

High

793420

ATR
Serine/threonine-protein kinase MEC1

1

20

Small-scale

0.501

High

809075

VHR2
Transcription factor VHR2

1

1

High-throughput

0.501

High

809080

TCPH
T-complex protein 1 subunit eta

1

17

High-throughput

0.501

High

809096

PANK
Pantothenate kinase CAB1

1

1

High-throughput

0.501

High

416433

HXKA
Hexokinase-1

1

5

High-throughput

0.500

High

416543

HXKB
Hexokinase-2

1

5

High-throughput

0.500

High

590626

HSP26
Heat shock protein 26

1

1

High-throughput

0.500

High

626739

HSP60
Heat shock protein 60, mitochondrial

1

10

High-throughput

0.500

High

809093

OYE2
NADPH dehydrogenase 2

1

1

High-throughput

0.500

High

763322

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.493

High

672585

YCP4
Flavoprotein-like protein YCP4

1

2

High-throughput

0.489

High

763532

ATG19
Autophagy-related protein 19

1

1

High-throughput

0.489

High

788417

PGM2
Phosphoglucomutase 2

1

1

High-throughput

0.489

High

793039

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.489

High

809081

AGX1
Alanine--glyoxylate aminotransferase 1

1

3

High-throughput

0.489

High

809084

NET1
Nucleolar protein NET1

1

2

High-throughput

0.489

High

809089

YG3A
Uncharacterized protein YGR130C

1

15

High-throughput

0.489

High

809100

EIS1
Eisosome protein 1

1

8

High-throughput

0.489

High

809104

PST2
Protoplast secreted protein 2

1

2

High-throughput

0.489

High

150335

DIF1
Damage-regulated import facilitator 1

1

0

Small-scale

0.480

High

534185

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.480

High

806262

ADY1
Prospore formation at selected spindle poles protein 1

1

0

High-throughput

0.480

High

809076

YEQ9
Uncharacterized protein YER079W

1

0

High-throughput

0.480

High

809079

CUP9
Homeobox protein CUP9

1

0

High-throughput

0.480

High

809082

CHA4
Activatory protein CHA4

1

0

High-throughput

0.480

High

809085

YJ26
Uncharacterized protein YJR056C

1

0

High-throughput

0.480

High

439337

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

594371

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

721373

MCM4
DNA replication licensing factor MCM4

1

12

Small-scale

0.479

High

697328

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

707105

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

809094

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

809103

HSP42
Heat shock protein 42

1

1

High-throughput

0.457

High

809106

YG12A
Transposon Ty1-GR2 Gag polyprotein

1

3

High-throughput

0.457

High

560238

TOP3
DNA topoisomerase 3

1

1

High-throughput

0.457

High

781079

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

1

Small-scale

0.457

High

386709

TBB
Tubulin beta chain

1

11

High-throughput

0.457

High

405090

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

575453

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.457

High

809078

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.457

High

510491

HSP77
Import motor subunit, mitochondrial

1

16

High-throughput

0.445

High

523960

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

752262

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

809077

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

794033

KTR3
Probable mannosyltransferase KTR3

1

0

High-throughput

0.438

High

809107

DET1
Broad-range acid phosphatase DET1

1

0

High-throughput

0.438

High

631924

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.407

High

518720

ADH4
Alcohol dehydrogenase 4

1

0

High-throughput

0.279

Low

645820

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.279

Low

809095

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.279

Low

809088

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.269

Low

744709

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

0

High-throughput

0.261

Low

804697

HTD2
Hydroxyacyl-thioester dehydratase type 2, mitochondrial

1

0

High-throughput

0.261

Low

809074

GTT3
Glutathione transferase 3

1

0

High-throughput

0.261

Low

809097

YMI3
Putative uncharacterized protein YML083C

1

0

High-throughput

0.261

Low

809101

YL001
FAS1 domain-containing protein YLR001C

1

0

High-throughput

0.261

Low

439130

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

572582

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.261

Low

809086

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025