Protein: ERG
Transcriptional regulator ERG (Transforming protein ERG)

Gene: ERG
Organism: Homo sapiens
Interactions: 229
UniProt ID: P11308

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

540797

ETS2
Protein C-ets-2

2

18

Small-scale

0.783

High

540842

FLI1
Friend leukemia integration 1 transcription factor

2

18

Small-scale

0.754

High

519691

ANDR
Androgen receptor

4

12

Small-scale

0.694

High

486895

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.664

High

540839

PRKDC
DNA-dependent protein kinase catalytic subunit

2

8

Small-scale

0.664

High

227338

SPOP
Speckle-type POZ protein

2

4

Small-scale

0.657

High

540924

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

9

Small-scale

0.639

High

171999

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

2

7

Small-scale

0.624

High

428583

RLA0
Large ribosomal subunit protein uL10

2

1

Small-scale

0.624

High

540807

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

6

Small-scale

0.624

High

540835

ACTB
Actin, cytoplasmic 1

2

3

Small-scale

0.624

High

540841

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

13

Small-scale

0.624

High

540872

PCBP1
Poly(rC)-binding protein 1

2

1

Small-scale

0.624

High

540891

PRP8
Pre-mRNA-processing-splicing factor 8

2

1

Small-scale

0.624

High

540792

ERG
Transcriptional regulator ERG

1

17

Small-scale

0.618

High

540802

SPI1
Transcription factor PU.1

1

17

Small-scale

0.618

High

540825

ETV1
ETS translocation variant 1

1

18

Small-scale

0.618

High

540895

BCOR
BCL-6 corepressor

1

13

High-throughput

0.618

High

540905

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.618

High

540949

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.618

High

297423

PIAS1
E3 SUMO-protein ligase PIAS1

2

14

High-throughput

0.614

High

540925

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

12

High-throughput

0.614

High

540848

RING1
E3 ubiquitin-protein ligase RING1

2

20

Small-scale

0.595

High

540970

TRI33
E3 ubiquitin-protein ligase TRIM33

2

20

Small-scale

0.595

High

536379

HSP7C
Heat shock cognate 71 kDa protein

2

6

Small-scale

0.584

High

540850

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

142799

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.578

High

540852

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.578

High

540862

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

Small-scale

0.578

High

258742

DNJA2
DnaJ homolog subfamily A member 2

1

4

Small-scale

0.561

High

273396

KDM4A
Lysine-specific demethylase 4A

1

4

Small-scale

0.561

High

280479

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

Small-scale

0.561

High

289418

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

7

Small-scale

0.561

High

446590

NPM
Nucleophosmin

1

1

Small-scale

0.561

High

462217

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

Small-scale

0.561

High

473749

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

484873

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

Small-scale

0.561

High

532315

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.561

High

540794

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.561

High

540803

NUCL
Nucleolin

1

2

Small-scale

0.561

High

540808

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

Small-scale

0.561

High

540817

DNJA1
DnaJ homolog subfamily A member 1

1

4

Small-scale

0.561

High

540818

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

5

Small-scale

0.561

High

540819

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

Small-scale

0.561

High

540830

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

5

Small-scale

0.561

High

540833

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

Small-scale

0.561

High

540843

TOP2B
DNA topoisomerase 2-beta

1

1

Small-scale

0.561

High

540853

ILF2
Interleukin enhancer-binding factor 2

1

2

Small-scale

0.561

High

540854

ILF3
Interleukin enhancer-binding factor 3

1

3

Small-scale

0.561

High

540861

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

7

Small-scale

0.561

High

540867

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.561

High

540868

NUMA1
Nuclear mitotic apparatus protein 1

1

1

Small-scale

0.561

High

540871

NONO
Non-POU domain-containing octamer-binding protein

1

3

Small-scale

0.561

High

540873

SF3B3
Splicing factor 3B subunit 3

1

4

Small-scale

0.561

High

540876

ELAV1
ELAV-like protein 1

1

1

Small-scale

0.561

High

540880

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

13

Small-scale

0.561

High

540933

CDC5L
Cell division cycle 5-like protein

1

6

Small-scale

0.561

High

540935

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

7

Small-scale

0.561

High

540941

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

13

Small-scale

0.561

High

540942

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

Small-scale

0.561

High

540957

DDX21
Nucleolar RNA helicase 2

1

5

Small-scale

0.561

High

540959

RCC2
Protein RCC2

1

2

Small-scale

0.561

High

540966

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

Small-scale

0.561

High

74748

B2Y833
TMPRSS2-ERG prostate cancer specific isoform 1

1

15

Small-scale

0.559

High

540795

XRCC6
X-ray repair cross-complementing protein 6

1

12

Small-scale

0.554

High

540796

XRCC5
X-ray repair cross-complementing protein 5

1

12

Small-scale

0.554

High

540821

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.541

High

540834

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.541

High

540877

NDF2
Neurogenic differentiation factor 2

1

10

High-throughput

0.541

High

540896

RN111
E3 ubiquitin-protein ligase Arkadia

1

8

High-throughput

0.541

High

540904

HIPK1
Homeodomain-interacting protein kinase 1

1

6

High-throughput

0.541

High

540906

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.541

High

540908

ZBT44
