Protein: VPS45
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)

Gene: VPS45
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q9NRW7

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005794 - Golgi apparatus
GO:0006886 - intracellular protein transport
GO:0008021 - synaptic vesicle
GO:0010008 - endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

160920

STX16
Syntaxin-16

6

20

High-throughput

0.948

High

226221

STX6
Syntaxin-6

4

12

High-throughput

0.895

High

278566

VAMP4
Vesicle-associated membrane protein 4

2

12

High-throughput

0.811

High

249900

STX10
Syntaxin-10

2

13

High-throughput

0.789

High

1154761

VAMP3
Vesicle-associated membrane protein 3

2

15

High-throughput

0.789

High

189869

STX7
Syntaxin-7

2

20

High-throughput

0.754

High

1294843

STX12
Syntaxin-12

2

20

High-throughput

0.737

High

328746

VAMP5
Vesicle-associated membrane protein 5

2

14

High-throughput

0.726

High

1431138

RBNS5
Rabenosyn-5

5

6

Small-scale

0.726

High

1448943

STX8
Syntaxin-8

1

17

High-throughput

0.691

High

631502

RAB5A
Ras-related protein Rab-5A

4

11

Small-scale

0.676

High

933062

SNAA
Alpha-soluble NSF attachment protein

3

9

High-throughput

0.675

High

1383309

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

3

10

High-throughput

0.667

High

1448938

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

10

High-throughput

0.667

High

1242242

NPAL3
NIPA-like protein 3

3

2

High-throughput

0.650

High

1242950

S39A4
Zinc transporter ZIP4

4

6

High-throughput

0.619

High

1087310

STX4
Syntaxin-4

1

20

High-throughput

0.618

High

243051

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

375992

RASK
GTPase KRas

2

16

High-throughput

0.584

High

540699

LAMP1
Lysosome-associated membrane glycoprotein 1

2

8

High-throughput

0.584

High

901601

RAB7A
Ras-related protein Rab-7a

2

13

High-throughput

0.584

High

976591

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.584

High

978335

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

397028

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

1086122

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

1

High-throughput

0.549

High

294894

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

3

High-throughput

0.541

High

465665

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.541

High

343484

SNP29
Synaptosomal-associated protein 29

1

14

High-throughput

0.536

High

1387131

HVCN1
Voltage-gated hydrogen channel 1

1

2

High-throughput

0.536

High

1407046

SNAG
Gamma-soluble NSF attachment protein

1

9

High-throughput

0.536

High

1431438

EHD4
EH domain-containing protein 4

1

1

High-throughput

0.536

High

390780

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.515

High

611376

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.494

High

1040084

PAX2
Paired box protein Pax-2

1

1

High-throughput

0.494

High

1132446

CASP8
Caspase-8

1

1

High-throughput

0.494

High

1351988

RBCC1
RB1-inducible coiled-coil protein 1

1

4

High-throughput

0.494

High

1448939

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

3

High-throughput

0.494

High

1406997

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

791760

SYUA
Alpha-synuclein

1

3

High-throughput

0.481

High

126822

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

140002

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.479

High

180064

BET1
BET1 homolog

1

11

High-throughput

0.479

High

218824

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

327468

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

363909

EGFR
Epidermal growth factor receptor

1

14

High-throughput

0.479

High

374224

RASN
GTPase NRas

1

16

High-throughput

0.479

High

374958

RASH
GTPase HRas

1

13

High-throughput

0.479

High

412669

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

464065

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

16

High-throughput

0.479

High

508693

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

541705

FGFR1
Fibroblast growth factor receptor 1

1

18

High-throughput

0.479

High

560535

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

562429

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.479

High

604231

CXA1
Gap junction alpha-1 protein

1

9

High-throughput

0.479

High

630646

RAB3B
Ras-related protein Rab-3B

1

6

High-throughput

0.479

High

630991

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.479

High

648695

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

783428

TRI23
E3 ubiquitin-protein ligase TRIM23

1

4

High-throughput

0.479

High

901065

RAB5C
Ras-related protein Rab-5C

1

11

High-throughput

0.479

High

902099

RAB9A
Ras-related protein Rab-9A

1

13

High-throughput

0.479

High

955651

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956512

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.479

High

958034

RAB14
Ras-related protein Rab-14

1

10

High-throughput

0.479

High

975270

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

988747

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

989133

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

1041317

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1145127

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.479

High

1256607

CE128
Centrosomal protein of 128 kDa

1

6

High-throughput

0.479

High

1276330

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1334584

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1368960

GOGA1
Golgin subfamily A member 1

1

1

High-throughput

0.479

High

1370397

