HitPredict

Interactor 1: BIP (P16474)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein homolog) (GRP-78) (Immunoglobulin heavy chain-binding protein homolog) (BiP)
Gene: KAR2

Interactor 2: LHS1 (P36016)
Heat shock protein 70 homolog LHS1 (EC 3.6.1.-)
Gene: LHS1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 14704430, 20177057, 19759005, 32051233, 20430899, 22875988
Identification Methods affinity chromatography technology, cross-linking study, pull down, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HSP70~HSP70
Common GO terms GO:0005524 - ATP binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006986 - response to unfolded protein
GO:0016887 - ATP hydrolysis activity
and 5 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 682
Sc

1 881
+ Hs
+ Hs
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+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Dm
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024