Zinc finger and BTB domain-containing protein 44

1

5

High-throughput

0.541

High

540947

WDR13
WD repeat-containing protein 13

1

10

High-throughput

0.541

High

540961

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.541

High

540963

ZMYM2
Zinc finger MYM-type protein 2

1

6

High-throughput

0.541

High

540978

PIAS3
E3 SUMO-protein ligase PIAS3

1

14

High-throughput

0.541

High

257732

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

Small-scale

0.537

High

285788

SF3B1
Splicing factor 3B subunit 1

1

0

Small-scale

0.537

High

540806

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.537

High

540811

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.537

High

540822

MATR3
Matrin-3

1

0

Small-scale

0.537

High

540840

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.537

High

540857

SF3B2
Splicing factor 3B subunit 2

1

0

Small-scale

0.537

High

540944

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.537

High

540912

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

High-throughput

0.536

High

540805

MSH3
DNA mismatch repair protein Msh3

1

0

High-throughput

0.518

High

540809

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

0

High-throughput

0.518

High

540828

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.518

High

540847

EXOS9
Exosome complex component RRP45

1

0

High-throughput

0.518

High

540855

TARB1
tRNA

1

0

High-throughput

0.518

High

540882

ZBED5
Zinc finger BED domain-containing protein 5

1

0

High-throughput

0.518

High

540927

ARK2N
Protein ARK2N

1

0

High-throughput

0.518

High

540975

MYO5A
Unconventional myosin-Va

1

0

High-throughput

0.518

High

540800

SYN1
Synapsin-1

1

20

Small-scale

0.512

High

540846

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.512

High

325658

UBR5
E3 ubiquitin-protein ligase UBR5

1

5

Small-scale

0.501

High

342727

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

Small-scale

0.501

High

421392

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

429198

JUN
Transcription factor Jun

1

17

Small-scale

0.501

High

540863

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

5

Small-scale

0.501

High

540886

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.501

High

540887

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.501

High

540901

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

Small-scale

0.501

High

540915

DNJA4
DnaJ homolog subfamily A member 4

1

4

Small-scale

0.501

High

540932

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

20

Small-scale

0.501

High

540934

RING2
E3 ubiquitin-protein ligase RING2

1

20

Small-scale

0.501

High

540969

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.501

High

540816

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.500

High

138965

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

141298

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

Small-scale

0.479

High

154616

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161401

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174303

ZN609
Zinc finger protein 609

1

13

High-throughput

0.479

High

180677

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

194502

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

259355

BRD4
Bromodomain-containing protein 4

1

20

Small-scale

0.479

High

269087

MITF
Microphthalmia-associated transcription factor

1

2

High-throughput

0.479

High

273972

CREST
Calcium-responsive transactivator

1

20

High-throughput

0.479

High

278219

NCOR1
Nuclear receptor corepressor 1

1

16

High-throughput

0.479

High

426186

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

1

Small-scale

0.479

High

457192

TBB5
Tubulin beta chain

1

8

Small-scale

0.479

High

465383

IGF1R
Insulin-like growth factor 1 receptor

1

5

Small-scale

0.479

High

482823

TPM1
Tropomyosin alpha-1 chain

1

3

Small-scale

0.479

High

505511

ATX1L
Ataxin-1-like

1

10

High-throughput

0.479

High

540793

PIM1
Serine/threonine-protein kinase pim-1

1

2

Small-scale

0.479

High

540799

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.479

High

540801

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

Small-scale

0.479

High

540804

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

Small-scale

0.479

High

540810

IBP5
Insulin-like growth factor-binding protein 5

1

1

High-throughput

0.479

High

540812

BRD2
Bromodomain-containing protein 2

1

20

Small-scale

0.479

High

540814

RBTN2
Rhombotin-2

1

10

Small-scale

0.479

High

540815

PYR1
Multifunctional protein CAD

1

2

Small-scale

0.479

High

540820

HSP74
Heat shock 70 kDa protein 4

1

7

Small-scale

0.479

High

540823

GATA4
Transcription factor GATA-4

1

9

High-throughput

0.479

High

540824

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.479

High

540826

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

17

High-throughput

0.479

High

540827

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

19

High-throughput

0.479

High

540829

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

Small-scale

0.479

High

540831

ATX1
Ataxin-1

1

10

High-throughput

0.479

High

540832

AF10
Protein AF-10

1

5

High-throughput

0.479

High

540836

LMO4
LIM domain transcription factor LMO4

1

10

High-throughput

0.479

High

540837

RS18
Small ribosomal subunit protein uS13

1

1

Small-scale

0.479

High

540838

RL7A
Large ribosomal subunit protein eL8

1

1

Small-scale

0.479

High

540844

TLE1
Transducin-like enhancer protein 1

1

19

High-throughput

0.479

High

540845

TLE3
Transducin-like enhancer protein 3

1

18

High-throughput

0.479

High

540849

TLE5
TLE family member 5

1

14

High-throughput

0.479

High

540851

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.479

High

540858

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

540859

CUL3
Cullin-3

1

1

Small-scale

0.479

High

540860