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1436330

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1448936

ANFY1
Rabankyrin-5

1

1

High-throughput

0.479

High

1448937

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

1312612

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1358026

TM171
Transmembrane protein 171

1

0

High-throughput

0.458

High

1420641

SPEF2
Sperm flagellar protein 2

1

0

High-throughput

0.458

High

1448358

PICK1
PRKCA-binding protein

1

0

High-throughput

0.458

High

1448934

SNTG1
Gamma-1-syntrophin

1

6

Small-scale

0.457

High

722635

CTR1
High affinity cationic amino acid transporter 1

1

9

High-throughput

0.445

High

1034070

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

2

High-throughput

0.445

High

1093590

TRDN
Triadin

1

3

High-throughput

0.445

High

1131626

MFS10
Major facilitator superfamily domain-containing protein 10

1

4

High-throughput

0.445

High

1209701

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1292144

ANR46
Ankyrin repeat domain-containing protein 46

1

4

High-throughput

0.445

High

1363459

S39A7
Zinc transporter SLC39A7

1

6

High-throughput

0.445

High

1412211

S35A5
UDP-sugar transporter protein SLC35A5

1

3

High-throughput

0.445

High

1417155

S12A9
Solute carrier family 12 member 9

1

10

High-throughput

0.445

High

106708

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

294389

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

324220

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.437

High

341154

DIRA3
GTP-binding protein Di-Ras3

1

6

High-throughput

0.437

High

386494

SPTA1
Spectrin alpha chain, erythrocytic 1

1

4

High-throughput

0.437

High

390342

CXCL7
Platelet basic protein

1

1

High-throughput

0.437

High

466483

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.437

High

581314

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.437

High

589802

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

696618

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

769284

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

848303

MAGA3
Melanoma-associated antigen 3

1

1

Small-scale

0.437

High

910216

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.437

High

953697

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.437

High

962535

RHOA
Transforming protein RhoA

1

20

High-throughput

0.437

High

1015829

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.437

High

1031558

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

1151897

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.437

High

1227530

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.437

High

1233514

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1235339

STYK1
Tyrosine-protein kinase STYK1

1

12

High-throughput

0.437

High

1255711

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1276839

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1291586

HOOK3
Protein Hook homolog 3

1

5

High-throughput

0.437

High

1293171

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1323011

CXD3
Gap junction delta-3 protein

1

9

High-throughput

0.437

High

1367375

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

1431762

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.437

High

1433528

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.437

High

1435341

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.437

High

1438176

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.437

High

1448935

GPC5D
G-protein coupled receptor family C group 5 member D

1

8

High-throughput

0.437

High

1448940

HOOK1
Protein Hook homolog 1

1

6

High-throughput

0.437

High

1448942

HPCL4
Hippocalcin-like protein 4

1

1

High-throughput

0.437

High

1448944

LAMP3
Lysosome-associated membrane glycoprotein 3

1

8

High-throughput

0.437

High

1448945

NINL
Ninein-like protein

1

5

High-throughput

0.437

High

851227

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.426

High

1439125

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

530432

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.407

High

653596

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

912719

CTR2
Cationic amino acid transporter 2

1

9

High-throughput

0.407

High

1308539

SL9A9
Sodium/hydrogen exchanger 9

1

1

High-throughput

0.407

High

1348644

S7A14
Solute carrier family 7 member 14

1

9

High-throughput

0.407

High

1355936

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.407

High

1361319

CTR3
Cationic amino acid transporter 3

1

9

High-throughput

0.407

High

1389605

SAAL1
Protein SAAL1

1

3

High-throughput

0.407

High

1404960

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.407

High

1421357

S39A8
Metal cation symporter ZIP8

1

6

High-throughput

0.407

High

1293301

LSR
Lipolysis-stimulated lipoprotein receptor

2

0

High-throughput

0.328

High

269394

HSF2B
Heat shock factor 2-binding protein

1

0

High-throughput

0.279

Low

871800

RFX3
Transcription factor RFX3

1

0

High-throughput

0.279

Low

993909

TYB10
Thymosin beta-10

1

0

High-throughput

0.279

Low

1446707

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

715801

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

1141964

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

1213441

AT7L2
Ataxin-7-like protein 2

1

0

High-throughput

0.249

Low

1337421

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.249

Low

1448941

ZN225
Zinc finger protein 225

1

0

High-throughput

0.249

Low

1310451

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025