Protein: RIO2
Serine/threonine-protein kinase RIO2 (EC 2.7.11.1)

Gene: RIO2
Organism: Saccharomyces cerevisiae S288C
Interactions: 145
UniProt ID: P40160

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

820401

TSR1
Ribosome biogenesis protein TSR1

15

4

Small-scale

0.981

High

688901

RS5
Small ribosomal subunit protein uS7

9

3

Small-scale

0.962

High

674657

RS2
Small ribosomal subunit protein uS5

5

4

Small-scale

0.906

High

514149

RS16B
Small ribosomal subunit protein uS9B

3

5

Small-scale

0.827

High

820412

RS25A
Small ribosomal subunit protein eS25A

3

4

Small-scale

0.827

High

798230

ENP1
Essential nuclear protein 1

16

4

Small-scale

0.761

High

820403

NOB1
20S-pre-rRNA D-site endonuclease NOB1

14

4

Small-scale

0.758

High

820371

DIM1
Dimethyladenosine transferase

13

2

Small-scale

0.757

High

820415

PNO1
Pre-rRNA-processing protein PNO1

13

3

Small-scale

0.757

High

511669

RS23B
Small ribosomal subunit protein uS12B

2

2

Small-scale

0.754

High

820408

RIO1
Serine/threonine-protein kinase RIO1

2

3

High-throughput

0.754

High

709392

HRR25
Casein kinase I homolog HRR25

8

1

Small-scale

0.749

High

435128

RS3
Small ribosomal subunit protein uS3

10

3

Small-scale

0.748

High

513038

RS8A
Small ribosomal subunit protein eS8A

8

4

Small-scale

0.741

High

441939

RS14A
Small ribosomal subunit protein uS11A

7

4

Small-scale

0.736

High

820388

RS15
Small ribosomal subunit protein uS19

7

3

Small-scale

0.736

High

756682

LTV1
Protein LTV1

15

0

Small-scale

0.727

High

149795

RS9A
Small ribosomal subunit protein uS4A

6

4

Small-scale

0.726

High

383728

RS17A
Small ribosomal subunit protein eS17A

6

4

Small-scale

0.726

High

435996

RS13
Small ribosomal subunit protein uS15

6

3

Small-scale

0.726

High

747400

RSSA1
Small ribosomal subunit protein uS2A

6

7

Small-scale

0.726

High

512087

RS4A
Small ribosomal subunit protein eS4A

6

3

Small-scale

0.719

High

753400

RS3A1
Small ribosomal subunit protein eS1A

6

6

Small-scale

0.719

High

502735

RS21A
Small ribosomal subunit protein eS21A

5

5

Small-scale

0.709

High

455095

RS19A
Small ribosomal subunit protein eS19A

5

5

Small-scale

0.702

High

512471

RS6A
Small ribosomal subunit protein eS6A

5

4

Small-scale

0.702

High

514665

RS18A
Small ribosomal subunit protein uS13A

5

3

Small-scale

0.702

High

689487

RS7A
Small ribosomal subunit protein eS7A

5

5

Small-scale

0.702

High

802204

RS20
Small ribosomal subunit protein uS10

5

3

Small-scale

0.702

High

820377

RS12
Small ribosomal subunit protein eS12

5

2

Small-scale

0.702

High

820410

RRP12
Ribosomal RNA-processing protein 12

4

2

Small-scale

0.691

High

503074

RS22A
Small ribosomal subunit protein uS8A

4

4

Small-scale

0.676

High

513872

RS11B
Small ribosomal subunit protein uS17B

4

4

Small-scale

0.676

High

792077

GBLP
Small ribosomal subunit protein RACK1

4

6

Small-scale

0.676

High

655467

RS3A2
Small ribosomal subunit protein eS1B

4

6

Small-scale

0.674

High

815812

BEM2
GTPase-activating protein BEM2/IPL2

3

4

High-throughput

0.671

High

503500

RS28B
Small ribosomal subunit protein eS28B

3

5

Small-scale

0.656

High

811989

RS14B
Small ribosomal subunit protein uS11B

3

4

Small-scale

0.646

High

435578

RS9B
Small ribosomal subunit protein uS4B

3

4

Small-scale

0.640

High

455413

RS19B
Small ribosomal subunit protein eS19B

3

5

Small-scale

0.640

High

677421

KRR1
KRR1 small subunit processome component

3

2

Small-scale

0.640

High

778359

RS27A
Small ribosomal subunit protein eS27A

3

3

Small-scale

0.640

High

815404

RS26B
Small ribosomal subunit protein eS26B

3

3

Small-scale

0.640

High

820369

RS29A
Small ribosomal subunit protein uS14A

3

3

Small-scale

0.640

High

820373

RSSA2
Small ribosomal subunit protein uS2B

3

7

Small-scale

0.640

High

820375

RS7B
Small ribosomal subunit protein eS7B

3

5

Small-scale

0.640

High

820404

RS10A
Small ribosomal subunit protein eS10A

3

5

Small-scale

0.640

High

820411

RS21B
Small ribosomal subunit protein eS21B

3

5

Small-scale

0.640

High

820413

RS28A
Small ribosomal subunit protein eS28A

3

5

Small-scale

0.640

High

643642

SNF2
Transcription regulatory protein SNF2

2

6

High-throughput

0.621

High

721984

XPO1
Exportin-1

2

8

Small-scale

0.619

High

502652

RS25B
Small ribosomal subunit protein eS25B

1

4

Small-scale

0.618

High

820367

RIO2
Serine/threonine-protein kinase RIO2

1

3

Small-scale

0.618

High

820380

SLX9
Ribosome biogenesis protein SLX9

3

0

Small-scale

0.613

High

820414

RS22B
Small ribosomal subunit protein uS8B

2

4

Small-scale

0.611

High

820379

EIF2A
Eukaryotic translation initiation factor 2A

3

2

High-throughput

0.604

High

614827

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

2

3

High-throughput

0.588

High

743030

SWI3
SWI/SNF complex subunit SWI3

2

3

High-throughput

0.588

High

436433

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

4

Small-scale

0.584

High

511805

RS24A
Small ribosomal subunit protein eS24A

2

3

Small-scale

0.584

High

570262

RS17B
Small ribosomal subunit protein eS17B

2

4

Small-scale

0.584

High

815360

RS26A
Small ribosomal subunit protein eS26A

2

3

Small-scale

0.584

High

820370

RS29B
Small ribosomal subunit protein uS14B

2

3

Small-scale

0.584

High

444535

DED1
ATP-dependent RNA helicase DED1

1

7

Small-scale

0.536

High

569795

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

585950

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.536

High

622961

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.536

High

807764

CSK2C
