Protein: ETS1
Protein C-ets-1 (p54)

Gene: ETS1
Organism: Homo sapiens
Interactions: 160
UniProt ID: P14921

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

577479

CBP
CREB-binding protein

5

20

Small-scale

0.716

High

413118

P53
Cellular tumor antigen p53

4

5

Small-scale

0.676

High

577394

ETS2
Protein C-ets-2

1

19

Small-scale

0.647

High

577401

SPI1
Transcription factor PU.1

1

18

Small-scale

0.647

High

577432

FOXO1
Forkhead box protein O1

1

17

Small-scale

0.647

High

577393

ETS1
Protein C-ets-1

1

18

High-throughput

0.646

High

577425

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

11

Small-scale

0.646

High

429236

JUN
Transcription factor Jun

2

17

Small-scale

0.639

High

577507

DAXX
Death domain-associated protein 6

3

0

Small-scale

0.630

High

339132

TYDP2
Tyrosyl-DNA phosphodiesterase 2

2

1

Small-scale

0.628

High

340816

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

16

Small-scale

0.618

High

577403

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

11

High-throughput

0.618

High

577437

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.618

High

577428

SRS11
Serine/arginine-rich splicing factor 11

2

2

High-throughput

0.614

High

577398

CREB1
Cyclic AMP-responsive element-binding protein 1

2

4

Small-scale

0.595

High

577470

COP1
E3 ubiquitin-protein ligase COP1

1

17

Small-scale

0.589

High

486913

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.585

High

557826

XRCC6
X-ray repair cross-complementing protein 6

2

12

Small-scale

0.585

High

577417

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

2

17

High-throughput

0.584

High

577465

PIAS4
E3 SUMO-protein ligase PIAS4

2

14

Small-scale

0.584

High

577444

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.578

High

577431

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.571

High

577402

NUCL
Nucleolin

1

2

High-throughput

0.561

High

577430

APLP2
Amyloid beta precursor like protein 2

1

12

High-throughput

0.561

High

577435

MK07
Mitogen-activated protein kinase 7

1

19

Small-scale

0.561

High

258067

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.554

High

577423

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.550

High

577413

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.537

High

577448

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.537

High

577407

SP100
Nuclear autoantigen Sp-100

1

17

Small-scale

0.529

High

577422

UBC9
SUMO-conjugating enzyme UBC9

1

9

Small-scale

0.527

High

137119

MEIS1
Homeobox protein Meis1

1

2

Small-scale

0.515

High

177782

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

2

Small-scale

0.515

High

577500

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

3

High-throughput

0.515

High

577404

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

0

High-throughput

0.513

High

577505

THUM1
THUMP domain-containing protein 1

1

0

High-throughput

0.513

High

421433

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

464785

SP1
Transcription factor Sp1

1

20

Small-scale

0.501

High

577395

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

12

Small-scale

0.501

High

577406

TBP
TATA-box-binding protein

1

3

Small-scale

0.501

High

577408

PIT1
Pituitary-specific positive transcription factor 1

1

12

Small-scale

0.501

High

577412

BRCA1
Breast cancer type 1 susceptibility protein

1

8

Small-scale

0.501

High

577429

MTG8
Protein CBFA2T1

1

2

Small-scale

0.501

High

577436

RUNX2
Runt-related transcription factor 2

1

4

Small-scale

0.501

High

577501

SRA1
Steroid receptor RNA activator 1

1

1

Small-scale

0.501

High

577400

TAL1
T-cell acute lymphocytic leukemia protein 1

1

15

Small-scale

0.500

High

577459

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

10

Small-scale

0.481

High

282155

MAF
Transcription factor Maf

1

0

Small-scale

0.480

High

577510

DNM3L
DNA

1

0

Small-scale

0.480

High

154621

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161403

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

180689

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

194504

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

224934

TLX3
T-cell leukemia homeobox protein 3

1

13

Small-scale

0.479

High

273974

CREST
Calcium-responsive transactivator

1

20

High-throughput

0.479

High

278226

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.479

High

317548

SLIT2
Slit homolog 2 protein

1

1

High-throughput

0.479

High

320308

PHF14
PHD finger protein 14

1

4

High-throughput

0.479

High

334503

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.479

High

415317

HSPB1
Heat shock protein beta-1

1

4

Small-scale

0.479

High

451475

CENPB
Major centromere autoantigen B

1

5

High-throughput

0.479

High

460421

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

469704

MMP3
Stromelysin-1

1

1

Small-scale

0.479

High

481070

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

577396

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.479

High

577399

JUND
Transcription factor JunD

1

15

High-throughput

0.479

High

577410

TLX1
T-cell leukemia homeobox protein 1

1

19

Small-scale

0.479

High

577414

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

577415

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.479

High

577416

TAF6
Transcription initiation factor TFIID subunit 6

1

5

High-throughput

0.479

High

577418

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

19

High-throughput

0.479

High

577419

TTC3
E3 ubiquitin-protein ligase TTC3

1

4

High-throughput

0.479

High

577426

SET
Protein SET

1

1

High-throughput

0.479

High

577427

TLE3
Transducin-like enhancer protein 3

1

17

High-throughput

0.479

High

577433

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.479

High

577434

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

577438

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

5

High-throughput

0.479

High

577441

NCOA1
Nuclear receptor coactivator 1

1

19

Small-scale

0.479

High

577445