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

3

Small-scale

0.479

High

540864

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.479

High

540866

MEF2D
Myocyte-specific enhancer factor 2D

1

1

High-throughput

0.479

High

540869

SETB1
Histone-lysine N-methyltransferase SETDB1

1

15

Small-scale

0.479

High

540870

BRD3
Bromodomain-containing protein 3

1

20

Small-scale

0.479

High

540874

SSXT
Protein SSXT

1

20

High-throughput

0.479

High

540875

NCOA2
Nuclear receptor coactivator 2

1

19

High-throughput

0.479

High

540878

EZH2
Histone-lysine N-methyltransferase EZH2

1

19

Small-scale

0.479

High

540883

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

540884

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

7

High-throughput

0.479

High

540885

PRC2B
Protein PRRC2B

1

20

High-throughput

0.479

High

540888

NIPBL
Nipped-B-like protein

1

9

High-throughput

0.479

High

540890

ZN746
Zinc finger protein 746

1

3

High-throughput

0.479

High

540892

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

3

High-throughput

0.479

High

540893

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

12

High-throughput

0.479

High

540894

MCAF1
Activating transcription factor 7-interacting protein 1

1

19

High-throughput

0.479

High

540897

CO039
Uncharacterized protein C15orf39

1

9

High-throughput

0.479

High

540898

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.479

High

540899

ASXL2
Putative Polycomb group protein ASXL2

1

20

High-throughput

0.479

High

540900

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

High-throughput

0.479

High

540902

LDB1
LIM domain-binding protein 1

1

1

High-throughput

0.479

High

540903

ZFHX4
Zinc finger homeobox protein 4

1

4

High-throughput

0.479

High

540907

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.479

High

540909

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

540910

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

540911

KDM2B
Lysine-specific demethylase 2B

1

16

High-throughput

0.479

High

540913

MORC4
MORC family CW-type zinc finger protein 4

1

3

High-throughput

0.479

High

540914

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

7

High-throughput

0.479

High

540916

MAML1
Mastermind-like protein 1

1

20

High-throughput

0.479

High

540917

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.479

High

540918

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

540919

DPF3
Zinc finger protein DPF3

1

20

High-throughput

0.479

High

540920

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

540921

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

540922

SMRC1
SWI/SNF complex subunit SMARCC1

1

18

High-throughput

0.479

High

540923

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

540926

ISL2
Insulin gene enhancer protein ISL-2

1

6

High-throughput

0.479

High

540928

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

540929

ZN521
Zinc finger protein 521

1

1

High-throughput

0.479

High

540931

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

540936

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

540937

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

7

High-throughput

0.479

High

540938

PYGO2
Pygopus homolog 2

1

1

High-throughput

0.479

High

540939

PCGF1
Polycomb group RING finger protein 1

1

14

High-throughput

0.479

High

540943

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

6

Small-scale

0.479

High

540945

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

1

High-throughput

0.479

High

540946

RBNS5
Rabenosyn-5

1

1

High-throughput

0.479

High

540948

HIPK2
Homeodomain-interacting protein kinase 2

1

2

High-throughput

0.479

High

540951

ZN703
Zinc finger protein 703

1

4

High-throughput

0.479

High

540955

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

540956

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

540958

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

20

High-throughput

0.479

High

540960

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

12

High-throughput

0.479

High

540962

RERE
Arginine-glutamic acid dipeptide repeats protein

1

14

High-throughput

0.479

High

540964

TCF20
Transcription factor 20

1

17

High-throughput

0.479

High

540965

TRPS1
Zinc finger transcription factor Trps1

1

10

High-throughput

0.479

High

540967

ZN608
Zinc finger protein 608

1

5

High-throughput

0.479

High

540968

PRR12
Proline-rich protein 12

1

19

High-throughput

0.479

High

540971

SATB2
DNA-binding protein SATB2

1

5

High-throughput

0.479

High

540972

ZN148
Zinc finger protein 148

1

10

High-throughput

0.479

High

540973

ZN281
Zinc finger protein 281

1

10

High-throughput

0.479

High

540974

ARIP4
Helicase ARIP4

1

20

High-throughput

0.479

High

540976

NCOR2
Nuclear receptor corepressor 2

1

11

High-throughput

0.479

High

540977

NCOA3
Nuclear receptor coactivator 3

1

19

High-throughput

0.479

High

540798

NDKA
Nucleoside diphosphate kinase A

1

0

Small-scale

0.458

High

540856

XRCC4
DNA repair protein XRCC4

1

0

Small-scale

0.458

High

540889

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

540940

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.458

High

540953

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

540879

DREB
Drebrin

1

2

High-throughput

0.457

High

540813

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

540865

GSE1
Genetic suppressor element 1

1

1

High-throughput

0.437

High

540881

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

540950

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

540952

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

540954

FBSL
Fibrosin-1-like protein

1

3

High-throughput

0.437

High

228434

LANC1
Glutathione S-transferase LANCL1

1

0

Small-scale

0.292

High

540930

F218A
Protein FAM218A

1

0

High-throughput

0.282

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025