Casein kinase II subunit beta'

1

4

High-throughput

0.536

High

810647

SSN3
Meiotic mRNA stability protein kinase SSN3

1

6

High-throughput

0.536

High

820368

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

4

High-throughput

0.536

High

820372

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.536

High

820376

ASK10
Activator of SKN7 protein 10

1

4

High-throughput

0.536

High

820383

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.536

High

820398

BFR2
Protein BFR2

1

1

High-throughput

0.536

High

820409

DBP10
ATP-dependent RNA helicase DBP10

1

12

High-throughput

0.536

High

805596

LSM12
Protein LSM12

1

0

High-throughput

0.513

High

820381

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.513

High

602485

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

656488

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.501

High

745759

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

Small-scale

0.501

High

820399

TSR2
Pre-rRNA-processing protein TSR2

1

0

High-throughput

0.493

High

410165

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

427304

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.479

High

433673

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

464605

PBS2
MAP kinase kinase PBS2

1

3

High-throughput

0.479

High

511935

RS30A
Small ribosomal subunit protein eS30A

1

1

Small-scale

0.479

High

531762

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

560710

KIN2
Serine/threonine-protein kinase KIN2

1

3

High-throughput

0.479

High

570038

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

571353

CPYI
Carboxypeptidase Y inhibitor

1

2

Small-scale

0.479

High

632801

DBP5
ATP-dependent RNA helicase DBP5

1

9

Small-scale

0.479

High

666476

DBP2
ATP-dependent RNA helicase DBP2

1

6

High-throughput

0.479

High

707239

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

727069

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

737875

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.479

High

743393

TOR2
Serine/threonine-protein kinase TOR2

1

6

High-throughput

0.479

High

757883

UBX1
UBX domain-containing protein 1

1

1

Small-scale

0.479

High

758217

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

High-throughput

0.479

High

802727

RS27B
Small ribosomal subunit protein eS27B

1

3

Small-scale

0.479

High

803262

OTU2
OTU domain-containing protein 2

1

1

High-throughput

0.479

High

809324

STM1
Suppressor protein STM1

1

1

High-throughput

0.479

High

812348

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

815134

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

820374

RS10B
Small ribosomal subunit protein eS10B

1

5

High-throughput

0.479

High

820384

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

820385

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

4

High-throughput

0.479

High

820387

NOP3
Serine/arginine

1

9

High-throughput

0.479

High

820390

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

820393

RGC1
Regulator of the glycerol channel 1

1

4

High-throughput

0.479

High

820400

YL419
Putative ATP-dependent RNA helicase YLR419W

1

6

High-throughput

0.479

High

820406

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

5

High-throughput

0.479

High

820407

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

820416

MEX67
mRNA export factor MEX67

1

1

Small-scale

0.479

High

482028

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

672896

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

758033

MTR2
mRNA transport regulator MTR2

1

0

Small-scale

0.458

High

795377

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

818232

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.458

High

820378

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.458

High

820382

PXR1
Protein PXR1

1

0

High-throughput

0.458

High

820392

AVO2
Target of rapamycin complex 2 subunit AVO2

1

0

High-throughput

0.458

High

820394

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

820395

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

High-throughput

0.458

High

820396

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

820397

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

820402

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.458

High

796155

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.457

High

409737

RL24A
Large ribosomal subunit protein eL24A

1

2

Small-scale

0.445

High

453627

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.445

High

545066

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

554002

TCPA
T-complex protein 1 subunit alpha

1

5

High-throughput

0.445

High

752318

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

796583

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

Small-scale

0.445

High

807191

IF1A
Eukaryotic translation initiation factor 1A

1

2

Small-scale

0.445

High

818886

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

820389

HAS1
ATP-dependent RNA helicase HAS1

1

13

High-throughput

0.445

High

456533

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

1

High-throughput

0.437

High

789827

YC16
UPF0743 protein YCR087C-A

1

2

High-throughput

0.437

High

820386

NUM1
Nuclear migration protein NUM1

1

6

High-throughput

0.437

High

820405

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

803227

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.279

Low

642144

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

820391

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

748179

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025