HitPredict

Interactor 1: PRLR (P16471)
Prolactin receptor (PRL-R)
Gene: PRLR

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10991949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 622 Hs			1 593
+	Mm
		562609 GHR_MOUSE (29-486): 5.85e-65: 227: 25.95		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		500960 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		985991 I22R1_HUMAN (9-538): 1.45e-63: 221: 15.72		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		872429 EPHA5_HUMAN (27-330): 3.07e-57: 210: 13.10		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		985961 EPHA7_HUMAN (27-330): 1.29e-56: 208: 15.12		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986020 CSF3R_HUMAN (14-240): 2.73e-53: 197: 22.08		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		872635 EPHA4_HUMAN (27-330): 7.92e-52: 194: 12.38		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		701713 IL3RB_HUMAN (29-573): 3.81e-51: 191: 15.63		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		540446 IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665805 IL3RB_HUMAN (29-573): 3.81e-51: 191: 15.63		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		500946 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Hs
		500961 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55
+	Hs
		265768 CRLF1_HUMAN (15-234): 1.56e-52: 187: 33.48		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		616944 EPHA8_HUMAN (27-354): 5.47e-49: 185: 15.21		PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76
+	Hs
		500943 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573629 EPHA5_HUMAN (27-330): 3.07e-57: 210: 13.10		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573583 EPHA8_HUMAN (27-354): 5.47e-49: 185: 15.21		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		441167 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		500966 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94
+	Hs
		500942 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00