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

7

High-throughput

0.479

High

577449

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

577450

ELP2
Elongator complex protein 2

1

4

High-throughput

0.479

High

577451

NFRKB
Nuclear factor related to kappa-B-binding protein

1

16

High-throughput

0.479

High

577453

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

12

High-throughput

0.479

High

577454

SRCAP
Helicase SRCAP

1

20

High-throughput

0.479

High

577455

UBN2
Ubinuclein-2

1

20

High-throughput

0.479

High

577456

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.479

High

577458

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

High-throughput

0.479

High

577460

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

Small-scale

0.479

High

577462

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

577463

MGAP
MAX gene-associated protein

1

6

High-throughput

0.479

High

577468

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

577469

KDM2B
Lysine-specific demethylase 2B

1

17

High-throughput

0.479

High

577471

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

High-throughput

0.479

High

577472

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

577473

GATD1
GATA zinc finger domain-containing protein 1

1

4

High-throughput

0.479

High

577474

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

7

High-throughput

0.479

High

577475

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

577476

TSC1
Hamartin

1

4

High-throughput

0.479

High

577477

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

577478

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

577480

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.479

High

577481

SMRC1
SWI/SNF complex subunit SMARCC1

1

18

High-throughput

0.479

High

577482

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

577484

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

12

High-throughput

0.479

High

577486

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

577487

ZFR
Zinc finger RNA-binding protein

1

2

High-throughput

0.479

High

577488

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

577490

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

577493

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.479

High

577494

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.479

High

577496

EPAS1
Endothelial PAS domain-containing protein 1

1

17

Small-scale

0.479

High

577502

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

577508

TRPS1
Zinc finger transcription factor Trps1

1

10

High-throughput

0.479

High

577514

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

14

Small-scale

0.479

High

577516

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.479

High

577517

PPME1
Protein phosphatase methylesterase 1

1

1

High-throughput

0.479

High

577518

NCOA3
Nuclear receptor coactivator 3

1

19

Small-scale

0.479

High

377945

TNFA
Tumor necrosis factor

1

0

Small-scale

0.458

High

572970

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.458

High

577420

RD23B
UV excision repair protein RAD23 homolog B

1

0

High-throughput

0.458

High

577421

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

577452

CPLX2
Complexin-2

1

0

High-throughput

0.458

High

577461

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

Small-scale

0.458

High

577466

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.458

High

577467

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

577483

TCAL3
Transcription elongation factor A protein-like 3

1

0

High-throughput

0.458

High

577485

DYL2
Dynein light chain 2, cytoplasmic

1

0

High-throughput

0.458

High

577489

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.458

High

577497

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

577499

CHM4A
Charged multivesicular body protein 4a

1

0

High-throughput

0.458

High

577503

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

577504

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.458

High

577509

SCOC
Short coiled-coil protein

1

0

High-throughput

0.458

High

577506

GGA3
ADP-ribosylation factor-binding protein GGA3

1

2

High-throughput

0.457

High

577511

GGA2
ADP-ribosylation factor-binding protein GGA2

1

2

High-throughput

0.457

High

557060

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.445

High

559204

XRCC5
X-ray repair cross-complementing protein 5

1

12

Small-scale

0.445

High

577397

ITF2
Transcription factor 4

1

2

Small-scale

0.445

High

577409

MK01
Mitogen-activated protein kinase 1

1

19

Small-scale

0.445

High

577411

CTNB1
Catenin beta-1

1

3

Small-scale

0.445

High

577442

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.445

High

451326

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.437

High

577424

ALEX
Protein ALEX

1

14

High-throughput

0.437

High

577439

PLEC
Plectin

1

1

Small-scale

0.437

High

577443

CP51A
Lanosterol 14-alpha demethylase

1

1

High-throughput

0.437

High

577457

SV2A
Synaptic vesicle glycoprotein 2A

1

1

High-throughput

0.437

High

577464

WDR17
WD repeat-containing protein 17

1

11

High-throughput

0.437

High

577491

PCX1
Pecanex-like protein 1

1

20

High-throughput

0.437

High

577492

KS6C1
Ribosomal protein S6 kinase delta-1

1

2

High-throughput

0.437

High

577495

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

2

Small-scale

0.437

High

577513

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

577512

GGA1
ADP-ribosylation factor-binding protein GGA1

1

2

High-throughput

0.408

High

577515

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.408

High

577405

KLK2
Kallikrein-2

1

6

High-throughput

0.407

High

577498

CYBC1
Cytochrome b-245 chaperone 1

1

0

High-throughput

0.301

High

577440

CH3L2
Chitinase-3-like protein 2

1

0

High-throughput

0.279

Low

187638

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.249

Low

577446

NOMO2
BOS complex subunit NOMO2

1

0

High-throughput

0.249

Low

577447

F1711
Protein FAM171A1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025