Protein: ERF
ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)

Gene: ERF
Organism: Homo sapiens
Interactions: 178
UniProt ID: P50548

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

896477

ASB3
Ankyrin repeat and SOCS box protein 3

2

0

High-throughput

0.770

High

703502

MK01
Mitogen-activated protein kinase 1

4

19

High-throughput

0.678

High

896360

ANM2
Protein arginine N-methyltransferase 2

3

3

High-throughput

0.667

High

896385

MK14
Mitogen-activated protein kinase 14

3

20

High-throughput

0.667

High

896401

OLFM4
Olfactomedin-4

3

2

High-throughput

0.667

High

896444

CAB45
45 kDa calcium-binding protein

3

3

High-throughput

0.667

High

896445

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

6

High-throughput

0.667

High

896456

ANTR1
Anthrax toxin receptor 1

3

3

High-throughput

0.667

High

846896

ETV4
ETS translocation variant 4

1

16

High-throughput

0.665

High

896464

ZRAN1
Ubiquitin thioesterase ZRANB1

3

3

High-throughput

0.653

High

691681

MK03
Mitogen-activated protein kinase 3

2

19

High-throughput

0.628

High

896362

DCAF7
DDB1- and CUL4-associated factor 7

2

2

High-throughput

0.628

High

896374

CDC16
Cell division cycle protein 16 homolog

2

1

High-throughput

0.628

High

896378

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.628

High

896478

PCDBB
Protocadherin beta-11

2

1

High-throughput

0.628

High

896369

TF65
Transcription factor p65

1

13

High-throughput

0.618

High

896367

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

1

High-throughput

0.609

High

896371

TLE5
TLE family member 5

2

14

High-throughput

0.606

High

896431

MCRS1
Microspherule protein 1

2

4

High-throughput

0.606

High

896388

AOC3
Amine oxidase [copper-containing] 3

2

0

High-throughput

0.602

High

261385

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

15

High-throughput

0.601

High

896469

KLF15
Krueppel-like factor 15

2

20

High-throughput

0.584

High

896366

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

0

High-throughput

0.576

High

866428

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

2

1

High-throughput

0.574

High

227433

SPOP
Speckle-type POZ protein

1

4

Small-scale

0.561

High

896466

DDX20
Probable ATP-dependent RNA helicase DDX20

1

5

Small-scale

0.561

High

431473

THBG
Thyroxine-binding globulin

2

6

High-throughput

0.558

High

896389

INF2
Inverted formin-2

2

3

High-throughput

0.549

High

896397

SE1L3
Protein sel-1 homolog 3

2

1

High-throughput

0.549

High

174979

SC16A
Protein transport protein Sec16A

1

12

High-throughput

0.536

High

261480

B4GT2
Beta-1,4-galactosyltransferase 2

1

1

High-throughput

0.536

High

296764

ST1C4
Sulfotransferase 1C4

1

3

High-throughput

0.536

High

334159

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

366243

FA9
Coagulation factor IX

1

3

High-throughput

0.536

High

407601

S100B
Protein S100-B

1

6

High-throughput

0.536

High

559269

XRCC5
X-ray repair cross-complementing protein 5

1

10

High-throughput

0.536

High

783536

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

High-throughput

0.536

High

880121

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.536

High

896368

PPARD
Peroxisome proliferator-activated receptor delta

1

5

High-throughput

0.536

High

896387

PRSS8
Prostasin

1

1

High-throughput

0.536

High

896409

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

6

High-throughput

0.536

High

896420

DNJB8
DnaJ homolog subfamily B member 8

1

3

High-throughput

0.536

High

896427

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

896429

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

896434

HES6
Transcription cofactor HES-6

1

1

High-throughput

0.536

High

896442

NPAS1
Neuronal PAS domain-containing protein 1

1

7

High-throughput

0.536

High

896443

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

1

15

High-throughput

0.536

High

896447

TCAB1
Telomerase Cajal body protein 1

1

15

High-throughput

0.536

High

896448

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

15

High-throughput

0.536

High

896449

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

896454

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.536

High

896455

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

896470

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

220884

XPOT
Exportin-T

1

4

High-throughput

0.515

High

896398

Q6FHY5
MEOX2 protein

1

20

High-throughput

0.515

High

191308

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

341295

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

876778

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.513

High

896382

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.513

High

896400

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

896411

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.513

High

896438

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

896439

GCP5
Gamma-tubulin complex component 5

1

0

High-throughput

0.513

High

896405

RHOU
Rho-related GTP-binding protein RhoU

1

8

High-throughput

0.501

High

73783

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

1

High-throughput

0.489

High

337506

MATN4
Matrilin-4

1

3

High-throughput

0.489

High

896363

LCN6
Epididymal-specific lipocalin-6

1

2

High-throughput

0.489

High

896396

OLM2B
Olfactomedin-like protein 2B

1

2

High-throughput

0.489

High

896415

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

5

High-throughput

0.489

High

896416

KLH34
Kelch-like protein 34

1

5

High-throughput

0.489

High

896418

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

896423

ITLN1
Intelectin-1

1

1

High-throughput

0.489

High

896430

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

3

High-throughput

0.489

High

896441

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.489

High

896450

DNAI2
Dynein axonemal intermediate chain 2

1

14

High-throughput

0.489

High

896451

CAD23
Cadherin-23

1

1

High-throughput

0.489

High

893762

MEOX2
Homeobox protein MOX-2

1

20

High-throughput

0.481

High

142899

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

172589

XPO1
Exportin-1

1

6

High-throughput

0.479

High

209968

CRX
Cone-rod homeobox protein

1

14

High-throughput

0.479

High

342129

BRD1
Bromodomain-containing protein 1

1

20

High-throughput

0.479

High

473862

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

896364

H4
Histone H4

1

3

High-throughput

0.479

High

896365

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

896372

RBBP4
Histone-binding protein RBBP4

1

8

High-throughput

0.479

High

896373

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

896380

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

896395

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

7

High-throughput

