HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1620
+	Hs
		434130 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		208976 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		557644 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EPHB1_HUMAN (938-1436): 5.66e-129: 429: 25.25
+	Hs
		557701 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		557630 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		209056 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		507832 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		435526 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		209001 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		208983 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Rn
		88904 D4A3M8_RAT (1-376): 3.92e-90: 277: 66.93		INSR_RAT (973-1484): 1.45e-112: 392: 32.38
+	Hs
		788994 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Rn
		71362 B2RZ33_RAT (1-377): 8.61e-99: 300: 99.20		NTRK2_RAT (1093-1375): 8.02e-64: 236: 41.44
+	Hs
		557707 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Hs
		384213 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		557705 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		209065 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Hs
		209063 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Dm
		448247 NCK_DROME (5-374): 5.6e-68: 225: 42.54		INSR_DROME (1090-1384): 2.39e-63: 241: 39.03
+	Hs
		384434 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07