HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22267732
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 649
+	Hs
		557655 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		235470 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		208967 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Mm
		223015 NCK2_MOUSE (1-376): 3.75e-90: 277: 66.93		SRBS1_MOUSE (258-317): 7.05e-19: 93.7: 40.00
+	Hs
		209154 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		SRBS1_HUMAN (258-317): 1.89e-18: 92.2: 40.00
+	Hs
		788982 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		789054 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		655306 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		643091 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		129269 P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		763393 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		924617 SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		298959 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		235483 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		655439 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		412296 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		442869 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		454842 FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		298942 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		298986 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SH3R1_HUMAN (216-315): 3.02e-18: 91.4: 28.00