0.479

High

896403

PAXI1
PAX-interacting protein 1

1

17

High-throughput

0.479

High

896414

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

Small-scale

0.479

High

896419

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.479

High

783202

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.458

High

896459

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

896474

NISCH
Nischarin

1

0

High-throughput

0.458

High

159572

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

6

High-throughput

0.445

High

188217

HDAC3
Histone deacetylase 3

1

7

High-throughput

0.445

High

229423

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

1

High-throughput

0.445

High

299114

FLOT1
Flotillin-1

1

9

High-throughput

0.445

High

437646

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

442640

RB
Retinoblastoma-associated protein

1

2

High-throughput

0.445

High

547113

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.445

High

575126

IDE
Insulin-degrading enzyme

1

1

High-throughput

0.445

High

716105

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

2

High-throughput

0.445

High

858599

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

High-throughput

0.445

High

896359

EPHB4
Ephrin type-B receptor 4

1

5

High-throughput

0.445

High

896361

GSDMD
Gasdermin-D

1

1

High-throughput

0.445

High

896376

SKP2
S-phase kinase-associated protein 2

1

10

High-throughput

0.445

High

896379

PUM1
Pumilio homolog 1

1

1

High-throughput

0.445

High

896383

SKI2
Superkiller complex protein 2

1

5

High-throughput

0.445

High

896386

MAPK3
MAP kinase-activated protein kinase 3

1

2

High-throughput

0.445

High

896390

ERC6L
DNA excision repair protein ERCC-6-like

1

20

High-throughput

0.445

High

896391

QRIC1
Transcriptional regulator QRICH1

1

16

High-throughput

0.445

High

896407

AACS
Acetoacetyl-CoA synthetase

1

1

High-throughput

0.445

High

896413

RPTOR
Regulatory-associated protein of mTOR

1

20

High-throughput

0.445

High

896421

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

High-throughput

0.445

High

896422

CTF18
Chromosome transmission fidelity protein 18 homolog

1

3

High-throughput

0.445

High

896437

NSUN5
28S rRNA

1

3

High-throughput

0.445

High

896440

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

10

High-throughput

0.445

High

896458

SYF1
Pre-mRNA-splicing factor SYF1

1

10

High-throughput

0.445

High

896460

HELLS
Lymphoid-specific helicase

1

20

High-throughput

0.445

High

896467

XPO7
Exportin-7

1

6

High-throughput

0.445

High

896468

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

1

High-throughput

0.445

High

896471

TTF2
Transcription termination factor 2

1

20

High-throughput

0.445

High

896472

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

10

High-throughput

0.445

High

896480

SNX8
Sorting nexin-8

1

2

High-throughput

0.445

High

896481

FHOD1
FH1/FH2 domain-containing protein 1

1

3

High-throughput

0.445

High

896482

NCOR2
Nuclear receptor corepressor 2

1

13

High-throughput

0.445

High

176655

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.426

High

291258

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.426

High

301868

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

319533

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.426

High

326535

MFN2
Mitofusin-2

1

0

High-throughput

0.426

High

354452

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.426

High

359798

DYR
Dihydrofolate reductase

1

0

High-throughput

0.426

High

486549

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.426

High

827349

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.426

High

844739

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

851850

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.426

High

896370

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.426

High

896375

GPS2
G protein pathway suppressor 2

1

0

High-throughput

0.426

High

896377

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.426

High

896381

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

896404

UN13D
Protein unc-13 homolog D

1

0

High-throughput

0.426

High

896410

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.426

High

896412

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

0

High-throughput

0.426

High

896425

TBCD5
TBC1 domain family member 5

1

0

High-throughput

0.426

High

896426

SYMPK
Symplekin

1

0

High-throughput

0.426

High

896435

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.426

High

896436

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.426

High

896453

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

896462

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.426

High

896475

KAD6
Adenylate kinase isoenzyme 6

1

0

High-throughput

0.426

High

896479

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

0

High-throughput

0.426

High

896358

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

1

High-throughput

0.407

High

896392

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

2

High-throughput

0.407

High

896399

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

2

High-throughput

0.407

High

896402

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

896406

NOP9
Nucleolar protein 9

1

1

High-throughput

0.407

High

896417

ARM10
Armadillo repeat-containing protein 10

1

1

High-throughput

0.407

High

896473

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

High-throughput

0.407

High

847768

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

896393

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

896394

KHDC1
KH homology domain-containing protein 1

1

0

High-throughput

0.279

Low

896424

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.279

Low

896432

MT25B
Methyltransferase-like protein 25B

1

0

High-throughput

0.279

Low

896433

PAGE5
P antigen family member 5

1

0

High-throughput

0.279

Low

896465

IL17B
Interleukin-17B

1

0

High-throughput

0.279

Low

896476

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.249

Low

296108

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

0

High-throughput

0.232

Low

350356

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

High-throughput

0.232

Low

896384

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

896408

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.232

Low

896428

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.232

Low

896446

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.232

Low

896452

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.232

Low

896457

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.232

Low

896461

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.232

Low

896463

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025